531
30223226014562121
Ces8507936014570127174
Urol10497936014578115180208
2018;12827936014562121176230253
22(1):15617936014561121152206230252
27–3118397936014561118172231284
PŘEHLEDOVÝ852207016974156235334409485586692777867
ČLÁNEK1757207016989163260360438521
na850898013159109
vzniku985898013159107168191238297
a1308898013159
závažnosti1393898013153106155207253313373414451474
LUTS‑BHP1893898013158125178231266324395450
se2369898013150105
významně2500898013159112161221271362421476
podílí8501048013161122184207233256
tkáňová1132104801313683135195254304356
hypoxie15151048013159107169230277301356
a18961048013152
dysbalance19751048013160110152213265289339398449501
androgen‑25021048013151111172205263325380439474
ního850119801316185149212
prostředí.10891198013172108168211249284339404428449
S15661198013162
těmito16551198013146100194219255315
etiopatogenetickými19971198013165102127189253306342402466523585642678703755804859954979
faktory850134801312981128167224258311
se11871348013146100
setkáváme13131348013145100135182235284335426481
častěji18191348013154105146183235258282
s21261348013146
rostoucím2198134801313695136172230290340363454
věkem26781348013154107154207298
a8501498013150
u9231498013159
pacientů10051498013161112162185239298332390
s14211498013139
přítomným1483149801316194118153210301360408499
METS.20061498013185137192244265
Z22941498013159
toho2379149801313289149209
vyplývá,26111498013150103165190239294345365
že850164801314497
i9731648013128
léčba1027164801312882133194246
LUTS‑BHP12991648013154120174227262320390446
by17711648013165114
měla19161648013190145169219
z21611648013149
těchto2236164801313991142201235292
poznatků25541648013166127171231281315362422
vycházet.8501798013149102150208257302354388408
Je1283179801313589
nezbytné13951798013158111156217265303362416
se1835179801313992
oprostit19501798013158118151208249284307341
od23141798013157118
historických2455179801315880120155212245268317363415463521
dogmat8501948013161123187281333369
o12461948013170
negativním13431948013171127192244279304357420444538
působení19081948013172134176238303360422446
testosteronu23811948013146100144182241285322377411472534595
na8502098013161113
prostatickou9902098013173108168212250303338363415464525587
tkáň1604209801314594149210
se18412098013153110
zhoršením19782098013155118180215259316378403496
LUTS‑BHP,25012098013161130186240277337410468475
natož8502248013160112147206252
rizika1129224801314368115140188242
vzniku13982248013161110172197245306
CaP17312248013174127184
(4).1942224801314093120138
Naopak21072248013181133195258312360
je2494224801313490
vhodné26102248013161123185248310366
u3203898013158
symptomatických328789801314091183244279336428478512536586633686735794
hypogonadických4106898013159107169230292352412463524547597644697746806
pacientů4937898013160112162186240299333392
léčených3203104801312378129181241288337397
pro3629104801316195153
středně3808104801314581114167229288343
závažné41771048013148100150201247307362
LUTS‑BHP45651048013153120173226261319389445
zahájit50361048013148101160211235258293
TRT.32031198013152111165180
U34091198013180
těchto3515119801314598150211245304
pacientů38451198013172125176200255316350411
nedochází42821198013170126189250302363414462487
ke47951198013157112
zhoršení49331198013155116177212255311372396
symptomů3203134801314191182243277334425483
LUTS,37091348013149115168220240
ale3972134801314973127
také4124134801313283129182
je4332134801312175
možné44301348013189149193252307
jejich476213480131217598121171230
zlepše‑5017134801314266120181222276312
ní.3203149801315881100
Zároveň33261498013159109141199248300358
lze3710149801312065117
očekávat38491498013158108160206258306356389
pozitivní42611498013160120163187221244294353376
přínos4660149801316093116174233274
na49571498013158108
METS50871498013185136190242
(11,3203164801312978121134
12,33621648013154100119
13,35071648013154100118
