530
1075582226014562116174
Ces37077936014570127174
Urol39067936014578115180208
2018;41397936014562121176230253
22(2):44187936014561121152210240262
106–11447067936014561116178241295343396
ORIGINÁLNÍ3862207016996181224324367468561635735777
PRÁCE4677207016983165262348424
vosti,624898013150107148183205223
nykturie871898013167114161198256288310363
a1259898013158
inkontinence.134189801313189135192251283306364417475524576593
Solifenacin1958898013160118142164192245303352401423481
neměl2463898013168121211264287
žádný624104801314495154212258
významný9061048013153105152211259348406452
účinek13851048013159107129186239285
na16971048013159108
postmikční18321048013161120160195284306351398456477
reziduum2333104801313688132155214271328417
či624119801314971
vyšší7201198013158111152192214
riziko958119801314164109132177235
retence1217119801314193127179237287338
moči15881198013191150200222
nebo18341198013168121182242
jakýkoli2100119801313281127179226284307329
účinek24541198013167116138196250296
na6241348013159108
průtok753134801316193151184240287
moči.10611348013190149198219238
Solifenacin13211348013151109132153182234292341389411469
byl18111348013161108131
v19641348013150
této2038134801313182115171
studii2233134801313973131191212234
dobře24891348013159117178210261
tolerován.624149801313490113166197254302352410429
Závěr:7741643013564123178235276304
Studie1110164801315285145206229284
ukazuje14191648013169116169215276299354
statisticky1798164801315187138172195236272295345392446
významné22691648013160114162223274366426481
zlepšení624179801314569123185226280340363
téměř1012179801314395186241272
všech13091798013160101156207266
hodnocených16001798013169128190250310361413473520569629
parametrů.22541798013170121154205296351385418478496
Podle6241948013156113174197251
výsledků9001948013159112153176230291338397
je1322194801313285
solifenacin14321948013150110133156185238297347397419478
vhodným19351948013158118178239298345437
léčivem2397194801313286136159209262353
pro624209801316194151
pacienty,7992098013170120169192245303335387401
kteří1224209801315593144176198
selhávají14472098013149103126184233281332354376
při18482098013169101124
léčbě1997209801313185135195249
jiným2271209801313153112158249
anti‑25452098013158117149171205
muskarinikem.6242248013190147186231282314336394415461512601620
KLÍČOVÁ6252534014770132164236320392464
SLOVA11162534014762123207279351
Antimuskarinikum,6242698013164122154176265322361406457488511569590635694782800
hyperaktivní14522698013159105166220252302347384406455514536
měchýř,20162698013190143192250296329342
solifena‑23822698013145103126147176228286334368
cin.624284801314971128147
SUMMARY6253134014762143243345423493561
Holub7743298013168125148203261
L,1054329801314968
Hušek11413298013168124162214258
P,1418329801315559
Košina14963298013154109148168225272
J,1791329801313450
Pacovský18603298013154101149203250290334384
J,2267329801313350
Broďák2336329801315485140200247291
M.26463298013184104
The6243448013151109161
impact8093448013119106164213261296
of1125344801315785
changing12293448013149106153210268290346404
antimuscarinics16533448013149106137158246302340388437467489546567614655
on23273448013158115
quality24623448013159115163184205238288
of624359801315887
live73535980131194089141
in900359801311977
patients9973598013160110142164216274306347
with13643598013180102135193
overactive15773598013159107158190239288324346395446
bladder2043359801316184132192251304335
–23983598013155
results2477359801312880120176198231273
of624374801315987
the735374801313492145
VEST9043748013156108159212
trial.114037480131346588136159177
Primary7743893013561100127220276315373
Objective:11773893013577142171227277318345401456481
The16883898013151111164
authors18763898013158115149207265297338
present22383898013168100152192245303335
the25973898013142100153
results624404801313282121176197229269
of912404801315784
a10154048013149
multicentre,10834048013188144165197218265314370401431481497
noninterventional,15994048013158114171192248278328358409459516546567623680727749765
prospec‑2383404801315990145184241293341367
tive,624419801313456105157174
one-arm,8264198013158117170205253285374393
observational12474198013158118158211243296346378400457516565587
study1858419801314579137197245
into2127419801312784116172
the2323419801313896149
effect2496419801315886116168218254
of624434801315987
solifenacin735434801313897120141170222280328377399456
on12134348013158117
the1354434801313189142
quality15184348013159117165188209242294
of1833434801315987
life194443480131214271123
versus20884348013150102133174231270
previous2379434801316193145193216274332371
