612
435610226014562119
ORIGINÁLNÍ3862207016996181224324367468561635735777
PRÁCE4677207016983165262348424
Ces38137936014570127174
Urol40127936014578115180208
2020;42457936014562121178237261
24(1):45327936014561118151206230252
42–5048097936014562118175234293
na624898013158107
orgán75289801315890148197254
(bez103189801312586139184
extrakapsulárního1236898013153101137169219265315375415471494542574632654714772
šíření,20338980131375994145203225243
bez2297898013160114159
invaze248089801312077124174219270
semenných624104801314195184238296355401449508
váčků,11541048013149100149195253272
N0),14481048013170124152168
velikost16381048013150102126148194251292327
nádoru19871048013159108168227260319
≤23281048013165
0,52415104801315371125
cm3256110480131491392698105407631
.27311048013119
Výsledky:7741196013361112154178232293342396418
Celková12091198013163112134177233279328
incidence1560119801311874121142199251308355404
IKP1987119801311871125
v21301198013150
souboru2198119801314198154212270301358
byla25741198013160106128175
24,46241348013154102119172
%.8261348013183103
Při952134801316393115
zpracování10911348013152113145195243299347397455476
metodou15981348013192145178234294352410
WMS20391348013192176226
43,822891348013162111127182
%,25021348013183101
při2634134801316293115
zpracování6241498013144104135183231286333382438459
metodou11111498013190142174229288345402
bloků1540149801316183140185242
pouze18101498013160118175218269
2,42102149801315875126
%.22561498013181100
IKP2379149801312881136
loka‑2538149801312885130180212
lizovaných62416480131244488144192242299345392450
na10971648013167115
prostatu1243164801316193149189223272304361
bylo16351648013161108131189
95,518471648013162113128181
%,20591648013182101
GS21901648013170119
≤23401648013166
624321648013164
mělo25261648013191144166224
72,76241798013155109127181
%8421798013183
pacientů.9501798013175127177199253313346405423
Průměrný13981798013169100160252306338399446
objem18691798013173135158212304
nádoru21981798013173124185245278338
činil2560179801316386145167190
1,90624194801315464113166
±8141948013166
3,50904194801315369121172
cm3109319480131491371227195407631
.12581948013119
Jako1300194801313986131186
nesignifikantních15101948013159111150171229285306331357401451508538595616663719
IKP2252194801312577132
bylo24081948013161107129186
vy‑26181948013149100132
hodnoceno6242098013160118178236294343394452510
deset11582098013168120160213246
nádorů14272098013167116175233265323
(45,51774209801313686135150204
%).20082098013182107122
Statisticky2153209801315990139171193231266287335380432
vý‑26082098013158110142
znamný6242248013144101148234290334
rozdíl981224801312781122178198221
mezi12192248013189141183204
signifikantním/nesignifikantním14412248013141601171731932172442873363924224784985856226757267657848428979179429681011106011161146120212221309
IKP624239801312376131
byl7742398013160106129
pouze9222398013161119175219269
u12102398013158
objemu12882398013158117139190278334
nádoru,16412398013159107165222253310327
3,401987239801315470121175
±21812398013166
4,252266239801315369123175
cm3245823980131491372591240407631
vs.2646239801314685104
0,10624254801315470115161
±8052548013166
0,10890254801315470116162
cm3106925480131491371202255407631
(p1245254801312988
=13532548013166
0,021).1439254801315370122171217236250
Významný17092548013156104149207255343399444
byl21732548013161107129
také2325254801313179124174
rozdíl2522254801313085126183204227
mezi6242698013191144188211
GS8652698013170120
≤10152698013167
611082698013163
vs.1195269801315797116
GS13422698013169119
>14922698013166
715822698013162
a16672698013158
signifikantností1748269801314970129187208233260305355413444503561600635656
nádoru24282698013167115174232264322
(p624284801312988
=7382848013165
0,012)828284801315470123169213238
a10892848013152
mezi11662848013190142186207
počtem13982848013161119167202252340
nádorů17632848013159107165222253310
≤20982848013166
0,52189284801315874126
cm3233328480131491372466285407631
a25212848013152
sig‑2596284801314364122154
