538
116201226014562110164
Ces8507936014570127174
Urol10497936014578115180208
2018;12827936014562121176230253
22(2):15617936014561121152210240262
115–12118497936014561109162223276327382
ORIGINÁLNÍ852207016996181224324367468561635735777
PRÁCE1667207016983165262348424
matické850898013193144178202253301355
biopsie123189801317599159222265288343
prostaty.1600898013175109168210247299333387402
Ve2028898013170122
2112176898013167117160
případech2362898013175109133195247310365417478
se2866898013154110
jednalo850104801312375134191239260317
o11871048013158
primobiopsii,1264104801316091113201258317339396455494515536553
v18361048013150
1741905104801315396141
případech2065104801316091113171220279331379436
o25201048013158
rebiopsii.2602104801312878137159216275314335356374
Vyhodnocena8501198013156105164222283340399448499557606
byla14851198013161108131180
frekvence1689119801313467119164217269327375426
záchytu21391198013150101149207253290348
karcinomu25111198013152103134181203260318408465
prostaty,850134801316193149189224273306357370
jak1244134801312270115
klinicky138213480131467092149171219265316
nesignifikantního,17201348013159113153174233291313338365410461519551609630691749766
tak2510134801313281127
klinicky265913480131477192150172220265317
signifikantního850149801314162121179201227253298349407439497519579637
karcinomu1511149801314899131177199257315404462
(KSCaP)1997149801313184137199249303329
pomocí23521498013161120209268317339
cílené271514980131517397150208261
biopsie850164801316183141201241263315
(CB)1189164801312888142168
a13801648013150
systematické1454164801314089130165216305353386408456501553
biopsie2030164801316183141201241263315
(SB)2369164801312876129155
v25481648013149
podsku‑26201648013161120181220265323356
pinách850179801316183141190238296
primobiopsií1170179801316193115204262323345403463503525546
(PB)1740179801312984137163
a19271798013150
rebiopsií2001179801313284144166224284324346367
(RB).2392179801312984139165180
Výsledky:10001943013568126174204263331389450478
V15141948013158
detekci15981948013174129164218266315339
KSCaP19631948013169125189242298
bylo22871948013175125150211
dosaženo25241948013174134177230276330391452
statisticky850209801314278130164187228264288338386439
signifikantního1315209801315173135195218245273320373433466527550613673
rozdílu20142098013142101145205228254313
při23532098013171104128
provedení25072098013171104163214268330386446469
kombinace8502248013147105196257280339389438490
CB13652248013172126
a15162248013159
SB16002248013160114
oproti17382248013168129162220253276
SB20382248013160114
pouze21772248013170130189234287
ve24892248013158111
skupině2625224801315096155215238297351
rebiopsií850239801313284144166224284324346367
–12412398013155
35,113202398013154104120166
%15102398013181
vs.1615239801315090110
25,317492398013153106122176
%,19492398013181101
p=0,047.20742398013160140207224278333381388
V10002548013158
detekci10842548013174129164218266315339
nesignifikantního14492548013173129171194256317340368395442496556590651675737799
karcinomu22732548013161114147197220280341435495
sys‑27932548013155107150183
tematická850269801313587178229262285335381433
biopsie1308269801317194154215257279333
dosahovala16662698013169129170222281341391442465515
statisticky2206269801315186137171194234269292342389442
signifi‑2673269801315072133192215242269303
kantně850284801314797155187245298
vyšší11712848013150102142181203
frekvence1398284801312861112158210262320369420
detekce18412848013159112145196242289340
než22042848013159112156
cílená238328480131497195148206255
biopsie2661284801316083141201241262315
v8502998013150
obou9202998013158118177234
poskupinách11742998013161120159204262321343401449497555
(PB1753299801312579131
a19052998013149
RB)19742998013156111137
–21312998013155
FB22062998013150103
11,92329299801315494106155
%25042998013181
vs.2605299801315090109
4,72734299801315470122
%,28762998013181100
p=0,008;8503148013161140207225278333387404
RB12783148013156111
13,81413314801315499116171
%16083148013181
vs.1713314801315090110
6,91847314801315472122
%19933148013181
p=0,034.20983148013161140208225278328382400
Závěr:10003293013563120175231271297
Data13293298013172121154204
naší15583298013168117158180
prospektivní17623298013170102160200260315362399422472531554
studie2340329801315085144204226280
ukazují,26443298013167113165210269292314332
že850344801314496
záchyt9703448013152103152209255293
nesignifikatního12873448013167120160182241298320346373418469501559581641699
karcinomu20103448013155106137184206263321411468
prostaty25023448013169101158198232282314365
je2892344801313184
nejvyšší8503598013159112134183235276315337
v12113598013153