antimuscarinic6244498013150108140162250307347395445476499557578627
treatment.1275449801313465117165197286340398429448
Method:7744643013589144182242302364388
Satisfaction1179464801315098129150187215264311346366422479
with1676464801317899131187
treatment1886464801312859108155185272323379410
was23144648013178126164
meas‑24964648013188139186224254
ured624479801315890141201
by8524798013161108
Perception9864798013156106137184235295327350407466
of1478479801315987
Treatment1589479801315479130178210300353411443
Satisfaction20564798013153103135157196226276325361383441499
(TSVAS),25794798013132871386244948013157116169198214
Over8714948013175127180213
Active11084948013174123160183233286
Bladder-q1419494801316588138199259314346376439
Short18824948013161119179212250
Form21574948013160118151242
(OAB-q24244948013138110172228263326
SF)624509801315199128
and7735098013150107166
EuroQol9605098013151106137193267326349
Group13295098013169101157215274
scoring1623509801314190146177200257316
system1960509801314190130164215304
(EQ-5D-5L)2288509801312575147183234302337388434462
Results:7745243013563120167230259298346372
A11725248013164
representative1262524801313487148181233275329388421471505528578631
sample1918524801314395185245270324
of2269524801315888
the2382524801313695150
OAB25595248013174135191
population6245398013161121182242265315348371430489
was11375398013180130171
evaluated13325398013153103154177235285319371432
in1789539801312280
the1895539801313291145
study2066539801313975134194244
(20002335539801312880133189245
pa‑26045398013160111146
tients624554801313559114175209253
included903554801313393144169228290346409
in1338554801313394
6014585548013164121
centers16055548013159113173207261295338
in1969554801313393
the20895548013144105160
Czech22755548013174123177229290
Re‑25915548013166122159
public,6245698013161120180205227276296
14819435698013153101157206
patients11715698013161112145168222281314356
completed15505698013149106197257281335369421483
all205556980131507396
521745698013154
evaluations22505698013153103154177235285318342400460500
and6245848013151111173
1,892823584801316478136190243
patients10925848013171123158182237297331375
had14935848013170121183
baseline17025848013171124166221246269329385
and21135848013160121183
at2322584801316094
least2442584801313489139181218
126865848013164
post-treatment).6245998013161121162198228262295348397430520575634667695711
Improvements13615998013126116177210268317370460514573606649
in2035599801312685
QoL21485998013174134185
and23585998013153112172
OAB25595998013174135191
symptoms624614801314294188250285344437479
were11396148013181136170224
observed13896148013170133175231265321375438
over18546148013169120174208
a20886148013161
period21756148013172129162187248311
of25126148013170100
1226396148013164111
months6246298013189147206238296335
in984629801311977
the1085629801313189142
population12486298013160119180238260309341363421480
of1749629801315886
patients18576298013160110142165217275307349
treated2230629801313163114163195246306
with25586298013178101134192
solifenacin6246448013141100125147177230289339388411470
5–1011196448013157113160208
mg13556448013190151
and15316448013153112172
previously1731644801316194147197220279338379402451
treated2207644801313770122171205257318
with25536448013179103138197
other624659801316095156212246
antimuscarinic8966598013161122156180273333375426479513537598622673
agents.15956598013161124180240275319341
OAB-q19726598013175139196233298
SF22966598013162113
scores,24356598013152104163197252294315
including624674801312380129151208268290347407
Total10526748013151102134184207
HRQoL12806748013169123196255304
Score,1606674801315099155187239256
all188467480131497294
HRQoL19996748013169123196255304
subscores2328674801313794153193242298330382422
and6246898013150109169
Symptom8196898013158104195256290347438
Severity12826898013158113162215248272306358
Score,16666898013158108165198251269
all1960689801315781103
improved20896898013130120181214271321374435
over25496898013166116169201
the624704801313493147
study797704801314480138199248
period.10747048013161116148172231292312
Changes14157048013163121171230291345386
in1826704801312785
TS-VAS19367048013155107142197256309
scores2270704801314595152185238279
also2574704801315477117176
demonstrated6247198013160113203262322362397430481514565626
improvements12757198013121110170203261310362452506565597640
in1940719801312079
overall20417198013158107160192243266289
QoL23527198013174133183
over25587198013158107160192
the624734801313495150
study800734801315187147209260
period.10867348013171127160184245307328
