538
1895582226014562116175
PŘEHLEDOVÝ3675207016974156235334409485586692777867
ČLÁNEK4580207016989163260360438521
Ces36947936014570127174
Urol38937936014578115180208
2020;41267936014562121178237261
24(3):44137936014561118151209238260
183–19046997936014561116175235288341403
určení62489801315993142196256281
podílu931898013172134197221248308
jednotlivých126689801313489152213274309334358410465515576
podtypů1869898013171133196233287350411
renálního230789801314397158209234295319382443
karcinomu624104801314697129176199257315404462
je1111104801312174
velmi12071048013149101125213236
obtížné,14661048013157117151174218277331348
jelikož184010480131207397119165222265
nově21281048013158116165217
popsané23681048013159119179220271329382
jednotky624119801312479142202263298346400
se10511198013151107
nepromítnou11841198013170126188222281374398434495556616
statisticky1827119801315188140175199241278302353401455
do23091198013170131
počtu24661198013172133185224284
celosvětově6241348013149103128188231284338373432482537
diagnostikovaných1187134801317095145207268329371408433480540590643703752802862
nádorů20751348013170121183244278339
ledvin,2440134801313489152204229290310
respektive624149801313286129190246294333357409463
se1113149801314399
promítnou1240149801316195154246270305366426486
s17521498013144
velkým18221498013152106131178232324
zpožděním.21721498013147110171216276331391415506527
Je774164801313792
rovněž891164801313088137197251296
zřejmé,1213164801314275127151240294313
že1551164801314294
dělení16691648013159113137190249272
renálních1967164801313083141191215273296345404
karcino‑2397164801314496128176199258317353
mů6241798013190149
na8001798013159110
světlobuněčné936179801314194147182207267330390450505556616672
a16341798013150
na17101798013159110
ostatní18471798013158100137189223284308
(označované2181179801312986130191242293351401453513569
zejména624194801314498122213269329380
ve10301948013160114
studiích1170194801315188148209233257307367
s15641948013151
metastatickým16511948013190146181233275311363398422472520574666
renálním2343194801314397157208232292316407
karcinomem6242098013148104140192218281345441500595
jako1248209801314598149211
„nesvětlobuněčné14882098013153118177222277334372399462528592655713768831890
renální24062098013154111174228255318344
karcinomy”)6242248013147102137187212273335429479517552
(Non‑Clear12032248013140113175237274344369425477512
Cell17422248013174129155180
RCC)19492248013167133195229
nemůže22052248013171127221282329384
do26162248013172134
budoucna2976898013161121183243304354415466
obstát.3468898013169131174210262297318
Pokud3812898013166124172232294
je413389801313388
snahou4247898013152111162223283343
nabídnout4617898013169120182207268328389449485
pacientovi29761048013161113164188242302336395445470
skutečně3472104801315097157193246298358413
cílenou3911104801315781108163223284344
onkologickou42811048013167128175234260320382406457504563623
léč‑4931104801313186138171
bu,29761198013161121141
bude31461198013161121183238
nutné34131198013159118154214270
renální3709119801313589149200224284308
nádory40461198013158109171231266320
detailně43951198013159115150202226250309364
popsat47881198013161123185227280314
a29761348013150
precizně3050134801316195148200224269330385
klasifikovat.3461134801314571122163187217242290348398450484506
Cesta39911348013163116158194246
k42631348013145
personalizované‑43321348013161117150193253314365389412458517567619678733770
mu29761498013190149
přístupu31521498013169103127168205265327387
bude35651498013169130191247
ale3838149801315882137
ještě4002149801313186129165218
dlouhá4246149801316893153213273324
a45961498013159
v46811498013158
nejbliž‑47651498013167122147208234257303337
ších2976164801314165115176
letech3178164801313489125178230290
asi34951648013160102126
ještě3647164801313489132169222
není38951648013170125186210
zcela41311648013155104158183234
reálná.4391164801314397148172232283305
Limitují‑4722164801316085176200236296321345380
cí2976179801314974
je3076179801313489
nízké3192179801317094140189243
zastoupení34621798013155108150188246307369426486511
vzácnějších39991798013160110163214275331355396420471531
lézí4557179801313489136161
s47451798013152
téměř4823179801314598190246279
nemožností29761948013160117211274320383445489527552
organizovat35561948013170106168221282307355416468522557
kvalitní41411948013158115168194219256318343
prospektivní45111948013173109169213276334384424450503566591
randomizované2976209801313285145206266358382428487537590649705
studie,3707209801314178138199223278297
omezená40302098013159151206253307367418
škála4474209801314188141166217
léčiv4717209801312378130153205
pro4948209801316195154
systémovou2976224801314192135172225316377427487547
