577
208192226014562121182
ORIGINÁLNÍ852207016996181224324367468561635735777
PRÁCE1667207016983165262348424
Ces8507936014570127174
Urol10497936014578115180208
2020;12827936014562121178237261
24(3):15697936014561118151209238260
207–21318557936014561121178231286341393
Výsledky:1000896013361110150173225284332384404
U1419898013168
čtyř150289801314982130160
pacientek1677898013160107153172221276305353395
byla2088898013160104124170
vstupně227389801314987119173230285335
prokázá‑262389801316089143186234275323353
na8501048013158103
asymptomatickábakteriurie,96610480131498513021627130035243748251052957361566273578182285590293094910021030104910971111
kterábylapřed2090104801314679126154200273316336380453481529585
zaháje‑2688104801314491144189208257288
ním850119801315877162
instilací1033119801311671107138157176222267286
přeléčena1334119801316088136156205251299353399
pomocí17481198013160115201256302321
antibiotik.20841198013149104132151207227281311330372390
Z24891198013158
celkového2562119801314996116158211256305359414
počtu8501348013160116162195249
sedmi1114134801314191148233252
pacientek13811348013160107152171220275304351394
byla17901348013160104124170
jedna1981134801311766123178223
účastnice22191348013158103150186218273292337384
ze2618134801314492
studie2725134801314172127183202251
vyřazena8501498013150100130177220269325371
pro1246149801316191145
non‑compliance14171498013158115171202251305392450470490536591638686
po21291498013160117
sedmi2268149801314595153240260
aplikacích.25501498013153110131150193242288308354409426
Během8501648013156108164216304
plánovaných1182164801316283130186243290338395439485541
kontrol17461648013153108165195225281302
byla20761648013162107129176
asymptomatická2274164801315795143232290321376464511542562609653702
bakteriurie8501798013160108151185234263283337366386436
prokázána1302179801316090144188236278326381428
pouze17451798013161118173215264
u20241798013159
dvou20981798013160107161217
pacientek.23301798013161108154174224279308357400419
Sym‑2764179801315193181212
ptomatický850194801316090143229275305324369412460
uroinfekt1326194801315886140159214239288330364
byl17061948013160104125
za1846194801314492
dobu19531948013159114171227
sledování2195194801314060110167222267314369388
prokázán2598194801316089143186234276323378
pouze8502098013161118173215264
u11302098013159
jedné1211209801311768126181232
z14592098013144
nich.1519209801315978124180196
V17312098013156
obou18032098013159117173229
případech2048209801316190110168215272323370426
následovala24902098013159105143162213271326372420440486
standardní850224801314173121176233280309365420440
antibiotická13062248013150105135155212232288318338384427475
terapie1797224801313483112160217238288
dle2101224801316080130
citlivosti2247224801315069100120140187241279312331
bakteriál‑25942248013161109152187235265285331351382
ního850239801315978136192
agens.10642398013153111161217254272
Data13612398013171117147195
z15782398013147
kontrolních16472398013150104161190220274295350370416471
dotazníků21432398013160116146194236292312357413
prokázala2581239801316191145189238280329349395
jednoznačně850254801312474132188244284340387433489539
pozitivní14152548013160117157178209229276333352
efekt1793254801315379129172207
léčby2022254801312777124182227
a22702548013154
zlepšení2346254801314869119177214265321340
kvality27082548013150101148168188219268
života850269801314464111165195242
v11072698013150
porovnání11732698013160116146200245302348403422
se1611269801314191
vstupními1718269801314987119174231287306392411
dotazníky.21452698013159115145192234290309354403414
Statisticky2575269801315179126156176212244264309352401
signifikantní850284801314059114169187210237278326380409463482
zlepšení1347284801314463113169206255310328
tíže169028480131335393141
příznaků1846284801316088108148204249291345
bylo22062848013160104124179
zaznamenáno2399284801314492133188234319368423468522577
u8502998013158
všech923299801315087137184239
validovaných1178299801314996116135191246292339394437482536
dotazníků17302998013159115144191233289308353408
PUF21532998013155119166
(p<2340299801312381161