případě1291359801316192115174224284336
systematické1651359801314594134169220309358390412460506557
biopsie2236359801316083141201241262315
a25753598013153
nejnižší26553598013159112134192214257299321
v8503748013150
případě924374801316192115174224284336
cílené128437480131497196148206259
MRI15683748013185140163
fúzní1755374801312988132191212
biopsie.1991374801316184141202242263315333
Cílená1000389801316284108160217266
fúzní1289389801312583127185207
biopsie1516389801316082139199239259312
v18473898013150
kombinaci19173898013146102191250272329378426447
se2384389801314193
systematic‑2497389801314190130164215303351383405453479
kou8504048013146101158
biopsií1027404801316082138197236257278
dosahuje13244048013159116155204260316338389
signifikantně1732404801314161119175196221248292341398429486537
lepších2293404801311970129167188235291
výsledků26044048013149100139160212271315372
detekce8504198013160113146197242290340
KSCaP12154198013158111173223277
oproti15204198013158118150207239261
samotné1806419801314494183242274332385
systematické2215419801314594135169220309358390412461506558
bio‑2800419801316183141176
psii,8504348013161101122144161
ale1036434801314972124
pouze11854348013160119177222273
ve14824348013150102
skupině1608434801314186144203226284336
rebiopsií.1969434801313284143166223284324345367385
KLÍČOVÁ8524634014770132164236320392464
SLOVA13434634014762123207279351
Karcinom8504798013155106137184206263321411
prostaty,1291479801316092149189223273305356369
diagnostika,1690479801316082130189247305345380402447498516
MRI,22364798013186140163181
biopsie2447479801316183141201241263315
pro‑2792479801316092149184
staty,850494801314176125157209222
fúze.1096494801312987132183200
ABSTRACT8525234014776146210275345425494562
Záleský10005398013159109131184224269321
M,13485398013186105
Stejskal1477539801315485136158197242293315
J,1816539801314258
Minárik19025398013185108165214245268313
I,2239539801312644
Koldová23115398013154111134194252300350
M,26885398013186105
Ad‑28205398013164123156
amcová8505548013150139188243292342
V,1216554801316274
Votrubová13145548013162117149181239299358406456
J,1794554801314561
Pavličko18805548013161109157180202250295351
A,2262554801316485
Babjuk23715548013162112172194251296
M,26985548013185105
Za‑28275548013166115149
choval8505698013149107166214264286
R.1161569801316385
Comparison12705698013171127217277327358381420479537
of1832569801316695
detection19515698013168121154206255292314372431
of2406569801316695
significant2525569801314971130188210236263311361419451
and8505848013150108167
insignificant1041584801312482121143202259281307334382432490521
carcinoma15865848013151100132178200258316406454
using2066584801315897119176236
systematic2326584801314291132166217306355387409457
and28085848013151108168
targeted850599801313484115173226259310370
MRI/TRUS12445998013186140163202258314382430
fusion1698599801312988127148206265
prostate1987599801316092149189223273305356
biopsy.2367599801316184141202242291304
Major10006143013592149177240279
statement:1303614301355393150188244339396460498524
Detection18596148013172126160211261298320379438
of2322614801316796
insignificant2442614801313190129151211269291318345394444502535
prostate850629801316296155197233284318371
cancer12476298013159110170221274307
by15796298013171120
systematic17256298013151102144180234326377410434484
biopsy2234629801317195155218260311
is2570629801313373
signifi‑2669629801315173135195218245272307
cantly850644801314999157188211259
higher1134644801315981140197251282
than1440644801313593142200
by16656448013161108
targeted1797644801313585116174227260311371
MRI21946448013185140163
fusion2381644801313089128149207266
biopsy.2672644801316183141201241291304
Targeted850659801315193125183236269321381
biopsy1255659801316992150211251301
in1580659801313189
combination16936598013158114204264287344393426448506565
with22906598013180103136195
systematic2509659801314999140174226315364397419467
biopsy850674801316183141201241291
reached1165674801312980128177235288348
significantly1537674801313859118176198224250299349406438460508
higher2066674801315981140198251282
detection23696748013160113146197246282304362421
rate2814674801312979111162
of850689801315988
clinically963689801315881103161183233283306328377
significant1365689801315071131190213239266315366425457
prostate18476898013170102160201236286319371
cancer22436898013158108167217269301
than25686898013143102152210
sys‑28036898013150100141173
tematic850704801313485174223255277325
biopsy1199704801316184141202242291
in1514704801312381
the1619704801313492145
rebiopsy1788704801313284144166224284324374
group.2186704801315991147205265282
Introduction1000719301352994132172235300364414456484547611
