612
28223226014562121
ORIGINÁLNÍ852207016996181224324367468561635735777
PRÁCE1667207016983165262348424
Ces8507936014570127174
Urol10497936014578115180208
2021;12827936014562121178233249
25(1):15567936014562122153207231253
27–3418357936014561118172231292
ky85089801314797
nesignifikatních969898013165116155174232288308332358402451481538557603659
a1651898013156
17,61729898013160102106158
%1910898013187
klinicky20198980131537595151170217261310
signifikantních.235289801314766123180199223250293342399429485505551607624
U8501048013170
rebiopsií942104801313989147168224283322341361
pak13251048013168116160
bylo15081048013167113134191
prokázáno1721104801316898153198247290340396453
53,621961048013160109124177
%23951048013188
karcinomů,25051048013153103132178198254311399455471
z8501198013144
toho915119801312780135190
38,6%klinicky1127119801314795111162257318340358412431476519567
nesignifikantních17151198013152102139158213268287310336378426480509564583628682
a24181198013143
15%klinicky2483119801314688183244266284338357402445493
signifikatních.850134801314159115169188211238280327357412430475530546
Při141713480131487695
porovnání15341348013154109139192237293338393412
výtěžnosti1967134801314392126174215270325362394413
dle2401134801315373122
daného2545134801315398153203258313
PI­287913480131486697
‑RADS850149801313285147213259
skóre1130149801313476129158206
bylo1357149801315397117171
ve1549149801314391
skupině1661149801313476130186205259309
PI‑RADS199114980131486596149211277323
323351498013146
celkově2402149801314290109151204248297
68,5%2720149801314696112162256
negativních,8501648013159110168214244264311368388433489505
31,51377164801315094103155
%15531648013178
pozitivních16531648013158115155175206226273330349395451
(27,82126164801312675122126179
%23271648013178
nesignifikant‑24271648013156106144164220276295319346389437493522549
ních850179801315978124180
a10521798013146
3,71120179801314964114
%12561798013177
signifikantních),1355179801313756113169188212238281330385415471491536592615628
ve2005179801314696
skupině2122179801313880136194214269320
PI‑RADS2464179801315170101156219287334
428201798013150
to2892179801313084
bylo8501948013161106127183
44,310541948013151105120172
%12481948013178
negativních13481948013156106165211241261308365384430485
a18551948013147
55,71924194801315198111161
%21071948013178
pozitivních22071948013158115155175206226273330349395451
(41,82680194801312673116126179
%,2881194801317895
resp.850209801313383121179194
13,910672098013160103117166
%),12552098013188111125
ve14022098013156106
skupině1530209801314891147205226282333
PI‑RADS1885209801316281113168232301348
522562098013160
pak23382098013167115159
22,925192098013160111127175
%27172098013187
ne‑28262098013166117150
gativních,8502248013161109141161210269289336394410
77,112832248013161113118163
%14692248013190
pozitivních15822248013168127168190222243291350370418475
(43,82080224801313685134149204
%23072248013189
resp.2419224801314091130189205
33,326472248013161110126179
%).28492248013189113127
Prokázal850239801315583138182230273321341
se1213239801313889
statisticky1323239801313870118148167204237256303346395
významný1740239801314696140197243330386429
rozdíl2191239801312984124179199221
ve2434239801314696
výtěžnosti2552239801314696131179221278334372404424
biopsií850254801316181137195233252272
(P1144254801313511752546013356
<12532548013172
0,001).1347254801315974126179224242255
18216242548013160104153
pacientů17992548013166114161180231287316372
absolvovalo21932548013156113151207228275330376424444500
výkon27152548013156106150205261
zcela850269801314487135154199
bez10702698013154104146
komplikací.1237269801313992178234254272314361407425441
Stran1699269801314472100147201
infekčních192126980131167095143186229283302346401
komplikací2343269801313992178234254272314361407425
jsme2789269801311753138187
zaznamenali850284801314492134190237323373428475494513
pouze13852848013154111166208257
dva16632848013154101148
pacienty18322848013155102148167217273302351
s22042848013135
dysuriemi,2261284801315399137191219240289376395410
ale2693284801314463113
bez28282848013154106148
průkazu850299801316191146189238280336
bakteriální12082998013159106150184233262283329349404423
infekce.1653299801312176102152195240289304
Závěr:10003143013562121177235276305
Výtěžnost13403148013156108148201247308369411448
transperineálně1814314801314579131191233295351385410469525575600660715
provádě‑25553148013171106165215267329384421
ných8503298013158104152210
fúzních1085329801312686130189212260318
biopsiích1428329801315881139200240263285334392
prostaty1845329801315790147187223273306357
v22273298013147
našem22993298013156105145198287
souboru2611329801313896155214274307365
odpovídá8503448013159121183244295320381432
literárním130834480131254884137171223256317341432
údajům.17673448013159121172196255346367
Zaznamenali21613448013160112159220271362417477528553576
jsme2764344801312566156212
minimum8503598013191116177202294355448
komplikací,13253598013157118211274300325373427479504524
a18763598013162
proto19653598013172107167202262
se22543598013152108
domníváme,23893598013171133226288312365418511567587
že850374801314498
takto974374801313688136175233
prováděné1233374801316398156207259321375435491
biopsie1750374801316388148210252276331