0,05),2517299801315368119167192205
OABq27372998013173131183240
(p850314801312987
<9563148013166
0,05),1041314801315469120169194207
ICSI1270314801312181130149
(p1441314801312684
<15443148013166
0,05)1629314801315368120169194
a18423148013150
ICPI1914314801312080132150
(p2086314801312684
<21893148013166
0,05)2274314801315469120170194
při2487314801316190111
poslední26173148013160117155175226284339359
kontrole,8503298013147101157187217271292342357
tedy1229329801313280139185
po14333298013161118
roce1573329801313084132180
od17733298013159117
zahájení1909329801314593149196216266322341
instilací.2272329801312176113146166185232278298314
Závěr:10003446013360110157207239259
Intravezikální1274344801312377105134180224272313333374422441494513
terapie1801344801313481109155211231280
roztokemhyaluronátu2095344801313285124157209252300385457500546565618646699754799828882
sodného850359801314197155211262317374
(Flaveran®)124535980131317897144189239268316371409434
prokázala1703359801316090144188237279328348394
statisticky2119359801314375123153173209242262308351400
významný2543359801315099144200247334389433
efekt850374801315379129173207
při1085374801316190111
léčbě1218374801312979126183235
LUTS14753748013155118167216
spjatých17133748013147104124170200249295350
s20853748013147
recidivujícími2154374801313887135154211231278334354374419439526545
uroin‑2727374801315888142162217249
fekty.850389801312979122157206217
Z10913898013160
hlediska1174389801315979130188208245287336
samotné1532389801314391178234264320371
prevence1927389801316190140186236292338387
recidiv2336389801313483131150207227274
cystitidy2634389801314998136168188219239296342
byl8504048013161106127
rovněž999404801313690136193244286
zjištěn130640480131496989125157206262
terapeutický1589404801313887116164221273328359379425468518
efekt.2132404801315480130173208225
Za23824048013159107
souhrnnou25114048013145101157212241298353409465
dobu8504198013162120180239
sledování1112419801314869122183241289339397417
tak1552419801314291136
byla17184198013163110132180
prokázána1928419801316294150196247291342400449
pouze24064198013163122180224276
jediná2705419801313083143164222271
symptomatická850434801314188176233264318405452482502548591640
epizoda15064348013153111131173227285332
uroinfektu.1854434801315887142162217243293336371426443
Léčba2313434801314999146203251
byla25804348013161106127173
dob‑27694348013160116174207
ře850449801313282
tolerována953449801313892113164193247293341396443
a14184498013154
za1494449801314896
celou16124498013153102122178234
dobu18714498013160116174230
jsme2123449801312764151202
nezaznamenali23504498013159110153201243300347433484540587607626
jediný850464801312474132152207251
nežádoucí11214648013158109151200257313369415435
účinek.15754648013159105124180231274293
KLÍČOVÁ8524934014770132164236320392464
SLOVA13434934014762123207279351
Cystitida,8505098013163104145179201235257316364383
intravezikální1257509801313087119151201248300345367412463485543564
instilace,1846509801312987126161183205253302353369
kyselina22405098013153104145198220242300348
hyaluro‑26125098013166112162184241272329364
nová,8505248013159117165215234
recidivující1108524801313284133155214236285344366387435457
infekce1589524801312381108161206253304
močových19175248013190149198254302354402459
cest.24005248013149100141175194
SUMMARY8525534014762143243345423493561
Horňák10005698013169126157215263307
J,1331569801313350
Veselý14005698013156104144196218265
Š,1685569801315066
Havlová17715698013168116163186243290339
K,2130569801315475
Babjuk22245698013155104163185241285
M.25295698013185104
Preven‑2652569801315585135183234291324
tion850584801313455112169
of1038584801315886
recurrent1147584801312879127183214245296352383
cystitis1550584801314898138171193225247285
with18545848013178100133190
intravesical2067584801311975106137186233283323343391439461
instillation2551584801311975114147169190211258290311368425
of850599801315987
hyaluronic9615998013159105155177234265322380402450
acid1435599801315099121180
Flaveran®.1639599801315172120168220251301359399413
Objectives:10006146013378144171228280320347402457502525