14).36511648013153102128145
Z38211648013160
tohoto3906164801313492152212246304
pohledu42351648013161122182206260322381
lze4641164801312369122
konstatovat,47891648013146104164205242293327384434486520540
že3203179801314598
TRT33271798013161119172
patří35251798013171123157190215
do37661798013169129
komplexní39211798013157116207269294349398459482
péče44291798013171127178230
o46851798013169
stárnoucího4780179801315187139172233293353403427489549
muže,32031948013190149195247266
a34951948013150
společně35701948013141102163188242293353407
s40031948013141
úpravou40701948013158119153204254312372
dalších44681948013160110134174197247306
etiopatoge‑4800194801315388112171233285318376438493529
netických32032098013159114148172222269322371431
faktorů3659209801313688135174231265325
METS40162098013185138193245
vede42872098013156110172226
ke45392098013153106
zvýšení46712098013151105159201256315338
kvality50352098013153108159183206241294
života3203224801314468119178212263
a34922248013152
prodloužení3571224801316194153214238298358403456516539
jeho4136224801312579139199
délky.43622248013160115139185239254
LITERATURA852268401475992157220291371428510580661
1.850284601335673
Dohle9482846013374134195221276
GR,12492846013371130155
Arver14292846013367102158212247
S,1701284601335477
Bettocchi18032846013359115151190249298346406431
C,2259284601336388
et2372284601335591
al.2488284601335378101
Guidelines26152848013169127148208260283305362415455
on30962848013159117
male32392848013190139161214
hypogonadism.34782848013159105166226286344402451511533572660679
Dostupný41832848013171130170204262322380426
z46332848013146
http://uroweb.4705284801315991127187204245275329360417495547607625
org/wp‑content/uploads/EAU‑Guidelines‑Male‑Hypogonadism-2015.pdf.850299801315991148188266326362413469527559610668700741796855878936986104610851124117512401305133814101468149015491602162416461703175617971828191419631985203820732143219122522311237224302488253725962618265727462779282628772925297029863047310831363152
2.850314601335780
Wang9613146013393144205266
C,1258314601336489
Nieschlag1378314601337398153197246307332385446
E,1848314601336285
Swerdloff19563146013362141196231293319379411443
R,2423314601336792
et2539314601336399
al.2662314601336186109
Investigation,2795314801313290137189230264287346395427450508567585
treatment3404314801314274126174207297350408440
and38693148013158116176
monitoring40773148013190149208230263320352375433492
of4594314801316695
late‑onset4713314801313281113164199260319358412445
hy‑51823148013168114147
pogonadism8503298013161120180238297346405427466554
in1428329801312885
males:15413298013190139161214254272
ISA,1837329801312776138159
ISSAM,2020329801312776125187272292
EAU,23363298013155120185200
EAA25603298013155121187
and27713298013154111171
ASA29703298013164116178
recommendations.3172329801313789138194284373426484543592624646704762802821
Eur.40173298013155111142156
J.4197329801314260
Endocrinol.42813298013155113172230280311334391449473491
2008;47963298013158109164218235
159(5):50553298013158103151180230257274
507–514,8503448013154105154203254301347364
Int1238344801312078110
J13723448013135
Impot14313448013120109168227260
Res.17123448013155108148168
2009;19013448013153105160213232
21(1):21533448013154101123170190207
1–8,23813448013154103158176
Int2581344801312178110
J27153448013135
Androl.27713448013164122182213269292311
2009;31033448013153105160213232
32(1):33553448013154103128176196213
1–10,35883448013154103150197214
Int3826344801312078110
J39603448013134
Androl.40153448013165123182213270293311
2009;43473448013154105160214232
32(1):46003448013154103128175195212
1–10,48333448013154103149196214
Aging50673448013165123145202262
Male.8503598013186135157210227
2008:11013598013154105160214232
1–8.13573598013153103158177
3.850374601335678
Rosen9503746013359119162217278
RC,12493746013360123147
Giuliano1418374601337197156182207259319379