jsou2107374801312667127188
bezpečnou23213748013163119166229285336396457517
al‑2864374801315277112
ternativou.850389801313487121182233267291343402462483
KLÍČOVÁ8524184014770132164236320392464
SLOVA13424184014763124208280352
Diagnostika,850434801317194142201259317357392414459510528
infekce1403434801312178106158204251302
močových17294348013188147196252300352399457
cest,2210434801314798139173192
MRI/US24264348013184139162200269317
navi‑27674348013157106153176209
govaná8504498013160118166216274323
biopsie,1197449801316083141201241262315332
transperineální1553449801313465115173212272326357380437490538561618640
biopsie2217449801316083141201241262315
prostaty.2556449801316193149189224273306357370
SUMMARY8524784014762143243345423493561
Ryšánková10004948013154102141190245289344391439
K,1462494801314969
Hanzlíková15544948013163111167209231251297352399447
P,2024494801314953
Vrtková2100494801315079114158213260308
A,2431494801315878
Albínová2531494801315980138159215271318366
T,2920494801314556
Jendřejek850509801313890148207237288310362407
M,12815098013181100
Krhut1405509801315083141198231
J.1660509801313351
Transperineal1734509801314772121178217276329360383440492540562
prostate2319509801315788144184218267299349
biopsy2692509801315779136196235284
navigated8505248013159108155178237286318369429
with13035248013180102136194
US/MRI15215248013169117154238293316
fusion.1861524801312988127148206265283
Major10005393013591146173234272
statement:129453930135468313917523032237844047617705398013119
US/MRI18125398013169116153235289311
fusion2146539801312987125145202259
transperineal2428539801313565114171209267320350372428480527548
prostate850554801316091145184216264295344
biopsy1216554801315677132191229277
has15155548013154101139
comparable1676554801314498185243291321369427448499
yield2198554801314364115136193
and24135548013145101158
lower2594554801311874150201230
risk284755480131274885129
of850569801315986
infectious959569801312076103154202237258315372410
complications13925698013146101189248270290337386417438494552590
than2005569801313188135192
transrectal2220569801313162110167205235286334369418439
biopsy.2682569801315779135194233282294
Purpose:10005843013563127167234299346405431
Nowadays,14575848013180141222274335386434477496
prostate19795848013171104163204241292326379
biopsies2383584801317195155217259282336378
per‑27875848013170127159190
formed850599801312987120212266327
transperineally1202599801314375126185225285340372396454508557580602651
are1878599801315991143
gaining20465998013169119141200222280341
prominence.24125998013169102160251273332386445495546564
In850614801312483
our9586148013168127160
cohort,11436148013158115176235268306326
we14946148013189143
retrospectively1662614801314194128161219260321377427465488538591615664
evaluated23516148013163113164187246296329381443
the28196148013143103157
yield850629801314871124146206
of1080629801315584
transperineally1188629801313163113171210269323354377435488536558580628
performed18406298013158112143175232264354407468
biopsies2332629801315880138198238259312352
and27086298013147105165
at2897629801314779
the850644801313492145
same1019644801314494183237
time1280644801313759147200
their1505644801313795148169201
safety,1730644801314494122174207258271
especially2025644801315797156210260281330352374422
with24716448013182105138196
regard2691644801313587147196227285
to850659801313490
infectious964659801312381108160210246268326384423
complications.14116598013149105195254278299347397429451509568607626
Patients10006743013561114149175229290325369
and13906743013559119181
methods:15926743013596151187248307369413436
From2078674801315481135223
January2323674801314187143198244273323
201926686748013157107152195
to2885674801313791
March8506898013184130158201256
2020,1127689801314694140189203
we13516898013172120
performed14926898013154105133162215244330380436
2081949689801314795145
fusionUS/MRI2115689801312278114132186241324368402482534554
guided26906898013152106125180230286
prostate850704801316192147186219267298347
biopsies1220704801316788145204242262313352
–15947048013162
transperineally.1678704801314171120176214272325355376432484530551571617629
Magnetic23307048013192140198255307338358405
reso‑2758704801313989128185218
nance8507198013158103157201248
imagingwas11197198013116100145201219273328420466502
evaluatedby1642719801314690136155208253282329385459502
the2165719801312781130
PI-RADS231671980131476595148209275321
vs2658719801314279
227577198013146
and2824719801314396152
vs850734801315088
2.1960734801315974118
scoring1100734801314692146176196252309
systems,1431734801314693131164213299337353
respectively.1806734801313887125182234281315335382432452498509
In2337734801312884
biopsy2443734801316586141199237284
naive27497348013164111130177227
patients8507498013161108138158209264294333
we12057498013183133
performed13607498013164116145175230260347398456
systematic1838749801314592130162211298345375395441
biopsy2301749801316484139198235282
from2605749801313363118205
the2832749801313793144
peripheral8507648013160112141161218274324353401421
zone1292764801313892148199
and1513764801314399155
took1690764801312881138182
at1893764801314474
least1988764801311868113151183
three2192764801312884113161213
samples2426764801313583169226247297335