Our15606148013176137170
aim1755614801316184176
was19656148013182134175
to21666148013144102
investigate2294614801313292141195238274297359410444497
the28166148013144105160
efficacy850629801315380108136185235283334
of1212629801315987
Flaveran®,1323629801315576124172224255305363403415
when17666298013179138191249
treating2039629801313870121169201223281340
recurrent2403629801313788138195226259310368400
uri‑2831629801315890112145
nary8506448013159107138190
tract1064644801313062111160196
infections1284644801311976104156205241263320379418
(UTIs)1726644801312592144167206231
and19776448013150107167
concomitant21646448013149104163211267356378411460518549
lower2737644801312077155207238
urinary850659801315890112170219250302
tract1176659801313465115164200
symptoms1400659801314191181240273329419458
(LUTS).1882659801312977142194245273288
Methods:10006746013390147184246307371415437
In1462674801313292
a15786748013160
prospective16636748013170103160202262317368405428479532
non-randomised22206748013168128187222255307366427486578600640695756
study,850689801314073129187233246
from1118689801312456111198
2018–2019,13356898013152102148193247293343389432445
we17996898013178128
included1950689801311974121142197255306364
723336898013153
patients24046898013160108139160211267297337
aged27606898013149106158216
228507048013154106
to980704801313692
4410987048013154111
years.12337048013150102150181222242
All1501704801316487108
were16357048013180132163215
diagnosed1876704801316082130189247305345398459
with23617048013179102135193
recurrent2578704801313586136193224257308366398
UTIs8507198013169122146186
according10607198013158107154211243302324382442
to1527719801314298
European16507198013160115147204265320368427
Association21017198013173115156214264286335368390448508
of2633719801316796
Urol‑27617198013170101158181215
ogy8507348013159119167
(EAU)1041734801313383148212240
criteria,1305734801315384107140191222245293312
meaning16447348013190143191249271328388
three2056734801313795126178232
confirmed23127348013152108167192219250340393453
UTIs27937348013168120144183
per8507498013162118151
year10267498013158111161194
or12457498013168102
two13727498013143127186
symptomatic15837498013151102195256290348440491524547597
UTIs22147498013170124149190
in2429749801313291
a25457498013160
span26307498013151112163223
of2878749801316998
six850764801314163111
months.9937648013191151210242301341361
During13877648013172131162186244304
a17167648013158
baseline17997648013169120160214237259317371
examination21957648013162110160250272331380413435494553
they27737648013142101155203
underwent3203898013159116176229261343395453485
a3712898013158
cystoscopy3794898013158109149184240280329385446493
with4319898013180102136194
a4537898013158
mucosal4627898013191148197253293343365
biopsy,501689801316992150210250300313
ultrasound3203104801315881114145195235293351409468
of3695104801315887
urinary3805104801315889112170218250301
tract,4131104801313364114163199218
urine4372104801315990112170223
culture,46181048013149107129162220251303319
uroflow‑4961104801315889146172198256334368
metry32031198013190143176208260
and34871198013153111170
in3681119801312684
case37891198013152101141194
of4010119801315987
persistent41241198013161115146187208247282333391422
strong4571119801314378110166225284
urinary4882119801315890112170219250302
ur‑5211119801315889118
gencies32031348013160113171219241294334
cystometry.35611348013154105146180236326379412444496509
The40941348013156116169
treatment4288134801313970122170202292345403434
comprised47471348013154110199259291313352406466
of5237134801316492
1032031498013154101
intravesical3329149801313189121153203251304344366414464487
instillations3840149801313189129164186208230279312334392451491
in4355149801313189
one-week44681498013167126180215295347401448
intervals.4940149801313189121172204257308330369389
The32031648013153115171
efficacy3399164801316492121150201253304357
was37901648013182134175
evaluated39911648013164115167190250301335388451
after4467164801316090129183216
647081648013164
weeks,48071648013181136192240286305
3,5138164801316482
