501
3175586226014562115166
ORIGINÁLNÍ3862207016996181224324367468561635735777
PRÁCE4677207016983165262348424
Ces36997936014570127174
Urol38987936014578115180208
2019;41317936014562121176229253
23(4):44097936014562122153210240262
316–32446977936014561115169233291348405
rezistentní62489801313285131154195230282341374433456
zejména1105898013152105128218272331381
vůči1511898013157117165187
ciprofloxacinu172489801315679139173230257284343390440490513571630
(58,4237989801313688141161214
%),2626898013181108124
přes624104801316397152195
čtvrtinu8461048013162101157192232257318379
izolátů1252104801313582142168220255316
však15951048013162106159208
také1830104801314699148203
na20601048013172124
amoxicillin‑klavulanát,22111048013162156218267292344368393417441502429496589342949659124294965908429496595042949659864294966038429496605642949661074294966165429496621542949662484294966270
cefalotin,12121048013178132163218244306342368430452
cefuroxim,16921048013179134166230265326377403498519
cefotaxim,22391048013180135167230266321373400494516
ceftazidim,6241348013150103132172224270295356380471491
kotrimoxazol,11401348013157116150184208299360407459505564589608
ofloxacin,1774134801316996123183231282333357416436
piperacilin‑tazobaktam223613480131719515721324629834937239641947942949658674294965872429496589942949659204294965964429496601342949660554294966096429496613042949661794294966266
a12281348013152
tetracyklin.1304134801313688121153204253304351376398456476
Zachytili18081348013159110159218264303326349371
jsme2204134801312767156210
celkem24391348013152104128174226316
155624164801315397145
polyrezistentních7901648013160118141189221272316339378412462519551609630678735
baktérií.15461648013159109154190241272294316334
Většinou19011648013155105138179200257315372
šlo2297164801313759117
o24341648013158
střev‑2516164801313771103153202234
ní624179801315880
gramnegativní725179801315990140228286338398447479501550609631
tyče,1380179801313081128179196
jejichž160017980131207295117165222266
rezistence1890179801312980125147186221271329377428
byly23391798013160107130178
pod‑25381798013160119179212
míněny6241948013188110167219276322
expresí967194801315299158190241281302
beta‑laktamázy12901948013159113145195228252300345381430518566610661
s19751948013137
rozšířeným2036194801312985126168190224275332378466
spek‑2526194801313796149194224
trem624209801313467120211
(ESBL,860209801313990143197247268
n11542098013168
=12482098013175
108).13482098013163112167195211
Žádná15852098013169120181240291
z19012098013154
gramnegativních19802098013169102154244303358420470504527578638661711770
tyček624224801313486135187233
s8822248013143
výjimkou9512248013151105129152241288346405
P.1383224801315266
aeruginosanebyla1471224801315610313419024626832538041747219702248013159113174222246296
rezistentní2291224801313587133157197233285344376436459
vůči6242398013149108156178
meropenemu8252398013189143176233294348407461550608
a14552398013150
imipenemu.15302398013120110132192247306359449507526
Nezaznamenali20782398013170124170221266326375465519577627650672
jsme624254801312464153208
výskyt8552548013150103145191243282
S.1160254801314870
aureus12502548013155111142187243280
neboEnterococcus1553254801315911317423418112548013149104135180211265312365412456511547
sp.,23792548013137912466254801311938
které2529254801314583135168220
by6242698013161109
nebyly7592698013159113174222247296
citlivé1080269801315073108131154204257
vůči13622698013151110158181
vankomycinu.15682698013151102161207265356403452475533592611
Závěr:7742846013362115166219254277
Naše10812848013171120159212
údaje13162848013167126175196249
o15882848013167
prevalenci1685284801316294145194243265318375424445
a21542848013157
rezistencích2235284801314091136158196230281339388409457514
izolovanýchmikroorganizmů624299801312364117138193239286341384429484588608651682735791821876922977996103711241178
jsou1824299801311754109164
srovnatelné2005299801314068122167224270299348368422473
s24942998013140
údaji25512998013157114160180199
v6243148013150
zahraniční697314801314696153183232288309356412433
literatuře115331480131264678128158207238295325375
a15513148013152
potvrzují16283148013161119150202233278335356377
vysokou20283148013152103142199245300357
míru24103148013190111141198
re‑2631314801313585119
zistence624329801314466104137187244291341
vůči9873298013150107153173
řadě1183329801313280139190
běžně13953298013161113157214266
používaných16833298013160118175218240288336393438484541
antibiotik.22463298013150107137158217238295326347391411
KLÍČOVÁ6253584014770132164236320392464
SLOVA11163584014762123207279351
Infekce624374801312484113167214263316
močových9743748013192153204262312366415475
cest,14743748013159112154190210
uropatogenní17093748013169101160222274308366428483543603626
bakterie,23603748013171123170208261294318372390