nifikantností624299801315980104131175225281312369426465499520
nádoru,11722998013159107165222253310327
315222998013160
vs.1605299801315595113
1017412998013160106
nádorů18762998013159106165222252309
(p2208299801313595
=23312998013166
0,0000).2420299801316076128182236290316330
Medián6243148013185137195216262318
doby9603148013160116175220
sledování1198314801314161112171227274322378398
byl16143148013160106128
19,5měsíců,1760314801315396109161268319358377424479496
u22733148013158
nikoho2349314801315979122178235291
se2658314801314192
IKP624329801312374127
klinicky76832980131466887142162207250299
neprojevil10843298013158108165195249269319365386406
a15073298013149
nebylo15723298013158109166210231287
potřeba18753298013160116147176225282329
zahájit2221329801314391147193213233264
léčbu.2507329801311767114171226243
Závěr:7743446013361113162214249271
V10613448013156
souboru1133344801314196152209266295351
jsme1506344801311754140191
prokázali1713344801316090144188236278326346365
vliv209434480131507190137
použitéme‑22463448013161118173215235266314420471503
tody624359801313487144189
na8293598013158104
přípravu948359801316089109166195242287342
histologického1305359801315978114146199219274331351396438487542597
preparátu.1918359801316089138194241270317346401417
Při2350359801315583102
použití24683598013160116171212232263282
WMS6243748013190172220
techniky866374801313180127183238258301350
byl12363748013161106127
záchyt1382374801314593140195239274
IKP1678374801312173126
výrazně18243748013150100130178220277328
vyšší.21713748013150100138175194210
KLÍČOVÁ6254034014770132164236320392464
SLOVA11164034014762123207279351
Incidentální,624419801312381130152212265323355405427485507525
karcinom11734198013155106138185207265323413
prostaty,16114198013169101158198233283315367380
karcinom20154198013155106137184206264323413
močo‑24604198013191149199255290
vého6244348013150102160218
měchýře,8664348013190143192250296329380397
signifikantní.1287434801314162121179201227253298349407438497518537
SUMMARY6254634014762143243345423493561
Šamal7744798013152104195245269
V,1068479801316578
Richter1171479801316588138198231283316
I,1512479801313251
Paldus15884798013165115138199258298
V,1911479801316678
Jirásek2014479801314870103154195250297
T,2336479801316173
Mečl24434798013187142193216
J.2684479801314766
Incidence624494801312381130151210263321370421
of1071494801315987
prostate1185494801316092149189223273305356
cancer15654948013152101159208259290
in1879494801312683
radical1986494801313585145166215264287
cystopros‑22974948013151102143177233293325382422453
tatectomy624509801313483115165214250306395441
specimen.10845098013141100154203224312365422441
Histopathological1545509801316990129163219279328360417475498555615637685734756
character‑23215098013149106154185235283319369400429
istics62452480131236297119167209
of857524801316795
tumor977524801314299189247279
and12805248013158116176
the14805248013142100154
influence1658524801313189114141198251309358409
of2091524801316795
the22105248013142101154
method23965248013190143177235293354
of624539801315989
histological738539801316890130166223247307368391440491514
processing12775398013170103161212264305346368427488
on17905398013167127
the19425398013143103157
occurrence21245398013168118166225257290343402452504
of2653539801316897
incidental624554801312381129151210263321353402424
prostate1073554801316092149189223273305356
cancer.1453554801314999157205256288302
Aim:774569601336893184205
Radical10025698013166118179203253305329
cystoprostatectomy13575698013159112155191249312346405447483535569622673712770862910
(RCP)2293569801313996160216243
as25625698013160102
a26905698013160
surgical624584801314199132192215265316340
procedure9905848013170103162213265327386419472
in1488584801313291
the16055848013143103158
treatment1788584801314477130180213305360419452
of2266584801316898
invasive2390584801313291140192233256306360
bladder624599801316185135195256310342
cancer9895998013149100159208260293
requires1307599801313083144202225257310351
a16815998013150
high1753599801315982142201
