546
346191226014562123185
KAZUISTIKY852207016976175264361404481560603687776
Ces8507936014570127174
Urol10497936014578115180208
2019;12827936014562121176229253
23(4):15607936014562122153210240262
341–34618487936014561122175229288349412
Na1000898013172121
prezentované115089801316294145189240298329385433482540592
kazuistice1766898013154104148206227265299320368419
vidíme220889801315779138159248301
zajímavou2532898013152102124144234282329386444
kompletní8501048013147101189246267317348404424
radiologickou1296104801313784142161217238294352371417460515571
regresi1889104801313786144173222260280
plicního2195104801316182101147203222280336
nálezu25571048013159106126177219275
po28581048013161118
léčbě850119801312476124182235
sunitibem11081198013148104160181213233292345434
v15651198013156
první1650119801316293145203223
linii,1896119801313050106127147163
další20881198013161108129167187
zajímavostí22971198013152101122142231279325381420454474
jsou2794119801313068125182
výrazné850134801314997127173214269318
regresivní1183134801313280136164212249267312368386
změny15841348013143129178232275
v18731348013149
primárnímnádoru1937134801315988107192237265320339423496541596651679734
ledviny2692134801311666122168187241284
po8501498013161118
cílené99114980131496991141197248
léčbě.1261149801312575122179231246
Parciální15301498013155101130174194240260315335
remise1887149801313383170189226277
onemocnění21871498013159115166253309356412462518537
trvala2746149801313665116164184230
sedmměsíců.850164801314192150237346397435454500555570
ZÁVĚR3205858018183179257334416
I33531198013123
přes3396119801316091142181
moderní35971198013189147206259289347369
cílenou398511980131497094146203261318
léčbu,4327119801311971119178235253
která4600119801314682132163212
vede48321198013149100160212
u50641198013157
řady5145119801312877136184
pacientů32031348013161111159181234292323381
k36081348013152
remisi3684134801313990179201240261
onemocnění,39691348013165123176265323373431484542563581
je4574134801312982
mRCC46861348013190145207265
závažné49751348013150101148198242301354
nevyléčitelné32031498013159112161213236289338360393444467524577
onemocnění.38031498013158117170259317367425477535557575
Cílená4400149801316385109162220269
léčba4693149801312174124183233
pacientů49481498013161111159181234292323381
výrazně32031648013149100131180223281332
prodlouží3554164801316091146205226283339382404
život3977164801314365113169200
se4196164801314092
zachováním4307164801314493141197254301349406426513
jeho4844164801311970127183
kvality.5047164801314597145167187220270282
LITERATURA:852208401475992157220291371428510580661689
1.850224601335674
Dabestani9552246013373125187243286322376436461
S,1439224601336285
Thorstenson15472246013362124184220264301355415458518579
A,2157224601336792
Lindblad2272224601336085145207269295348410
P,2705224601336676
et2804224601336399
al.2927224601336086108
Renal30592248013164117175223246
cell33292248013157108130152
carcinoma35052248013157107138185207264322412461
recurrences3990224801314092141199230262314372421471512
and45262248013158115175
metastases47332248013190143176226266300350390443483
in5240224801313188
primary850239801316193115204253284336
non‑metastatic12102398013159117176209300353386435475510559592614662
patients:18962398013161111143165217275307349366
a22872398013149
population‑based23612398013160119180238260309341363421479513574624663716777
study.3162239801314175133192241254
World34402398013190146178201260
J37242398013138
Urol37862398013169100156179
2016;3989239801315410615320041872398013120
34(8):4231239801315410713618721344422398013120
1081–1086.44862398013154101155203252298345399453472
2.850254601335679
Motzer9522546013389150185234289324
RJ,12992546013360103124
Bacik14462546013360113162187238
J,1707254601334062
Murphy17922546013388148184246307357
BA,21722546013360125150
Russo23452546013359119162204265
P,2633254601335868
Mazumdar27242546013388141188249340402454489
M.32362546013389113
Interferon‑alfa3373254801312381112163195227279310367425459508530558609
as4006254801314989
a41192548013150
comparative41932548013149105194254304335385417439489540
treatment4757254801313466117165198287340398430
for5211254801312886118
clinical85026980131497193150172220270292
trials116626980131346689137159198
of1388269801315887
new14992698013159112190
therapies1714269801313492145176226285308361401
against21392698013150109158180237277311
advanced24742698013150110159209267315366426
renal2925269801313284141190212
cell3162269801314999122144
carcinoma.3330269801314999130177198256314404453472
J38262698013138
Clin3888269801316384106163
Oncol40762698013173132181237260
2002;4360269801315410516021045712698013120
20(1):4615269801315410513418220248142698013120