6,5246164801316483
123203179801315397
months33381798013189147204235292330
using3687179801315896117173232
the3942179801312986138
following4104179801312480102123180257279335393
validated4517179801314997119140198245277326385
question‑49221798013159115166206239261317375407
naires;32031948013159108130161212252269
Pelvic34981948013156106129178201249
Pain,37731948013155103125183201
Urgency,4000194801316899157210268317368381
and44051948013151109169
Frequency4598194801315381133193250303361410461
(PUF),5083194801313185151201230246
OverActive32032098013174125176208266313350372421473
Bladder3702209801315578127186246298330
syndrom4056209801314392151210242298388
questionare44702098013159117170210244266324383431463514
(OABq),50082098013131102162217276305321
Interstitial3203224801312381113164195236270292326348396418
Cystitis36412248013163104145179202235257296
Symptom3957224801315196186245278334424
Index4405224801311977136189237
(ICSI),4666224801312547109161182209225
Interstitial4915224801311977109160191232266288322344392414
Cystitis32032398013163104145179201235257296
Problem3523239801315585142202225278367
Index3914239801312381141193241
(ICPI)4179239801312951113167188215
and44182398013150108167
urine4609239801315990113170223
cultures.48562398013150107129162220251303343363
Results:33532546013359114157217242278322344
Four37212548013156112170202
patients39522548013160110142164217275307348
had43292548013159108168
a45212548013154
positive46042548013161120160182215237286338
baseline49712548013161111150203226248305358
urine3203269801315990113172225
culture34532698013157115137171229261313
that37902698013143101151183
was40062698013180130170
treated4201269801314274126175207259320
by45452698013169117
a46862698013159
short47692698013149107166199236
course50302698013157114172204245299
of3203284801315988
antibiotic33152848013158117149171231254312345367416
therapy.37552848013142101154186237297344358
Out41452848013175134168
of4337284801316796
744572848013162
patients,45432848013170120152175228286318360379
one49472848013167126179
was51592848013179130170
excluded32032998013153101148170227286339399
because36222998013161115164214271310363
of4005299801315987
non-compliance.41132998013159117175208259315405464487508557614663714731
During48642998013171129161183241300
the5188299801313088141
follow3203314801312986109131189267
up34933148013158118
we36333148013180132
recorded3789314801313183132188220278331391
two42043148013133114172
episodes43983148013154113136175233293346386
of4807314801315987
asympto‑4917314801315089139229288321377412
matic32033298013190139171193241
bacteriuria34653298013160110159195246277300356387410458
in3947329801312077
two40483298013130112169
patients42383298013160110142164217275306348
and46063298013150108167
one47943298013158117170
episode49843298013153113135174232293345
of3203344801315886
symptomatic3309344801314089178237269325413462493515563
UTI38913448013169120143
in4058344801311976
the4157344801313087140
third4320344801313088109139197
one.45363448013158116169186
All4741344801316486107
cases4868344801314998137189229
were51173448013179130161212
resolved3203359801313284124182206255306367
by35923598013160107
a37213598013150
course37933598013149105163194235288
of4103359801315987
antibiotics.42123598013150108140162221244301334356404446465
Data46993598013171120152202
from4925359801312760116206
vali‑5153359801314999121143176
dated32033748013159107138188247
questionnaires34703748013158114166206239261317375431479500530581620
demonstrated41093748013160111199256313352386417465497547606
positive47343748013160118157178210232280331
effect5084374801315381110161210245
on32033898013159117
LUTS33443898013150115167218
and35873898013150107167
the3778389801313593146
general39493898013160112170223255305327
quality43013898013159117165188209242294
of4620389801315887
life473138980131244574126
compared48813898013150106195255305336387448
to3203404801313490
the3317404801313088141
baseline34784048013161110150203225247304357
information.3859404801311977104161193283331364385443501520
Statistically4399404801315182132164186224259281329378401422470