degree19775998013160114175207260315
of2315599801315888
radical‑2428599801313081141164214264288322
ity.624614801312460114130
Surgical7816148013162122156217241293346370
techniques1178614801314599152213274298360421477520
sparing17256148013152114168202227288350
prostate21026148013172107167210247300335389
apex25186148013161124181232
or624629801315992
capsule7416298013159110171212270293348
involve1114629801313291140198222273326
the14656298013144103157
risk1648629801314265106152
of1825629801316898
residual1948629801314295136159220278328352
urothelial23256298013168100158192251306330352402425
carcinoma624644801314999131178200258317407456
or1102644801315891
incidental1218644801312078127150209262321353403426
prostate1666644801316093150191226276309360
cancer2048644801314999157206258290
(IKP).2362644801312749103159186201
The25856448013151112165
aim624659801315072161
of806659801315887
this918659801313189111151
work10916598013178136168215
is1331659801312059
to1415659801313187
assess1524659801314989130183224264
the1812659801313190143
occurrence,19776598013158108154212244277329387436487504
histo‑2503659801315981120155211247
pathological6246748013161112145204264288347408431480531555
characteristics12046748013153112162194245295332384417441481516539589632
of1861674801316392
IKP1978674801312882140
and21436748013154113173
the2342674801313897151
influ‑2518674801312886113140198232
ence6246898013153112162214
of863689801316898
the9866898013143102156
method11776898013190144178237297358
of1561689801316797
histological1683689801316891131167224248307369392441492515
preparation22236898013170103156217268300351385408467527
processing624704801316194151202254295336359417478
on11287048013159118
the1271704801313595149
occurrence14467048013159109157215248281334393442494
of1967704801315888
IKP.2080704801312479136142
Material7747196013388140175227262286337361
and11597196013353112173
methods:13557196013391145181240299360402423
A18017198013164
group1889719801316090146203261
of2174719801315886
9122847198013153100
patients24087198013161110141162213270301341
after624734801314975110158187
RCPwere8287348013154114164259308337386
evaluated1231734801315298145166220266296344401
retrospectively,1654734801312776106136190227283335382415435482531551597608
with2278734801317899130185
proce‑2479734801316090144190239271
dures6247498013159114144193231
performed8727498013160112142172227257345396454
from1348749801312455109196
January1562749801313784139194241270320
200918997498013153103156207
to2128749801312983
August22287498013163118175230267300
2019.25457498013153103148191205
In624764801312481
427297648013161110
patients8637648013169118150172224282314355
the1242764801314199152
prostate14187648013169100157196231280312363
was18127648013180130169
evaluated20057648013161109159181238286318369429
by24587648013169116
the25977648013142100153
block297689801316082138186230
method,3224898013189141172229285344360
in360789801311874
493699898013153101
patients3818898013160109139160211267297338
the417889801312985137
whole-mount4333898013179135192214265298386443499556586
sec‑493789801314092140165
tion2976104801313353109165
(WMS).31631048013123112193240266279
The34591048013151108158
work36341048013178133163207
assessed3857104801315087124175213250301359
the4238104801312883134
histopathological4389104801315877114146200257305335390446467522580600646693713
characteristics29761198013149106153183232280315365395417454488509556597
of3595119801315885
IKP.3703119801312375130134
Criteria3859119801316393114147196227248295
for4177119801312884115
non-significant43141198013159116174206245265323380400425452499548605635
IKP4972119801312275130
determination:29761348013161115148200232323345404453486508566626643
Gleason3650134801317194148196237296355
score4029134801315099156188241
≤43011348013167
6,4393134801316280
organ-limited44971348013168100159208267301325346436458492544605
disease2976149801316284123178227267321
(no3322149801313793153
extracapsular34991498013163112149181232282332393434492514564596