F,1819374601335466
Carson19063746013364117152196257318
CC.22453746013364124149
Sexual24163748013151104152210258281
dysfunction27193748013160108149178237295343380402459518
and32593748013150108168
lower3451374801312179157210241
urinary3714374801315990113170219250302
tract4040374801313264114163199
symptoms4263374801313989179238271327417456
(LUTS)4743374801312876140192243271
associ‑5037374801315089129187237259292
ated850389801315082133193
with10673898013180102136194
benign12853898013161115173194253311
prostatic1620389801316193149189224274306328376
hyperplasia20203898013159105166220251312335384423445493
(BPH).2537389801312984138205233248
Eur28093898013151106138
Urol.2971389801316999156179197
2005;31933898013153105160211226
47(6):34433898013154102126176202219
824–837.36863898013154104152209264315364371
4.850404601335679
Khera9524046013359122177212265
M,12404046013389113
Crawford1376404601336498151231266326362423
D,1822404601337393
Morales19384046013388149185238263318361
A,2322404601336892
et2438404601335591
al.2552404601335379101
Testosterone2677404801315197137172228268302353385441500553
and32544048013150108167
prostate3445404801316193149189224273306356
cancer3825404801315099157206257288
–41374048013155
a42164048013150
paradigm42904048013160110142192251273332421
shift4735404801314198120148186
„Bye‑bye4945404801313288137189224285332384
Androgen8504198013164122182213270330383441
Hypothesis,13154198013170118178238270328381421443482500
Welcome18404198013190140163211267357410
Saturation22744198013151101133191222272304326384443
Model“.27414198013186144205257280312325
Eur30904198013151107138
Urol.32524198013169100157180198
2014;34754198013153105153199216
65(1):37154198013154105131178198215
115–123,3955419801315394139194240285337354
dostupné43344198013160118158192250309368421
také4779419801313584130181
z49844198013145
http://5054419801315990127187204245274
www.europeanurology.com/article/S0302–2838(13)00843–9/pdf.85043480131791622442593113694004565175716196777347658218449029631011102510731129121912581303133413721394144214641517155616061659170917611811186219101961201220642092214021842209226223172371242724762531258426182675273527642780
5.850449601335677
Alonso‑Magdalena954449601336792152213256316352442495556618671696751812864
P,1844449601335968
Brössner1939449601335995155197240300355391
C,2356449601336488
Reiner24704496013359115140200255291
A,2787449601336892
et2906449601335591
al.3023449601335379101
A31524498013164
role3240449801313692116168
for3432449801313290122
epithelial‑mesenchymal3578449801315611613817223028330532737539743052157461466772577483187796810171039
transition4641449801313769119176216237270292350409
in5074449801312683
the5182449801313795148
etiology850464801315386109166189247308356
of1230464801315987
benign13414648013161115173195254311
prostatic1676464801316193150190224274306328376
hyperplasia.20764648013159105166220252312335384424445493512
Proc2613464801315585142191
Natl28284648013171119152174
Acad30264648013164112162221
Sci32714648013151100122
USA.34174648013169117179200
2009;36414648013154106161214232
106(8):38974648013154101156183234261277
2859–2863.41984648013154105157205262310361414465483
6.850479601335678
Bravo948479601335994146197255
G,1222479601337194
Massa13354796013388141183225278
H,1632479601337194
Rose‘Meyer17454796013359118161215237324379430483518
R,2282479601335984
et2385479601335590
al.249547960133527799
Effect2615479801315178108159208244
of2879479801315886
shortterm2985479801314197155187223259310341430
androgen34354798013149106165196252312364421
deficiency38764798013159112137164211233285342390441
on43364798013159116
bladder4472479801316183131190249301332
contractility48244798013149104162194225274322358380401422455506
and8504948013150107166
urothelial1036494801315888144176234286308330377399
mediator14554948013190142202223271303358390