rezistence,624389801313284129151190225276334382433450
antibiotika,10983898013150107139161221243301333356401452470
ESBL.15923898013151103156204224
SUMMARY6254184014762143243345423493561
Hrbáček7744348013169102164215265317365
J,1164434801313655
Čermák12434348013162115148239289337
P,1604434801315461
Hanáček16894348013168119178228278331378
V,2091434801315569
Adamcová21844348013164123174264314372421473
V,2681434801315569
Bartáková6244498013155106138176227273331380430
L,1078449801314869
Zachoval11714498013158109158217276325376399
R.1594449801315477
Prevalence1694449801315586139188239262316375424476
of2193449801315888
uropatho‑2304449801315790147208259292351410446
gens6244648013160115175217
in867464801312282
urine974464801315992117177232
and12324648013150110171
their1429464801313494149173207
resistance1662464801313285128151192229281341392445
patterns:21324648013161113148186239273334376395
data25534648013160111145197
analysis6244798013150110161185235278302343
from993479801313166125217
a12364798013152
single1315479801314366126188212267
centre.16084798013152105165199233286306
Introduction:774494601332687123158218281342391430455515577598
Antibiotic14034948013165123155178237260318351373422
resistance1849494801314193134155194229279337386438
is2311494801313171
a24064948013158
major24974948013190139162220252
issues62450980131236099153205244
in891509801311874
contemporary9845098013148102159190239326384441472520551601
health16045098013157109156177209265
care,1888509801314896126176192
including2103509801311874121142198256276332390
in2516509801311874
the2613509801312986137
speciality6245248013141100154204225274296317351402
of1049524801315987
urology.1160524801315889146169227287336349
Multi-drug15325248013186143166199221254316347405465
resistant2021524801313183123144183218267325357
bacteria24015248013161111160196247278301349
are624539801315081132
now7765398013159117194
commonplace9915398013148104193282340398457480528576627
not16385398013159117149
just1811539801311976115149
in1984539801311976
the2084539801313088141
hospital22455398013159116156215237270320342
en‑26075398013153110143
vironment,624554801315073104160219308361419450469
but11165548013161119152
also1291554801315072111169
in1484554801312179
the1587554801313290143
community.17535548013149105194283340398420453505518
The22935548013151111164
objec‑24805548013158119141194243270
tive624569801313456105157
of805569801315987
thiswork916569801313492114153232290322368
was13085698013179129169
to1501569801313490
investigate1615569801312380127179219254276335384416467
the2106569801313492145
prevalence2275569801316193144193243265318376424475
of624584801315987
uropathogens735584801316698154214264297355413473526584623
and13825848013158116175
their1582584801314199153174206
resistance1812584801314092132153192227276334383433
patterns22705848013168118150187238269328367
in2661584801313189
our6245998013159116148
department.7965998013160113172222253290380433491523542
Methods:7746146013388142176234292352393412
Data12096148013171118148195
on14276148013158115
prevalence1565614801316090139186234254304360406455
and20436148013150105163
antibiotic22296148013149105135154212232288318338384
re‑2635614801313382115
sistance62462980131416198130178234281330
of982629801315985
uropathogenic1095629801315988143202250280336393451502558578625
bacteria17486298013161109156190239268289336
were21126298013179130159209
extracted23436298013160105140170218265299348407
from624644801312960114201
the847644801313288139
electronic1006644801315474125172206235290346366412
database14386448013160106136184241289326377
for1837644801312782112
the1971644801313288139
Department21306448013171123180228257292379430486515
of2665644801315985
Urology624659801316997152173228287333
for979659801312681111
the1112659801313288139
year1270659801314998144173
2017.14636598013154103149190195
Results:7746746013359112153211235269311332
A11236748013164
total1209674801312983114162183
of1409674801315885
203615126748013153103151201
individual1736674801311873131151199220278333380400
uropathogens2154674801315888142201249280336392451502558596
were6246898013179129158208
detected8496898013159110141190237272321379
between12456898013160112143222273324380
1st16426898013153168569040762444
January1752689801313279134189236266315
and20846898013150105163
31st2264689801315397235169040762444
Decem‑24186898013165117164213300331
ber6247048013160110138
2017.7757048013152100145185190
E.coli977704801314863118166186205
was11947048013178124161
themost1367704801313388137238293330361
common(n=726,17407048013148101186271326381406457534598647694710
35.7%),2462704801315399113161253275288
followed624719801312985107127184261313372
by10257198013161107
Enterococcus11617198013149102131173203254299350394436489523
sp.1703719801314395112