terapii.3549224801313689123175237262286306
LITERATURA625268401475992157220291371428510580661
1.624284601335673
Hora7212846013372132168221
M,9652846013389113
Hes11012846013372127170
O.1294284601337696
Histologie1414284801316991130165221244302362384436
nádorů18752848013158107167225257315
ledvin2214284801312376136186209266
dospělých.25042848013160118158217271294341389447466
Ces29942848013162113154
Urol3172284801316999156179
1998;3375284801315499152205223
2:3622284801315371
29–32.37172848013154105163211260278
2.624299601335679
Hora7242996013372133168221
M,9662996013389113
Ürge11002996013371106166221
T,1342299601335571
Kalusová14342996013359113138198241301353405
K,1860299601336085
et1966299601335592
al.2079299601335378101
Novelizovaná22002998013170129177229251273317373421471529578
klasifikace2799299801314771120159181207233278329378429
nádorů32492998013159108167225257315
ledvin3589299801312073133183206263
201338742998013153105153197
(International4095299801312749106138189221279328360382440499547570
society4689299801313896146168220253305
of5015299801315987
urological624314801315890146169227288309358407430
pathology10783148013160110143201259282340400449
vancouver1551314801314999157206262320369421452
classification2027314801314971120160200221247273322372404426484542
of2593314801315987
renal2704314801313384142191213
neoplasia).29413148013159112171231255303343364412438453
Ces34183148013163114154
Urol35963148013169100157180
2014;38003148013154105153199216
18:40403148013154100117
9–20.41823148013153110158209227
3.624329601335678
Moch7253296013389149199259
H,1007329601337295
Humphrey11253296013372132223285346381436486
PA,16353296013358118143
Ulbright1801329601337197158194220281341376
TM,22003296013355142166
VE23893296013362116
R.2528329601336085
WHO26363298013190159233
Classification2893329801316284133173212234260286335385417439496555
of3472329801315887
Tumours35833298013151101190248306337378
of3985329801315987
the4096329801313492145
Urinary42653298013169100122180229260312
System4601329801315195136170221310
and49353298013150108167
Organs.6243448013174106164213271310330
IARC978344801312385140202
Lyon1204344801314992149207
2016.14353448013154106153200219
4.624359601335679
Ljungberg726359601335278137198259321377412473
BAL,12233596013359125176199
Bensalah14463596013359115176218271297349409
K,1879359601336085
Bex19883596013359115166
(Vice‑chair)2177359601333296122171224260312372424449485513
A,2714359601336792
et2829359601335592
al.2944359601335379101
EAU30693598013151117181
guidelines32743598013160117139198251274295353406446
on37443598013159117
renal3886359801313284142190213
cell41233598013149100122144
carcinoma.4291359801315099131177199257315404453472
https://4788359801315990127187227245285315
uroweb.org/guideline/renal‑cell‑carcinoma/,6243748013158901462242773363544124445025415956526747337868088308879409801008106011181166118912221273132413461368140114521502153315801602165917181807185618961903
ISBN2552374801312371124194
978-94-92671-07-327703748013154103154188240295329382432483532581609665714741790
2020.35743748013153105155206224
5.624389601335676
Kolář7213896013360117142194228
J,971389601333960
Pitra1052389601335881116150202
T,1275389601335570
Pivovarčíková1366389601335881133190241292327374397449507557609
K,1996389601335984
et2101389601335590
al.221338960133537798
Hereditární23333898013169121152202261282314363393451471
renální2827389801313182139186207264284
nádorové31333898013159107165222253309356406
syndromy.3562389801314089147205235290379424436
Ces40203898013163113152
Urol4194389801316999154176
2020;43923898013154104153203220
24:46343898013154100116
26–41.47723898013154104160215260271
6.624404601335679
Guo7324046013371132192
J,948404601334667
Tretiakova1039404601336089143180204257308366418470
MS,15384046013389142165
Troxell1726404601336089149198251277302
ML,20574046013389141164
et2244404601336198
al.2365404601335984107
Tuberous24954048013157107167221252309367406
sclerosis‑associated2925404801314796118171202259299320359390439478518576626648696728779839
renal3788404801313990148197219
cell40314048013155106129150
carcinoma:42054048013155105136183205262321410459476
a47064048013155
clinico‑478640480131547798156177226282316
pathologic6244198013161111143201259282340400422471
study1119419801314175133192241
of1384419801315887
5714954198013153104
separate1623419801314194154204235285317368
carcinomas2015419801314999130177199256314404453493
in2532419801312380
1826364198013154100
patients.27604198013161111143165218276308349369
Am31534198013164153
J33314198013138
Surg33934198013151107139197
Path36144198013155103135193
2014;38314198013154105153200216
38;40714198013154106123