The14407348013161123178
EQ-5D-5L16447348013162137174228298336389437
showed21077348013151111171252307369
shifts25027348013151111134164204248
towards624749801313491171222254314354
improved10037498013132122183217274324377438
QoL14767498013174134184
for1686749801313896129
all1841749801315982105
dimensions.1971749801316992183237296337359418478519539
Data25457498013171121154205
from624764801313066126220
3-day8717648013165100166218268
bladder1165764801317399151214277333368
diaries1559764801317296148182207263307
demonstrated18927648013172129222284346389426461514549604668
im‑25867648013134127164
provements297689801316093150199251340394452485527
in352889801312078
OAB3628898013173134189
symptoms384289801313888178238271328418458
over4322898013158107159191
the453889801313189143
course4703898013149105163195237290
of501589801315888
the2976104801313492146
study,3147104801313873131191240254
including3426104801312078127150208268290348408
frequency,3859104801312660112172230284342391443457
urgency,4338104801315890148202260310361375
nocturia47351048013159117168204263295318367
and29761198013150109169
incontinence.3171119801312482132189249281305363417476526578596
Solifenacin37931198013152111135158187241300349399422481
was43001198013179130171
well44971198013180133157179
tolerated4702119801313592116170202253287339400
in2976134801312384
the30861348013144105161
current32731348013160120154188243303337
study3637134801315188149211262
with39351348013181105141202
only41631348013170131155206
1543951348013164112
non-serious,45331348013170131192228271327361385446507548569
mild29761498013190113136196
adverse31961498013150111161214247289343
events35631498013154103156215248291
reported,3879149801313284145205238276329390409
mainly43121498013190140163222245294
dry4630149801316092145
mouth48001498013190149208243302
(n=12).2976164801312985152199245272288
Solifenacin32891648013160120144167196249309358408431490
did3804164801316992152
not39811648013168128161
have41681648013168117166219
any44121648013159118165
notable46031648013168127161211272296350
ef‑4979164801316291123
fect2976179801312982133170
on31731798013158118
post-void33181798013160121162197227278336359419
residual3763179801313486127150210268318341
volume,41301798013151109133191281335353
risk450817980131345898144
of4679179801315988
urinary4794179801315891114173223255308
retention2976194801313285119171230263286345405
or3407194801315992
any35241948013151110157
effect3707194801315484113167217254
on39881948013158118
urinary4132194801315891115173223255308
flow4467194801312653112191
rate.4683194801313485118170189
Conclusion:31262093013566127192242271334381410473537562
The37202098013152113168
study3912209801315186145206255
shows41922098013150109169249290
statistical4507209801315086136169192232268291340391414
im‑49462098013132122156
provements2976224801316193149198249338392449481523
in3523224801313188
all3635224801315880102
parameters37612248013168118150200288342375426457498
evaluated.42832248013161110160182239288320371431450
Accord‑47652248013164112158214246304337
ing2976239801312381140
to3140239801313490
the3254239801313593146
results,3424239801313384124181203236278296
solifenacin37442398013142100123145173225283332380402460
is4228239801312362
a43142398013150
suitable4388239801314298120153203263286339
drug4751239801316091149209
for4984239801312986118
patients29762548013161112145167221279312354
who33632548013180139198
fail3586254801313789111133
treatment3744254801314275127176208299353412444
with42212548013180103137196
other44412548013168100159213245
antimus‑47112548013158117149172262320359391
carinics.2976269801314999130153210232280322341
KEY29782984014770134206
WORDS321129840147105189260345408
Antimuscarinics,29763148013164122154176265322361410460491514571593641683701
overactive37023148013158106158190240288324346396447
bladder,4174314801316083132191251304335348
solifenacin.45463148013142100123144173225283332380402459478
………297634340147120240360
ÚVOD29783858018197183286388
Hyperaktivní29764198013170120182237269320367405427478538560
močový35694198013192152202259308362
měchýř39644198013191145196255302335
(OAB)43244198013138110172228255
je4603419801313386
relativně4714419801314194117167200223273334388
časté2976434801314896135168218
onemocnění32124348013158115166253310358414466522542
(postihuje3777434801312583141180213234290345367418
více4214434801314870117166
než43994348013158109152
10%4570434801315399191
světové4779434801314190140171226273323
populace)29764498013161120180238260309358409434
a34344498013150
může35084498013191148191243
mít37754498013190112145