significant4889404801314162121179200226253301351408440
differences3203419801316082111141193224276333382433473
were37074198013180132163215
achieved39464198013157106164185238287338399
during43694198013167124155178235295
the4688419801314199152
last4864419801313180119154
visit5042419801315780119140173
at5239419801315890
12th3203434801315499330243540762055
month,33814348013199157216248307325
PUF37304348013164130180
(p3935434801313798
<40654348013166
0,05),4155434801316280134185213228
OABq44164348013174135189249
(p4690434801313798
<48204348013166
0,05),4910434801316280133185212228
ICSI5162434801313294146167
(p3203449801312989
<33174498013165
0,05)3406449801315471125176203
and36334498013150108167
ICPI3825449801312385139159
(p4008449801313090
<41224498013166
0,05).4212449801315371124176203218
Conclusion:33534646013365125187237263324368394455518540
Intravesical3918464801313291123156207256309351373422473496
instillation4439464801313291132167190213235285318341400460
of4924464801316898
hyalu‑50464648013169116167190249283
ronic3203479801313289147169217
acid3442479801315099121180
(Flaveran®)364647980131277697146193245277327384425452
proved4120479801316092149197249309
to4453479801313288
have45634798013159108156207
a47924798013150
statistically4866479801313974124156178217251273322371394415463
significant3203494801314162120178199225251299349406437
effect3660494801315382112163212248
when39284948013179137190247
treating4199494801313061112160192213271329
recurrent4552494801312980129186217249300357389
UTIs49604948013169120144183
and51634948013149107166
concomitant32035098013150108169219277370393427479539572
LUTS.38005098013159126180233253
Over40875098013176128182215
a43275098013160
12-month44125098013164110141235295356389449
follow-up4886509801313897122145205285320381443
period,32035248013161115146169226287305
we35285248013180132
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only40935248013159117139187
one43015248013158117170
episode44915248013154113136175233293346
of4858524801315887
sympto‑4965524801314190181240273329364
matic32035398013190139171193241
UTI.34765398013169121145164
The36645398013159119172
treatment3861539801314173125173205294348405437
was43305398013180129169
well45315398013180132154176
tolerated4731539801314298121174205255287338399
and51545398013158115175
no32035548013159117
side3344554801314163122175
effects3543554801315382112164213249291
were38585548013180132163215
recorded.4097554801313284133189221279332392411
KEY32045834014770134206
WORDS343758340147105189260345408
Cystitis,32035998013163104145179201235257296314
hyaluronic35405998013159105155177234265322380402450
acid,4013599801315098120179197
intravesical4234599801312279111143193241292333354402452474
instillation,4732599801312279119153175197219267300322379438456
re‑5212599801313183117
current32036148013149106138170222279311
urinary3538614801315990113170219250302
tract3864614801313466116164200
infections.4089614801312380108160209246268325384423443
………320364340147120240360
ÚVOD32056858018197183286388
Infekce3353719801312381109161206254304
močových36857198013190149198254302354401459
cest41687198013153104144179
(UTI)43717198013132100152175203
jsou4598719801312766125183
považovány48087198013161120168218263319367417475521
za3203734801314494
nejčastější33177348013159111133181230269303353375413434
bakteriální37717348013160110155191242273295343365422443
infekce,4238734801311976103154200246297313
přičemž4571734801316092114161211300343
ženy4934734801314495152198
jsou5156734801311958116173
postiženy32037498013161120159194216259310368414
častěji3637749801314998138172223244266
než39237498013159112156
muži.40997498013190147191213231
Udává43517498013168127176223273
se,4644749801314194110
že4774749801314596
každá4890749801314697141199247
třetí5161749801313062113146168
žena3203764801314494151198
do34207648013159116
věku35557648013149100144201
2437757648013153100
let3898764801311970103
prodělá4020764801316091146205257278326
alespoň4365764801314970122161219277334
jednu4722764801311971130186242
epizodu49837648013153111133176231290346