1457–1467.42184198013154100150200249295341396446453
7.624434601335668
Yang7174346013360107167228
P,971434601335868
Cornejo10644346013364123159220275300360
KM,14504346013359150174
Sadow16494346013354108169230309
PM,19844346013358144168
et2178434601335591
al.2294434601335379101
Renal24214348013156109167215238
cell26834348013151102124146
carcinoma28534348013151101132179201258317406455
in3332434801312583
tuberous3439434801313694154208239295353393
sclerosis3856434801314392114167198255295316355
complex.42354348013151107197256279332380400
Am46614348013165154
J48394348013140
Surg49034348013153110141199
Path6244498013155103135193
2014;8424498013153105153199216
38:10824498013153105123
895–909.12294498013154106157212265319373388
8.624464601335678
Trpkov720464601335481141191247297
K,1035464601335983
Hes11364646013371125165
O,1320464601337593
Bonert14314646013360118177230263300
M,17494646013389110
et1877464601335690
al.198546460133537696
Eosinophilic,21004648013151106144163218274332389408428447493510
solid,2628464801314197118138195210
and28574648013150106163
cystic3039464801314998136168188234
renal3295464801313079135181201
cell3515464801314998118138
carcinoma:3672464801314996125170190245301388435450
clinicopathologic414146480131496988144163209263321369399454510531587645665711
study4871464801314173129186232
of624479801315985
16728479801315499
unique,8464798013159114134190245296311
sporadic1176479801314198155185233290310356
neoplasms15524798013158109166224245291329415453
occurring20244798013159106150206235265285340398
in2444479801312076
women.25394798013180135222273329346
Am29044798013165152
J30784798013135
Surg31334798013151106135190
Path33434798013155101131187
2016;35504798013153103148193208
40:37774798013154107123
60–71.39204798013153105161206253263
9.624494601335675
Palsgrove7274946013358110135178239274334385439
DN,11934946013373146169
Li1385494601335681
Y,1494494601335974
Pratilas1595494601335993146181206231284326
CA,19494946013363132156
et2133494601335591
al.2248494601335782105
Eosinophilic23764948013156112152174231289350408430452473522
solid29224948013145103126148207
and31534948013154112171
cystic33484948013154104145180202250
(ESC)3622494801313383134196227
renal3873494801313688146194217
cell41144948013153104126148
carcinomas42864948013153103134181203260319408457497
harbor48114948013159108139200259291
TSC6245098013151102164
mutations:8195098013190147180230262284342401440458
molecular13075098013190149172225274331354402433
analysis17655098013156114163185233273295334
supports21235098013147104163224283315352394
an25415098013156114
expanding26795098013160108168218276335357414474
clinicopathologic317750980131557899157178227283343393425483541564622683704753
spectrum.39545098013147106161210246278336425444
Am44295098013164153
J46065098013145
Surg46755098013158114146204
Path49035098013161110142200
2018;6245248013154105153199217
42:8655248013153102120
1166–1181.1009524801315494141195253299340386434447
10.6245396013356107129
Hes7765396013372127170
H,969539601337295
Trpkov1087539601335483146198256308
K,1418539601335985
Martinek15265396013388141176216240301356407
P,1956539601335968
et2047539601335592
al.2162539601335378100
„High‑grade22865398013132102124183241274336367417477529
oncocytic28395398013159117166222271322360382430
renal3293539801313284142190212
tumor“:3530539801313391180238270304319
morphologic,38725398013190149181241300358381439500521570588
immunohisto‑44845398013123112200258315374432454493527583618
chemical,6245548013149107160249271319369391408
and10575548013150108167
molecular12495548013190148171224274331353402433
genetic17075548013159112170223256278327
study2058554801314176134193241
of2324554801315987
1424365548013153100
cases.2560554801314999139192232252
Virchows2836554801315680112158216274353393
Arch.:3254554801316496142200219237
an35165548013150108
international3648554801312381113164195254303335357414473522544
journal4216554801312482140171230279301
of4542554801315887
pathology46535548013161111143201259282340401449
2018;6245698013154105153199217
473:8655698013153101153169
725–738.10585698013154106159214261313365384
11.6245846013356101118
Chen7645846013364124179239
YB,10255846013360119142
Mirsadraei11895846013388114149193246308344397451477
L,1688584601335275
Jayakumaran1786584601334092142195246306397450485538598
G,2406584601337195
et2523584601335591
al.2636584601335378101
Somatic27595848013151109199248280302350
mutations31325848013190147181230262285342401440
ofTSC2or359558480131588737045848013149971542053931584801315991
mtor40445848013190122178210
characterize42765848013150107156187237286322373404427471522
a48215848013150
mor‑48935848013190149181210