release.1868494801312980102154202241294310
Naunyn21984948013170118175232277336
Schmiedebergs2554494801315199156244265317377429488542573630669
Arch3243494801316495141198
Pharmacol.34614948013155111159190279327376431454472
2017;39524948013154105152195208
11.4180494801315494106
Dostupné43064948013170129168202259318376429
také4759494801312979124175
z49534948013145
https://5017494801315990126186225243283312
www.ncbi.nlm.nih.gov/pubmed/28190243.850509801317916224425931836642644846752654863765571573679481387293097810121069112811871277133013901430148315331581162616811730177818271845
7.850524601335666
Hammarsten9355246013370122211300351385428464516575
J,1529524601334060
Peeker16085246013357109163213265300
R.1926524601335882
Urological2028524801316898153175231290311358406428
aspects2475524801314987145198246281321
of2815524801315885
the2923524801313086138
metabolic30805248013189140172221279337359379426
syndrome.3525524801314189146204234289377429445
Nat39895248013169117148
Rev41565248013155106154
Urol.4329524801316897152175192
2011;45405248013153103150189200
8(9):4759524801315279127152168
483–494.49465248013153106156210265314367384
Dostupný8505398013171130170205262322380426
také1300539801313484130181
z15055398013145
http://www.medscape.com/viewarticle/750517_print.1574539801315990127187204245274353435517532622675736775824873933987100410521108119812371286130913611440148915211558158016281650170317421797184618971949199520392084214721792202225922912310
8.850554601335680
Wang9595546013393144204265
CH,12545546013364134157
Jackson14345546013347100149199245306367
G,1830554601337195
Jones19495546013347107168223266
TH,22385546013361133156
et2418554601336198
al.2539554601335985107
Low26705548013156113191
testosterone2885554801314192132166222262297348379436494547
associated3456554801315797136195244266314346397458
with39445548013180102136194
obesity41625548013165125179219241274325
and45115548013157115174
the4709554801314199152
metabolic48915548013190144177226286345368390438
syndrome850569801314190149209240297386439
contributes13125698013149105164196227250309367401452492
to1828569801313389
sexual1941569801314093141198247269
dysfunction22335698013160108149178237295344380402459518
and27745698013150107167
cardiovascular2964569801314998130188209267315365405454511533582613
disease3600569801316082121174222261314
risk393956980131315392137
in4100569801312280
men42025698013190144202
with44265698013180102136194
type4644569801313284145199
248655698013154
diabetes.4942569801316081130189243277327368387
Diabetes850584801317194142202256289340380
Care,12545848013163112144195212
2011;14905848013154105153194204
34:17185848013154108125
1669–1675.18675848013154100154206263309356405455471
9.850599601335675
Andersson9525996013367127189244280324366427487
KE,14655996013360115138
de16295996013362117
Groat17725996013371107167220255
WC,20535996013393155179
McVary22595996013388137198248283338
KT,26235996013360118134
et2783599601335592
al.2901599601335378101
Tadalafil3026599801315496155204226275300327349
for3399599801313289121
the3544599801313795148
treatment3716599801313768120168200290343401432
of4175599801315987
lower4286599801312785163215246
urinary4559599801315990113170219250302
tract4885599801313769119167203
sym‑5113599801314393183216
ptoms850614801316092147236275
secondary1144614801314193142197255313361392443
to1610614801313085
benign17156148013160113170192250307
prostatic2041614801316092147187221269301323370
hyperplasia:24316148013158103163217247307330377416437485501
pathophysiology29526148013160109141198255315373418458479535558615675722
and36946148013149106165
mechanism(s)38786148013190142191248296353374412499527564588
of4486614801315886
action.4591614801315098133155212269287
Neurourol48986148013170122178209265322353408431
Urodyn.8506298013169100156217265324343
2011;12176298013154105153194204
30:14456298013154106125