289–296.48582698013154105157214261313367386
3.850284601335678
Fyfe9552846013353103139194
G,1175284601337195
Fisher1297284601335478120181236271
RI,1595284601335986109
Rosenberg17312846013359119162217278339395431492
SA,22492846013354120145
et2421284601335591
al.2535284601335782105
Results26682848013156109149205227261302
of2998284801315887
treatment3109284801313769121169201290344401433
of3570284801315887
25536812848013157110159
patients38672848013161111143165218276308349
with42442848013179102135193
metastatic44652848013190143176226266300350382404452
renal4941284801313688146194217
cell51822848013152103126147
carcinoma850299801314999130177199256314404453
who13262998013180138197
received1547299801313283133183205255306367
high‑dose1937299801315981140198231293351391444
recombinant2405299801313283133189278338361418467525557
interleukin-22986299801312280111162194217270327372396454487533
therapy.3543299801313492145176226286333347
J39142998013137
Clin3975299801316284106163
Oncol41622998013174132181237260
1995;444629980131539815220446462998013120
13(3):468929980131549812517520048872998013120
688–696.49302998013154108161218275326380399
4.850314601335679
Escudier955314601335498147207269294349384
B,1365314601336082
Eisen1474314601335478121176236
T,1737314601335470
Stadler1833314601335589142204229284320
WM,21793146013393180204
et2409314601335591
al.2527314601335378100
Sorafenib26523148013154112144194222274332354413
in3089314801312684
advanced31973148013153112162212269318369429
clear‑cell3650314801315274127175207235287337360382
renal‑cell4056314801313587145193216249300351373395
carcinoma.44753148013152102133180202259317407456475
N49773148013170
Engl50713148013155112171193
J52883148013141
Med8503298013186139199
2007;1073329801315410516021012753298013120
356(2):1319329801315410315518323526115773298013120
125–134.1621329801315498151206253297351369
5.850344601335677
Motzer9493446013388149185234288324
RJ,12943446013359103124
Rini1440344601335985145170
BI,1631344601336086109
Bukowski17623446013359120170229309352403429
RM,22133446013359148172
et2406344601335592
al.2519344601335378101
Sunitinib26423448013151108166187221243300322381
in3047344801312179
patients31483448013161111143165218275307349
with35193448013179102135193
metastatic37343448013191144177226266301350382405453
renal4211344801313082140189211
cell44443448013149100122144
carcinoma.4610344801314999130177199256315404453472
Jama5107344801313684173222
2006;850359801315410516021510633598013120
295(21):1107359801315410515718323428130114063598013120
2516–2524.14503598013154107153200257305358408455473
6.850374601335679
Motzer9573746013388149184233288324
RJ,13083746013359103124
Hutson14593746013372132168212273334
TE,18163746013359113136
Tomczak19753746013359112203252301356407
P,2409374601335868
et2504374601335592
al.2619374601335782105
Overall27523748013174125176208258280302
survival30783748013145101133186208258308330
and34323748013154112171
updated36313748013159118179228260311371
results4026374801313788128185207240282
for4332374801313390122
sunitinib44783748013145102160181215237294316375
compared48783748013153109198258308339391451
with8503898013179102135193
interferon1067389801312380112163195227279310367425
alfa1516389801314972100150
in1691389801312279
patients17943898013161111143165217275307349
with21663898013180102135193
metastatic23833898013190143176226266300350382404452
renal2859389801313284142190213
cell30953898013149100122144
carcinoma.3263389801314998130176198256314404452471
J37583898013138
Clin3819389801316385106164
Oncol40063898013174133182237261
2009;4290389801315410516021445023898013120
27(22):4545389801315410312717823125747993898013120
3584–3590.48433898013154103155211267316366414469486
7.850404601335668
Albiges942404601336793154180241296339
L,1305404601335276
Powles14054046013358116196222277320
T,1749404601335571
Staehler1844404601335488142196257283338373
M,22424046013388112
et2378404601335692
al.2494404601335379101
Updated26214048013169128188237269320380
European30274048013151106137194254308356414
Association34664048013165107146205254276324356378436495
of3986404801315887
Urology40984048013169100156179237297346
Guidelines44694048013169127149208261283305362415456
on49504048013158117
Renal50924048013156109167215238
Cell8504198013163114136158
Carcinoma:10314198013162112143190212269328417466483
Immune15384198013122111200257315368
Checkpoint19284198013163121174223269330389412469501
Inhibition2453419801312279137159218241274296354413
Is2890419801312160
the2975419801313290143
New31414198013170123202
Backbone33654198013156106154199261321379432
in3821419801312279
First‑line3923419801315172103144179208231253310364