extension,41191498013162111148200260300321380440458
no46021498013168127
seminal47541498013150104195217276326348
vesicle29761648013150100140160207228280
invasion,3279164801312278124173211232288346363
NO),36631648013171143168183
tumor3868164801313390178235266
size4157164801314060103153
≤43321648013166
0.54420164801315370122
cm3456416480131491374699165407631
.47301648013119
Results:31261796013359113155213238272315336
One34941798013174134188
patient37071798013170121154177231290323
was40631798013180131172
excluded42601798013162111159182240300354416
from4701179801313872129220
the49461798013143102156
evaluation.29761948013155107161186247299334359421483505
The35081948013166130187
overall37221948013173125181215269294318
incidence4067194801313899151176239296357410464
of45581948013174105
IKP4690194801313895155
was49101948013195149192
24.4%.29762098013155106126181263286
With32982098013193119155216
the35412098013144106162
WMS37392098013193181234
processing39992098013172107167220274317359383444507
method45422098013192149184246307371
the49402098013144106162
incidence2976224801312384135158220275336387440
was34522248013181133175
43.836532248013164116135192
%,38812248013182104
while40202248013181142166190245
with43012248013180105141201
the45282248013144105161
process‑47152248013171105164216269312354387
ing2976239801312382142
blocks3144239801317094153204250295
method34742398013190144178238297359
it3858239801313267
was39592398013180131171
only41562398013167127151200
2.44381239801316382135
%.45512398013181102
Localized46792398013158116167218241264309361423
IKP2976254801312378135
was31412548013179130171
95.533372548013159112129184
%,35512548013181102
72.736782548013158112130183
%38912548013181
of3997254801316493
cases41162548013153104145199241
had43822548013164113174
GS45862548013169120
≤47362548013166
6.4827254801315879
The49312548013156117171
average2976269801315099152184235296350
tumor3351269801313796186245279
volume36552698013153111135193283338
was40212698013180130171
1.904217269801315771122178
±44242698013165
3.504514269801315776131184
cm3472326980131521424865270407631
.48972698013119
Ten49412698013155102161
tumors2976284801313491180238271312
(45.53312284801312676126143197
%)35302848013181106
were36582848013178130162214
evaluated38932848013153102152175232281313364425
as4339284801315090
non-significant44502848013158117175209250272331389411437464512562620652
IKP.2976299801312480139146
Statistically3149299801316195147182206247284309360412437460511
significant3686299801315275137198222250277329381442476
difference4188299801317195127157212246300361412466
between46802998013172129164249304361422
significant2976314801314164125185208235262312364423457
/34593148013148
non-significant35323148013169129189225267289350410433461487538589649682
IKP4240314801313288146
was44213148013180131173
only46193148013168129152202
in4847314801313292
tu‑49643148013144103138
mor29763298013190150183
volume,31843298013159117141199289343361
3.403570329801316382135191
±37863298013175
4.253886329801316281137191
cm3410232980131581494250330407631
vs43063298013159100
0.104432329801316281128177
±46343298013174
0.10cm347333298013163821291772293195051330407631
,50833298013119
p29763448013161
=30653448013165
0.021.3155344801315776130181229242
There34223448013154115169202255
was37043448013180131171
also3901344801315276115175
a41013448013153
significant4179344801314366126185208235261311362421453
difference4660344801316083113143196229281340390442
between29763598013160115148230283337395
GS33933598013168119
≤35343598013165
636213598013153
vs,3696359801314990109
GS>38273598013169119181
740303598013153
and41053598013150108168
tumor4297359801313189178237270
significance4591359801313860120178200227253302352410459511
(p2976374801312991
=30913748013165
0.012)3181374801315372127175221248
and34543748013150108169
between36473748013161116150233286341400
number40723748013158117207267322355
of4451374801315988
tumors4565374801313391181241274316
with49053748013180103138197
volume29763898013149107131188277331
≤33293898013165