and16347193013565128193
objectives:18597193013563128158215266308336393449496522
Detection24127198013172127161213264301324383442
of2879719801316897
insignificant850734801312381120141200258280306332381430488520
cancer13947348013152102160208259291
is1709734801312665
one18017348013158117170
of1998734801315887
the2109734801313795148
major22847348013190139161219251
problems2562734801316193149209233285374414
of850749801315886
PSA-based9557498013154103164196255304343395454
prostate1429749801316091147186219268299349
cancer1798749801314897154201251282
diagnostic2099749801315980128186243300339373394441
algorithm2560749801314971129186217239272329416
with8507648013179102135193
subsequent10677648013146102162202255315372425483515
systematic1606764801314594135170221310358391413461
prostate2095764801316193150190224274306357
biopsy.2480764801316184141202242291304
MRI28137648013185140163
with3203898013180103136195
targeted342389801314292124182235269320381
fusion382989801313796136157216275
biopsy412889801316992150211252302
should4454898013149107166225247307
increase478589801313189139170222271311365
the5174898013142101155
detection32031048013160113146197246282305362421
of3648104801315887
significant3759104801314162121179201227253302351409441
prostate4224104801316193149189224274306357
cancer.4605104801314999156205256287301
The33531198013152114170
aim3549119801316084175
of3750119801316999
this38751198013144105128169
bicentric4070119801317296146200260294328352403
prospective44991198013171105164206267324376414438489543
study5068119801315288148210261
was32031348013179130171
to3399134801313997
compare35211348013154111202263314346399
detection39451348013165119153205256293316375435
rates4405134801313889122174215
of4645134801316494
clinically4764134801315477100159181231282305328377
sig‑5166134801314669129163
nificant3203149801315981108135184235293326
and35511498013150109169
insignificant3745149801312079119141201260282309336385436494527
prostate4295149801316093150191227277310362
cancer4680149801314899158207259291
by49941498013160108
MRI/51251498013185140164204
TRUS32031648013151108177226
fusion3454164801312787128150209269
targeted3748164801313283115174228262314376
biopsy4147164801316185143205246296
(TG)4468164801312884150178
and46701648013150108169
systematic4864164801313990131167219309359392416465
biopsy3203179801316184143205246296
(SB).3524179801313179134161177
Materials33531943013591147185241280308363391437
and38101943013556119182
methods:40131943013594150189252313378423449
MRI44821948013186140163
was46671948013180129169
performed48581948013161115146178235267357410471
on32032098013159117
41933442098013159105150
patients35232098013161111143165218276307349
based39022098013161111150203264
on41902098013164122
a43362098013156
suspicion44162098013147103142202224272294352410
of4851209801316492
prostate4973209801316092149189224273305356
cancer3203224801314998156204254285
linked351222480131204198143195254
to3790224801313086
elevated3896224801315376128176226258308368
PSA42842248013155105167
levels.4475224801311972120171194232251
MRI47462248013185140163
was49292248013179128167
posi‑51172248013160119159180212
tive3203239801313558110164
in3392239801313292
38535102398013164118172
patients,37072398013171123157180235295329372392
the41252398013143104159
first430923980131366496139175
biopsy4510239801317195155217259311
group48462398013170103162222284
(FB)5156239801313890145173
had32032548013159108167
21133912548013154101142
and35542548013150107167
rebiopsy3745254801312981141163221281321370
group4136254801316092148206266
(RB)4426254801312680135162
had46092548013159107167
1744797254801315497143
patients.49612548013160110142165217275307348368
A32032698013164
subsequent3287269801314096155194247306363415472503
TG,38102698013151115134
followed3968269801312581104125182260311371
by43582698013161107
a44852698013150
SB45542698013151103
was46772698013179128167
performed48642698013160114145176233264353406465
on32032848013159117
these3344284801313492145185239
patients.36072848013160110142165217275307348368
Results:33532993013561116160220246283328352
In3721299801312378
detection38172998013159110141190238273293349406
of4240299801315784
significant4342299801314060117173193218244291339394425
prostate4784299801316090145183216264294344
can‑5145299801314896152184
cer32033148013149100131
a33583148013156
statically3438314801314882132164186234284306328376
significant3838314801314768127185207233259308358415447
difference4309314801316688117147199230282340388439
was47783148013180129169
reached4971314801313990138187245298358
for3203329801312986118
TG+SB33453298013157122186230283
against36523298013155114163185243282316