(n1838719801313690
=19577198013166
495,20467198013160109160175
24.322437198013161108124177
%)24507198013181105
and25787198013156113171
Klebsiella624734801315273118171206225269290310363
sp.1005734801313890107
(n1129734801312983
=12347348013165
206,13217348013154104158175
10.115177348013154100117162
%).17017348013181105119
A7747498013166
half8667498013172123147177
of10697498013171102
E.1207749801315070
Coli13077498013161115138161
isolates1494749801313576137162213247300342
were18747498013181136169223
ciprofloxacinresistant2123749801316285147181240268296356404456507530591624764801313385126148187223273332364
and10137648013158117177
3612157648013162116
%13637648013182
were14787648013180133165218
co-trimoxazol-resistant.1720764801315811515118421724033038943548653158861264667973177279483486991997810101030
Klebsiella297689801315478130189229249301323345393
sp.338889801314199117
were3524898013179131161212
markedly3756898013189138168214265324346393
resistant417389801312879118139178212261318349
to454589801313085
ciprofloxa‑465089801314970129160216241268325370419452
cin2976104801314971128
(58.43128104801313788140159211
%),33711048013181106121
over35171048013166114166197
a37381048013158
quarter38201048013167124173204241292324
were41751048013180132163215
also4414104801315880119177
resistant4615104801314091132153192227276334366
to5005104801314197
amoxicillin-clavulanate,297611980131501391982442663153373593804024604935455676166647227447938519009339841001
cefalotin,40011198013157108136187209268300322380398
cefuroxime,44231198013158109137196227284330353442495512
ce‑49591198013157108143
fotaxime,2976134801312987120171219242332386404
ceftazidime,34041348013158110139177228273296356379469523540
co-trimoxazole,39691348013157114150184216239329389435485531588612666683
ofloxacin,4677134801316794121179226276326348406425
piperacillin-tazobactam29761498013161831431972282783273483703924144715055385886326897497998488849331022
and40221498013150108167
tetracycline.4213149801313485119150200249300347369391448501519
A31261648013164
total3214164801314298130180202
of3440164801316694
15535581648013161106154
multi-drug37441648013190147169202224257319350409468
resistant4236164801314091131153192226276334365
pathogens46251648013168118150208267327380438477
were29761798013180133165217
detected.32171798013169122156208258294346407426
Most36761798013186145186221
of3921179801316796
them40421798013142101155245
belonged43111798013170124147206265325379440
among47751798013159149208267327
extended-spectrum2976194801315298134183239297348407439478535587635670701757844
beta-lactamase38381948013160112144192224247294341376424511558596648
(ESBL,4509194801312472122173220239
n47671948013157
=48431948013164
108)4926194801315398151176
positive29762098013161120160181215237286338
Enterobacteriaceae.33382098013151108140191223279339389438474525557579627676727775828845
No31262248013171130
gram-negative32802248013169100151241274334388449498531553603655
rod3960224801314198159
except41432248013162110158209269303
Pseudomonas44702248013164104157215275334424483542592632
aeruginosa29762398013151107140201262286346406448501
proved35022398013172106165215269332
resistant3860239801314296138161201238290350383
to42692398013144102
meropenem44062398013193148181240303359420475568
or49992398013169103
imipenem.29762548013124115138200256316372464484
There34852548013161124179212265
was37842548013182133175
no39842548013169130
vancomycin-resistant41392548013160112172222281373421471494554589623677719741782818870930963
isolates2976269801312361118140188219269308
of3303269801315886
S.3408269801315169
aureus34962698013149105136186242281
and37962698013149106164
Enterococcus39792698013151107138188218274322377425471527565
sp.4564269801314098115
detected.46982698013159111143193242277327386404
Conclusion:31262846013364122183232257317359384444505526
Our36732848013174132163
data38572848013160108141190
on40682848013158116
prevalence4205284801316193144193243265317375424475
and47002848013150108167
resistance48912848013129801211421812976299801313484141190241
of3237299801315887
uropathogenic3344299801315990146206256288346405465518575597645
microorganisms40102998013190111160191247306338396445502524563651691
are4721299801315081133
com‑48742998013149105195228
parable29763148013161112144195256279333
to3334314801314299
those34583148013143102161202256
from3739314801313771128219
the39833148013142101155
literature416331480131325488140172223256314346399
in4586314801313290
our47013148013168127158
geo‑48843148013169123183218
graphic2976329801316091140200258280328
area.3324329801315081132180199
They35433298013151111164211
confirm37743298013149105163188215246335
high4129329801315981140197
rates4350329801312978110161201
of4571329801315987
resistance4682329801312880120141180214263321369420