Treatment4309419801315176127175208297350408440
of4771419801315987
Metastatic48814198013185139172221261296345377400448
Clear‑cell850434801316385137185217246297348370392
Renal12664348013156109167215238
Cell15284348013162113136158
Carcinoma.17104348013162112143190212270328417466485
Eur22194348013152107138
Urol23814348013169100156180
2019;2585434801315310515319827814348013120
76(2):28254348013154102130181207224
151–156.3073434801315398145194240285337356
8.850449601335680
Gong9544496013371132193255
J,1232449601334263
Maia13194496013389142167219
MC,15624496013389152177
Dizman1763449601337399145237289350
N,2137449601337295
Govindarajan22574496013371132183209269331384419472497550610
A,2892449601336792
Pal30084496013359110135
SK.31684496013354112138
Metastasis33324498013186139172222261296345385406445
in3801449801312582
renal3907449801313485143192214
cell41454498013151102124146
carcinoma:43154498013150100131178200257316405454471
Biology4812449801315577135158216276325
and51614498013151109168
implications8504648013123112171194216264314346368426484524
for1398464801312986118
therapy.1540464801313492145176226286333346
Asian19114648013164106127175233
Journal2168464801313896154186245293316
of2508464801315887
Urology2619464801316899156179237297346
2016;2989464801315310515319931874648013120
3(4):3231464801315480130155172
286–292.34274648013153104158216263315365383
9.850479601335675
Zhou9464796013360120180241
L,1207479601335275
Liu1303479601335177136
XD,14594796013363135154
Sun16344796013354113174
M,18284796013388112
et1960479601335592
al.2072479601335378101
Targeting2194479801315193124182235268290347407
MET26224798013185136189
and28324798013150108167
AXL30204798013164126174
overcomes32154798013158106158190236292382435475
resistance3714479801313081121143182216266323372423
to4161479801313187
sunitinib4272479801313894152174207229287308368
therapy4664479801313189142173223282330
in5018479801312077
renal5119479801312981139188210
cell8504948013149100123144
carcinoma.1018494801314999130177199256315404453472
Oncogene15144948013174133182238298351409462
2016;2000494801315310515319921984948013120
35(21):22424948013154103129180227248264
2687–2697.25304948013154105159209257305355407456463
10.8505096013356107129
Callea10015096013363116142167221274
M,12965096013389113
Albiges1430509601336893155180241296339
L,1791509601335275
Gupta18885096013371132193229283
M,21925096013389113
et2326509601335592
al.2439509601335379101
Differential2563509801317194123153205236288345377399448470
Expression30555098013151101161193244285324346404462
of3539509801315987
PD‑L136495098013155124159209254
between39255098013161115148230282335393
Primary4341509801315585108197246277329
and46925098013150108167
Metastatic48815098013186139172222262296346378400448
Sites850524801315172106156197
in1071524801312380
Clear‑Cell1175524801316385138186217246312363385407
Renal16065248013156109167215238
Cell18685248013162113136158
Carcinoma.20505248013163112144190212270328417466485
Cancer25605248013162112170218269301
Immunol28855248013123112201258316374397
Res33065248013156109149
2015;3479524801315410515319836735248013120
3(10):3717524801315480128175202218
1158–1164.3959524801315495140191248294334381437455
11.8505396013356101118
Faivre9885396013354102127180216270
S,1278539601335577
Delbaldo13755396013373129155217270295357417
C,1812539601336488
Vera19205396013361112148201
K,2141539601335985
et2246539601335592
al.2358539601335378100
Safety,24795398013151101129181214265278
pharmacokinetic,27785398013161119168199289338387443489513570623657679727745
and35445398013150108167
antitumor37325398013150108139161195253341400432
activity4184539801315099135157207229263314
of4519539801315887
SU11248,46265398013151117165206250298353371
a50185398013150
novel50895398013159117165217239
oral850554801315991140163
multitarget10375548013190147169202224258307339396449482
tyrosine1544554801313485117174214235293346
kinase1914554801314770128177216270
inhibitor,2208554801312380138160219242275331363376
in2608554801312381
patients27135548013161111143165217275307349
with30865548013179102135193
cancer.3303554801314999157205256288302
J36295548013138
Clin3691554801316385106164
Oncol38795548013173132181237260
2006;4163554801315410516021543765548013120
24(1):44205548013154101130178198215
25–35.46595548013153106162210260277
12.8505696013356104127
Najjar9975696013372125151179231266
YG,12835696013359126150
Mittal14535696013388114150188242267
K,1740569601335985
Elson1845569601335479121181242
P,2107569601335868
et2195569601335591
al.2306569601335378101
A24285698013164
225135698013153
weeks25875698013179131185231275
on28825698013159117
and30205698013149107167
132075698013154
week32815698013180132186231
off3533569801315887117