292–301.15946298013154105155207256308356368
10.8506446013356107129
Schmidt10026446013359108168259284346382
LJ,14086446013356100121
Duncan15576446013373134194243296357
K,1942644601335985
Yadav20556446013359106168220271
N,2354644601337295
et2473644601335996
al.2592644601335783105
RhoA27226448013160119177239
as2985644801315595
a31046448013154
mediator31876448013190143204226274306362394
of3610644801315887
clinically372164480131547697155176225274297318366
relevant4111644801313789112164213263321353
androgen44886448013154112171203259320372430
action49426448013155104140162220278
in5244644801312886
prostate850659801316194152192228278311363
cancer12376598013158109168217269301
cells.15636598013157109132155194214
Mol18106598013187146170
Endocrinol.20046598013160119179238289321344402462485504
2012;25336598013162115163209227
26(5):27856598013163114143194222239
716–735.30496598013162112159218266319370387
Dostupné34696598013172132172208266327386440
z39346598013153
http://www.ncbi.nlm.nih.gov/4012659801316810013719821625728836745153454960965971974276182184493495310131036109411141174123312821317
pubmed/22456196.8506748013161119178268321382421474527574624676721766820839
11.8506896013356101118
Kathrins9946896013359113148209244269329372
M,13916896013389113
Doersch15296896013374134190226270319379
K,1933689601336086
Nimeh2044689601337398189244305
T,2374689601335571
et2470689601335692
al.2587689601335379101
The27136898013154113167
relationship2904689801313486108157189211269328367424446506
between34366898013161115148229282335393
testosterone3853689801313788128162218258293344375432490543
replacement4420689801313587146169218267318407460518550
therapy4994689801313694147178228288335
and8507048013149106164
lower1038704801311976153204234
urinary1292704801315788110166214245295
tract1611704801312960109157192
symptoms:1823704801314089177236268323411449466
a23097048013149
systematic2378704801314088128162212299347379400447
review.2849704801312878126148200277291
Urology3160704801316898153176233292339
2016;35197048013153103150196213
88:37527048013153105122
22–32,38937048013154105156204252269
(ISSN418570480131254693141208
1527–9995),4412704801315397146195242294346399450476491
dostupný49227048013159116155189246304362407
také850719801313484129181
z10557198013144
http://reference.medscape.com/medline/abstract/26616095?prt=true1123719801315991127187205245275304355383435467518576625676693783836896936984103410941148116512131269135913981484153715981620164116991752179118371896193619712003205221012137217922322283233723822429248225362587262726852717275428152848287929382991
12.8507346013356104127
Crawford999734601336499152231266326362423
ED,14447346013355127146
Poage16127346013358116170231286
W,19207346013393110
Nyhuis20537346013372124185245270312
A,2387734601336892
Price2501734601335993119168221
DA,27447346013373137162
Dowsett29287346013373134214257312348387
SA,33377346013354120144
Muram35037346013389149184237328
D.3853734601337493
Effects3969734801315179109161210247288
of4280734801315987
Testosterone4390734801315197137172228268302353384441500553
Level49657348013150101150202225
on52127348013159117
Lower8507498013149106184236268
Urinary11387498013169100123180229260312
Tract1471749801315175125174210
Symptoms.1702749801315195186245278334424463483
Am22057498013164154
J23837498013134
Mens24387498013185139196236
Health.26947498013170123171193226284303
2016;30187498013153105153199218
10(5):32567498013154101130180207224
440–442.35017498013153110164222279335384402
Dostupný39237498013171130170205263322381427
také4374749801313080125177
z45727498013144
http://reference.4636749801315991128188205246275304355383436467518576625676693
medscape.com/medline/abstract/26077271?prt=true.8507648013190143204243292341401455472520576666705791844905927948100610591098114412031243127813101360140814441486153915901644169317451797184718961928198620182055211621492181223922922309