to2976344801313490
many30903448013190139197243
commonly33573448013149105195283342400423470
used3852344801315897150211
antimicrobials.40873448013150107139161250272320351408468491539561600620
KEY29783734014770134206
WORDS321137340147105189260345408
Urinary29763898013169100122180229260312
tract3312389801313365115164200
infections,3536389801312380108160210246268326384423442
uropathogens,4002389801315889146206256288346405465518576615634
resistance,4660389801313283124145184218268326374425442
antibiotics,29764048013150108139162221244301334356404446464
ESBL.34644048013152103156204224
………297643340147120240360
ÚVOD29784758018197183286388
Rezistence31265098013154108153176216251303361410461
mikroorganizmů36105098013188111156190247306339397446504527571661718
vůči43515098013148107154177
antibiotikům45505098013149107140163222246304337360406464552
patří29765248013161113147181206
mezi32115248013190146192217
hlavní3455524801316286137187248272
problémy3756524801316195154216242297388436
současné42195248013144104165215267309368424
medicíny,46725248013190146208232283307367415430
urologii2976539801315892151176236299323346
jako3349539801312475122181
obor35585398013158121182216
nevýjimaje.38015398013159114165220245269360411435490509
Po43375398013156113
desetiletí44785398013159115157212248272296351386411
byla49165398013160110135186
spektra29765548013141101157204242276327
rezistencí3329554801313083129153194230282342392415
běžných37685548013160116161221269318377
uropatogenních4169554801315891149210262295353414469528587610660719
bak‑49125548013160111158190
terií2976569801313487121146170
jako3172569801313485133192
Escherichia3401569801314988134192240273297344401425481
coli39045698013155109133157
(E.4083569801313887107
coli)42125698013155109133157186
nebo44235698013169125187248
Klebsiella4708569801315277125182220242290314338394
pneumoniae29765848013156115163221311368427450507556
(K.3554584801313891115
pneumoniae)36925848013165123172230319376435459516564593
stabilní4312584801315289142205230254315339
a46785848013160
předví‑47655848013172106161224276301337
datelná.29765998013161113149203229290342364
V33675998013168
80.34625998013166123143
letech3633599801313490127181234296
minulého39675998013191116177238263320381443
století4438599801315290149176232268293
se47595998013152109
však48955998013161105158207
mezi29766148013192148196222
gram‑negativními32256148013171106159252289352408472524559585637700724817842
(G-)40946148013140109147176
enterobakteriemi42976148013165126161216250310374428477517571606631687780805
rozšířily2976629801313291136180204241265290340
beta‑laktamázy33426298013166123158210245271322370409461552603650703
s40726298013146
rozšířeným4145629801313897141186209246300360408500
spektrem46726298013146108164212251285339430
(extended‑spectrum2976644801313084136177233296360418483520565629688742783819882976
beta‑lactamases,39806448013176135172226264292345398439493588641685743788810
ESBL).48186448013166122180233265284
ESBL29766598013152106162213
rozkládají32166598013143102147196223274337388413437
peniciliny,36806598013171128189213264289313337398446462
cefalosporiny41696598013159113144197222283326388450484510570619
a48146598013161
mo‑49126598013191152190
nobaktamy,29766748013160121185238286326379472521537
ale3540674801316186142
jsou3709674801313476137199
inhibovány3934674801313495156181243306357410471520
klavulanovou4481674801315885137187249274326387448500560621
kyselinou.29766898013147100143198223247307367427448
Existuje34506898013156107132173210270294349
ještě3825689801312882125161214
jiný4065689801312852112160
typ4251689801313892155
beta‑laktamáz,44366898013161117152204240266316364403455546597644666
tzv.2976704801313483138154
AmpC31567048013175166228294
beta‑laktamázy,34767048013171128163215251277328376415467558609656710725
které4228704801315696149183236
klavulanovou4491704801315783134184245269320380441491551611
kyselinou29767198013147100143198223247307367427
inhibovány3430719801312282142166227289339391451500
nejsou.39567198013158114138179240300321
ESBL43037198013151104159210
pozitivní45397198013161122167192227251303364388
mi‑49537198013190114149
kroorganizmy2976734801314884145208243305358420445492587637
zpravidla36407348013156120156210261287350376428
nesou40957348013171128172234296
na44197348013171123
svých45707348013152107162214275
plas‑4873734801317399151195229
midech29767498013190114175230282342
geny33447498013165120180228
pro35987498013166100159
rezistence3783749801313791137162203240293353404457
vůči42667498013155115164188
dalším44807498013165116140181205296
třídám480274980131387297158209300
antibiotik,29767648013150110144168230255315349373421444
především3449764801316094148210265316359383474
fluorochinolonům3949764801313160119179213272324384408467528553613674733824
(1).4799764801313281104121