schedule3671569801314189147200260317340392
of4084569801315887
sunitinib4191569801314198155177210233290312371
is4586569801312059
associated4665569801315090130188237259307339390451
with51365698013179102135193
decreased8505848013160113162194245293333386446
toxicity1320584801313490136158207228262313
in1657584801312381
metastatic17625848013190143176226266300350382404452
renal2238584801313384142191213
cell24755848013149100123144
carcinoma.2643584801315099131177199257315404453472
Eur31405848013151106137
J33015848013138
Cancer33635848013163113171219270302
2014;3689584801315310515319938865848013120
50(6):39305848013154105134184211227
1084–1089.41825848013153100154210266313360414465481
13.8505996013356105126
Staehler1000599601335994147202263288343379
M,14085996013388112
Haseke15495996013372125167222274327
N,1905599601337295
Zilinberg2029599601336186111136196258314349410
E,2462599601336083
et2568599601336197
al.2688599601335984107
Complete28255998013163119208268291344377428
remission3277599801313890179201240279301358417
achieved37185998013156104162184236285337397
with41455998013179102135193
angiogenic43625998013156114173195253313366424446494
therapy4880599801314098151182232292339
in5243599801312986
metastatic8506148013190143176226266300350382404452
renal1326614801313384142191213
cell15636148013149100123145
carcinoma1732614801314998130176198256314404453
including2209614801312380129151208267289347406
surgical2639614801314198129187209257307329
intervention.2992614801312380112163195248299357389411469527546
Urol35626148013169100157180
Oncol37666148013174132181237260
2010;4050614801315410515320042506148013120
28(2):42946148013154105133184210227
139–144.4545614801315498148205252298355372
14.8506296013356106128
Mejean9976296013389144170224277337
A,1353629601336892
Ravaud14656296013359112162215274336
A,1820629601336892
Thezenas19326296013354116171218272333385427
S,2379629601335476
et2475629601335591
al.2586629601335378100
Sunitinib27076298013151107165187220242299321380
Alone3107629801316587145203256
or3383629801315990
after3494629801314977115166197
Nephrectomy37116298013170123183241272323373409465554600
in4335629801311977
Metastatic44326298013185138171221260295344376398446
Renal‑Cell48996298013155108166214236270335386408430
Carcinoma.8506448013163112144190212270328418467486
N13606448013170
Engl14546448013151109168190
J16686448013138
Med17306448013186139199
2018;1953644801315410615320021526448013120
379(5):21966448013154102152180231258275
417–427.2495644801315399142191247296346353
15.8506596013356105126
Bex9956596013360115166
A,1181659601336792
Mulders12926596013388148174235290325369
P,1681659601335868
Jewett1768659601334196176230266304
M,20926596013388112
et2223659601335592
al.2334659601335378101
Comparison24566598013163119208267317348371409467526
of3002659801315887
Immediate31136598013119108196249309331379411462
vs3595659801315090
Deferred37056598013171125153205236268320380
Cytoreductive41056598013162104141197228280340397445481503552604
Nephrectomy47296598013170123183241272323373409465554600
in850674801312381
Patients9556748013156104136158211268300342
With13226748013190114147205
Synchronous1552674801315196155203261292349407465523563
Metastatic21406748013185138171221261295345377399447
Renal26126748013156109167216238
Cell28756748013163114136158
Carcinoma30586748013162112143190212270328417466
Receiving35496748013156109158209231280303361420
Sunitinib:39946748013151108165187221243300322381399
The44186748013151111164
SURTIME46076748013151117171223247331381
Rando‑50136748013156106163223281316
mized8506898013190112156207267
Clinical1142689801316284106163185233283305
Trial.147168980131517699147169187
JAMA1682689801313899185249
Oncol19556898013174132181237260
2019;2239689801315410515319824356898013120
5(2):2479689801315479131157173
164–170.26776898013153100155212259302352370
16.8507046013356107130
Dabestani10087046013373126188243286323376437462
S,1493704601335982
Marconi16037046013389142177225284345370
L,1996704601335781
Hofmann21057046013372133164257309369430
F,2558704601335971
et2652704601336197
al.2772704601335984106
Local29037048013155112161211233
treatments3160704801314071123171203292346404435477
for3661704801313492124
metastases38147048013190143177226266300350390443483
of4321704801316493
renal4438704801313889147196218
cell46807048013155106128150
carcinoma:48547048013155104136182204262320409458476
a8507198013150
systematic924719801314190131165216305354386409457
review.1405719801313284133155208286301
Lancet17307198013150100158207258291
Oncol20457198013174133181237260
2014;2329719801315410615320025277198013120
15(12):2571719801315498124172216242259
e549–561.28547198013153106159209266318370415427