SB39933298013156109
in4126329801312886
rebiopsy4236329801313889149171229289329379
group4644329801316091148206265
–49333298013161
35.150473298013159109126172
%52483298013181
vs.3203344801315090110
25.333373448013153106123177
%,35383448013181101
p=0.047.36633448013161140207225278334382389
In3353359801312483
detection34613598013170125159211263300323383443
of3929359801316898
insignificant4052359801313291132154215275297324352402453513546
prostate46233598013170103162203239290323376
cancer50243598013159110170220272305
the3203374801313493147
systematic3375374801314999140175227317367400422471
biopsy3871374801316992151212252302
had41983748013168117177
a44003748013159
significantly4483374801315072131190212239265315365424456479528
higher5035374801316890150208262294
detection32033898013160114147199249286308366426
rate3653389801314192124176
than38533898013143101151209
targeted4087389801314292124182236269321382
in4493389801313290
both46073898013170130162221
subgroups48533898013149106166228259317375435476
(FB3203404801312978131
and33574048013150108167
RB)35474048013156111137
–37074048013155
FB37854048013151104
11.93912404801315394106157
%40924048013181
vs.4196404801314990109
4.74328404801315471123
%,44744048013181100
p=0.008;45974048013161140208226279334388405
RB50254048013155111
13.85158404801315499116171
%32034198013181
vs.3308419801315090110
6.93442419801315473123
%35894198013181
p36944198013161
=37794198013166
0,034.3869419801315371124174228246
Conclusion:33534343013564123184232259320365391452513537
Detection39084348013170123155205253288309366423
of4350434801315885
insignificant4458434801311975113134192248269294320368416473504
prostate4981434801315991146185218267298348
cancer3203449801314999157205256287
by35124498013160108
systematic3644449801313887128162213302351383405454
biopsy4119449801316183141201241291
is4434449801312059
significantly4517449801313860119176198224251299349407438461509
higher5047449801315981140198251282
than3203464801313492141199
by34264648013160108
targeted3558464801313483115172225258309370
MRI39524648013185140163
fusion4139464801312988127148206265
biopsy.4428464801316083141201241290304
MRI/TRUS33534798013185138160198253308375421
targeted3798479801312978108165217249299358
biopsy4175479801316082139198237285
in4484479801311875
combination45784798013148103191250272328376407428485542
with51404798013178100132189
systematic3203494801314189129163214302350382404451
biopsy3674494801316083140199239287
had39814948013159107166
a41674948013149
significantly4236494801314162120177198224250298347404436458505
higher4761494801315880138195248279
detec‑50594948013160112145195244270
tion3203509801313456114172
rates3399509801313585118169209
than3632509801313795143201
systematic3857509801314493134168219308357389411460
biopsy4343509801316184141202242291
in4658509801312683
the4765509801313795148
repeated4937509801313587146200248281332392
biopsy3203524801316183141201241291
only.35185248013158117139187200
KEY32045534014770134206
WORDS343755340147105189260345408
Prostate3203569801315586142182217266299350
cancer,3577569801314999157205256288301
diagnostics,3903569801315981130189247305345380402450492510
MRI,44385698013185140163181
prostate4644569801316193149189224273306356
biopsy,5025569801316183141201242291304
fusion.3203584801312988127148206265283
………320361340147120240360
ÚVOD32056558018197183286388
Současný32036898013151109166214263303360405
diagnostický3628689801316081129188245303343377399447492543
algoritmus4191689801314971130188219242275364420459
karcinomu4670689801314697128174196253310400456
pro‑5146689801316192148183
staty3203704801314176125157209
založený3436704801314798120178220272330376
na38387048013159108
detekci39737048013160113146197243290311
elevace4308704801315779132181231279330
PSA46657048013155105167
a48567048013153
následné49367048013159108147169222282340393
systematické3203719801314190131166217306355387409457503554
biopsii3781719801316992149210250271293
prostaty40987198013169101157197232282314365
trpí4487719801314274135157
několika46687198013167120166222246267312363
nedo‑50557198013167120181239274
statky.3203734801314176125157203255268
Přes3353749801315586137177
zvyšující35547498013151104156197253276297345367
se39457498013148101
počet40707498013168127176227260
biopsií4354749801316890148208248270291
a46697498013157
také4750749801314191137188
zvyšující49627498013152104156197253276297345367
se3203764801314194
počet33257648013161120170220253
odebraných36077648013158119172231263313371417464522
bioptických4158764801316083141201234256304349401448506
vzorků46887648013154101157189235293
při5010764801316092114
bio‑5153764801316183141176