negativní39454498013159112172221253275324383405
dopad43744498013160118178228288
na46864498013159108
kvalitu48184498013147100149172193226284
života2976464801314467116173205255
(QoL)32554648013136107166215243
(1,352246480131368495
2,3642464801316078
3).3744464801316185100
Mezinárodní38764648013185138183206263312343400460518539
společnost44404648013148107166189242291349407447482
pro49464648013168100156
kontinenci29764798013146103161193214272324382430452
(ICS)3452479801312547109160187
definuje36604798013159112137164221278300352
OAB40324798013174134188
jako4244479801312068113169
„urgenci4437479801312986117174227284333354
s48114798013141
nebo48724798013159112171230
bez29764948013161115159
urgentní3160494801316697155208266298356378
inkontinence,3562494801313189134191250282304361415473521572589
obvykle41754948013167127175227274298351
se45504948013149102
zvýšenou46774948013152105157197250308367425
denní29765098013162117177238261
frekvencí3262509801314074128176231285346397420
a37075098013162
nykturií“37945098013170119167206266299323347381
(4,4200509801314092110
5).4336509801316593110
Definice44815098013173129157184244267318371
platí,4878509801317296147181205224
pokud29765248013162122169229290
není32905248013169123182204
potvrzená35195248013170131164217251298351410460
infekce4004524801313290119172219267319
nebo43485248013168122183244
jiná4617524801313254113163
patrná48055248013170121154187247297
patologie29765398013161111143199222280340362415
(4).3415539801312978104119
Antimuskarinové31265548013166126159182274333374420473506529589649699753
preparáty39045548013171104157219271303355389442
jsou4371554801313373133193
v45895548013160
současné46745548013151111171221272314373428
době29765698013160118178232
základem3232569801314899145169217277330419
farmakologické3675569801313383114204253299355379437497519567612664
léčby4363569801312780129189236
symptomů4623569801314594184244276332422479
OAB.29765848013174134189208
Léčba32075848013149101150210260
však3490584801315090140185
může36995848013190147190242
být39645848013161108145
u41335848013158
mnoha42145848013190148206265314
pacientů45515848013161111159181234292323381
ne‑49555848013159112147
dostatečná29765998013160118158193243275326376434483
kvůli34835998013155108166188210
nedostatečné37175998013167120181239279314364396447497555608
účinnosti,43495998013167115137195253311351386408426
špatné47995998013149109159191250303
snášenlivosti2976614801314199148188241299322344393450491526548
a/nebo3548614801315898154207267327
špatné38996148013150109160192251304
compliance42276148013158114204264287309358416465516
(6).4767614801313888115130
Pře‑4921614801316494146181
chod29766298013149107165225
od32286298013158119
jednoho3371629801312678138196254313371
antimuskarinického37666298013153110142164253310349394445476499557578627672724782840
léku4630629801312678124182
k48366298013149
jiné‑4909629801312648105158193
mu29766448013191149
u31506448013167
pacientů32416448013170121170192246305337395
se36616448013150104
suboptimální37896448013150107168228289322345435484507565587
odpovědí44016448013167129189249298351412434
nebo48596448013168122183243
nežádoucími29766598013159112156207266324382431453542563
účinky35616598013159107129186232283
může38666598013190147191242
zlepšit4130659801314568120180220241275
symptomy4429659801313988178238270326416462
OAB49136598013174135189
a29766748013150
poskytnout30506748013161120160205257294352410468502
zlepšení3576674801314467120180220272330352
kvality3952674801314799149171193226277
života4254674801314466116173205255
(7).4533674801312981110125
Solifenacin31266898013151110133155184236295344393415473
je3623689801313285
antagonista37336898013158116148198258317376397437472522
muskarinových42876898013191148188233285316339397456504557605663
re‑4974689801314193128
ceptorů,29767048013149100160192248280338356
který3356704801314884135167219
byl35997048013161108132
schválen3755704801314290148195245267320378
v41577048013151
USA42327048013169117179
a44367048013150
Evropě4511704801315199132188249302
v48377048013151
roce4912704801313390139190
2004.29767198013154105160216233
Je3233719801313588
prokázáno3342719801316092149195246291341399457
zlepšení3820719801314467120180220272330352
příznaků4193719801316092115158217266311369
OAB,45837198013174134189207
včetně4810719801315097148181239292
inkontinence,2976734801312381127184243276298356410468517568585
urgence3586734801316798157210269318369
a39797348013159
frekvence,4062734801313771123169222274333382433450
s45377348013149
nízkým4610734801316890134181233324
vý‑49587348013158111144
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