phologically6245998013161119178201259319341389439461483530
distinct1175599801316082121155177235283319
subset1515599801314197157197250283
of1818599801315987
sporadic19265998013141100159191241300322371
renal2321599801312880138187209
cell25505998013149100123144
carcinoma2715599801314999130177198256314404453
with31885998013179102135193
eosinophilic34025998013153112152173231289349408430452473521
and39445998013150107167
vacuolated41315998013150100148206264287336368419479
cytoplasm.46305998013149100138194254277326365454473
Am6246148013164154
J8026148013138
Surg8646148013151107139197
Path10856148013155103135193
2019;13026148013154105153198216
43:15426148013154103119
121–131.1685614801315498145195241286332344
12.6246296013356104127
Trpkov775629601336291154205264315
K,1114629601336793
Bonert12306296013367128189244280319
M,15806296013388112
Gao17236296013372125185
Y,1931629601336782
et20366296013363100
al.2159629601336186109
High‑grade2299629801316991150208242304335385444497
oncocytic28206298013167125174230280330368390438
tumour32826298013142100189247305337
(HOT)36436298013137105178227260
of3927629801316695
kidney4046629801315478137195248296
in4366629801313189
a44796298013158
patient45616298013168118151173225283315
with49086298013180102135194
tuberous624644801313492151205237293351390
sclerosis1039644801314189111164196252292313352
complex.14156448013150105195255278331378398
Histopathology1837644801317091130165221281331363421480503561621669
2019;25316448013153105152197216
75:27716448013153103118
440–442.29136448013154110165223279335384402
13.6246596013356105126
Farcas7746596013353102137185238281
M,10786596013389113
Gatalica12146596013371125160213238263312365
Z,1603659601336083
Swensen17106596013354133187248290345406
J,2139659601334162
et2225659601335591
al.2340659601335378100
High‑grade2464659801316991150208241303335385444497
oncocytic29856598013159117166222271322359382430
tumor3439659801313492181239271
(HOT)3734659801312997171219252
of4010659801315987
kidney4121659801314771130188241288
is4434659801312362
characterized45206598013149107155187237285321372404426470522582
by6246748013161108
frequentTSC1,7566748013128611131732302833413731152674801314997154198211
TSC2and138267480131499715420516116748013150108167
mtor18026748013190122178210
mutations20356748013191148181231263285343401441
–24996748013155
a25786748013150
further2652674801312887118155214267298
characterization29746748013149106155186236285321372404426470521553575633691
of3689674801315887
an37996748013150108
emerging39316748013153142195227285307364423
entity.43786748013153111143165199250263
Lab46656748013149100160
Invest4849674801312380127179220254
2020;6246898013154105155206225
10:8736898013153101119
885.10166898013154108159176
14.6247046013356106128
Trpkov775704601335584146198257308
K,1106704601336085
Williamson12147046013393119145170194247338380440501
SR,17387046013355113137
Gao18997046013371124184
Y,2106704601335974
et2203704601335592
al.2318704601335378101
Low‑grade24427048013149106184217279311361420473
oncocytic29397048013158117165221271322359381429
tumour3392704801313492181239297328
of3744704801315987
kidney3855704801314670129187240288
(cd117-negative,4167704801312974131179220263290349403463512544566615667684
cyto‑48747048013149100138194229
keratin624719801314798130180212234291
7-positive):939719801315481142201241263296318367419444461
A14247198013164
distinct1512719801316082121156178235284320
entity?18567198013153111143165199250285
Histopathology2165719801316991130164220281331363421479502560620669
2019;28587198013154105153198216
75:30987198013154103118
174–184.3240719801315498143200246293348366
15.6247346013356106129
Shah7767346013354115169231
RB,10307346013359120144
Stohr1197734601335490150212249
BA,14707346013359125152
Tu16457346013354109
ZJ,17777346013360105128
et1928734601335593
al.2044734601335380104
„Renal2174734801313088142201252276
cell24747348013148100125148
carcinoma26467348013149100133181204263323414464
with31347348013179103138197
leiomyomatous335773480131217599158249296355446496530587646687
stroma“4070734801313975108166257307339
harbor44337348013159109142203264297
somatic4756734801313999189240273297347
mutations6247498013190148184235269293352413454
ofTSC1,11027498013158891215749801314898157203218
TSC2,1454749801314898157209228
MTOR17037498013182131201256
,19597498013119
and/orELOC200274980131501091712122663002326749801314893160221
(TCEB1)2569749801312881139187239284307
:28777498013119
clinicopathologic292074980131497396156179229287349401435494554579639701724774
and37197498013149109170
molecular39137498013190150175229281340364414447
characterization43847498013149109159192244294332385418443488541575599658718