0.53416389801315472126
cm3356438980131491393702390407631
and37583898013147105165
tumor3948389801313189178237270
significance,4243389801313860119178200227253302352411460511529
347943898013153
vs.4869389801315091111
1050023898013153101
tumors2976404801313493183242275317
(p3319404801313495
=34444048013166
0.0000).3535404801315978132188244300328345
The39054048013156117171
median41064048013190145206229278337
follow-up4468404801313492116139198278312372433
was49314048013179130171
19.52976419801315499116170
months,31684198013190150209242301341360
with35514198013179103137196
no37694198013159118
clinical390941980131497295153176225276299
manifestation42304198013190140199221250303345380431464487545605
of4857419801315888
IKP4970419801312075132
and29764348013150109169
no31724348013159118
need33164348013159113168230
to3571434801313592
start3688434801314278129161199
treatment.3912434801313568121170203294348407440460
Conclusion:31264496013363119177224247304344367424483502
In3651449801311977
our37494498013157115146
cohort39164498013149104163220252289
the4250449801313088141
method44124498013189141175232290350
used4783449801315897150209
to5017449801313086
prepare2976464801316194146207258291343
a33434648013150
histological3417464801315982122157215239298359382432482506
specimen39484648013140100155206228318373432
has44034648013159109150
a45774648013150
significant4652464801314062123181204231258307358417450
effect.2976479801315383112165215252272
Using32704798013169108130188248
the3543479801313190144
WMS37094798013190174225
technique,3959479801313182133191249272331389443460
the4444479801313190144
IKP4613479801312074131
capture47664798013149100160193252284336
was29764948013179130171
significantly3172494801314265125184207234260310361419452476525
higher.3723494801315982142201255287303
KEY29785234014770134206
WORDS321152340147105189260345408
Incidental,2976539801312483134157218272332365417440459
prostate34605398013170104162204240291325377
cancer,38635398013158110170220273305319
bladder4208539801317095145206268323355
cancer,45895398013158110170220273305319
sig‑4934539801315073134168
nificant.2976554801315981107133182231289321340
………297658340147120240360
ÚVOD29786258018197183286388
Radikální31266598013156108169193240293317376399
cystoprostatektomie35516598013159112154191249311345403445482533567620668706764857880935
je4511659801313388
stále4625659801315187139162217
stan‑4868659801315187139199234
dardem29766748013160110142201255345
léčby3346674801312276126187235
invazivního3606674801312280129180225249299359382443503
karcinomu4134674801314597129177200258318409467
močového46246748013191150200257307360419478
měchýře29766898013190144195253301334387
(KM)3388689801313791180207
a36206898013158
recidivujícího3704689801314093143166226249300359382405454477538598
povrchového43276898013168129178212259318378427480539599
KM49516898013163151
v29767048013150
případech,3054704801316194117178229289343394453472
že35517048013148100
selhává3676704801314498122181231279330
adjuvantní40317048013153114137195246297355388448470
intravezikální4527704801312684117150201250303348372418470494552575
léčba.2976719801312375124183232251
Karcinom32487198013154104135182203260318406
prostaty3675719801316092148187221271303353
(KP)4052719801312678134160
je4236719801312072
nejčastější43297198013157110132180229268302353374413434
maligní47847198013189137159181239296318
nádor29767348013159109169229262
u32637348013163
mužů33567348013190148194252
v36347348013154
ČR,37187348013163118139
jeho3882734801312982142201
incidence4108734801312887136159219273332382434
stoupá.4567734801314682139198259310330
Pre‑4922734801316092144180
valence29767498013150101124178237287339
latentního3340749801313180114166225258317340401460
KP38267498013162119
je3970749801313285
ještě4080749801313285127162214
vyšší,43197498013157111152193215234
než45787498013167121167
klinicky4770749801315479102161183233279332
diagnostikované2976764801316083132193251311352388411457515564615674728
případy3731764801316093117177228289338
(1).4094764801313179101117