from2782764801312354108195
the320389801313491142
lesion336789801313081120139195252
described3641898013167118156203233254312364423
by4086898013167113
the422189801314097148
radiologist.439189801313987145165221242299358378415448465
In487889801312985
patients4986898013167115146166217273303343
with32031048013180101132189
repeated3414104801313988146199245276325384
biopsy,3820104801316788144202241288299
we41421048013186136
made43001048013197144202253
a45761048013156
targeted4654104801314088118174225256306364
biopsy5041104801316787143202240288
with32031198013179100131187
at3412119801314575
least3509119801311869115152185
three3716119801312985114163215
samples3952119801313785171229250300338
from4312119801312455109197
the4531119801312985136
lesion4689119801311869107126181238
or4949119801315383
lesions5054119801311969107126182238275
PI-RADS3203134801315472102155217283328
≥3,35521348013158126139
but37121348013153108138
we38711348013171120
didnotmake4012134801315271126198253282385430472520
a45531348013142
systematic4616134801313480117148195280325354372417
biopsy.5054134801315373126183219265275
Results:33531493013562118164225253291337361
The37381498013147106159
overall39211498013154102153184234256277
yield4222149801314467119141200
of4446149801315482
the4552149801313087140
method47161498013186138171228286346
in5086149801311976
our51861498013154112142
group,3203164801316091147205264281
regardless3508164801312880140188220277299352392432
of3964164801315482
the4070164801313188141
PI-RADS4235164801315272106163228298347
score,4606164801313786142174225242
was48721648013175125164
52.950601648013150100118168
%52521648013177
of3203179801315784
proven3310179801315586141187237293
cancers3626179801314492148195244274313
in3962179801311874
biopsy4059179801315576132191229277
naive43581798013154101122169219
patients,46001798013155103134155206262292332350
of4973179801315380
which50761798013173130150197253
35.332031948013154103120173
%34001948013178
were35011948013176128159210
clinically373519480131466789146168216265287309357
insignificant4116194801311976115136195253274300327375424482514
and46531948013147104163
17.64840194801315093101154
%50181948013177
were51191948013175127159210
clinically320320980131497193150172220270292314362
significant.3589209801314062121179200226253301351409441460
In4073209801312380
rebiopsy,4177209801313284144166224284324373386
53.645882098013153103120174
%47862098013180
of4891209801315886
cancers5001209801314998156205256287328
were32032248013182136169223
detected,34512248013170125160213265303356418438
of3914224801316999
which40382248013190151174225285
38.643482248013164118139195
%45682248013192
were46852248013191145178232
clinically4942224801315983105165188238290314337387
insignificant3203239801312381120141200258280306332381430488520
and37472398013150108167
153938239801315499
%40612398013181
were41662398013179132163214
clinically440523980131497192150171220269292313361
significant4790239801314163122180201227254302352410442
When33532548013190147198254
comparing36292548013153106194251299328348404461
the4112254801313894145
yield4279254801315273123144201
according45012548013154101145199229284304359416
to4939254801313892
the5053254801313894145
PIRADS522025480131597832032698013156119187234
score,3459269801313985139169218233
in3713269801312176
the3811269801313288139
PI-RADS3971269801315372104158221289337
343292698013152
group4403269801315786140196253
a46782698013148
total4748269801313185115163183
of4953269801315682
68.550572698013151103120171
%52502698013179
were32032848013180131160210
negative,34352848013166117176223254274321372387
31.538442848013160104115167
%40332848013188
positive41432848013167125163183214235282332
(27.84498284801313585133138191
%47112848013188
insignificant4821284801312985123142200256276300327374422478508
and32032998013150106163
3.73388299801315369118
%35282998013181
significant),3631299801314160117172192216242288336392421447460
in4113299801312378
the4213299801313490141
PI-RADS4375299801315674106160223291339
447352998013154
group4811299801316089143199256
it5089299801312354
was51652998013179127164
44.332033148013155112129183
%34093148013191
negative35233148013168122182231263284333385
and39323148013158116176
55.741313148013163112128180
%43343148013191
positive44483148013170130169190223244293345
(41.84816314801313888133144199
%50383148013191
and51523148013159117177
13.93203329801315496112160
%,33853298013183101
respectively),3507329801313685123180232279313333380430450496520533
in4062329801312681
the4165329801313793144
PI-RADS4331329801315876108162226293341
546933298013157
group4772329801316291146202259
22.950533298013156107122170
%52453298013184
negative,32033448013159110168214244264311361376
77.136003448013154104108152
%37743448013181
positive38773448013160117154174205225272321
(43.84220344801312976123139191
%44333448013181
and45353448013150105163
33.347203448013153100116168
%,4909344801318198
respec‑5029344801313281119176228275300
tively).3203359801313454101151171217241254
There34793598013153111162191240
was37413598013182129167
a39303598013152
statistically4004359801314375123153173209242262308355375395440
significant4466359801314463120175195218245291339394424
difference4912359801316281108138188217267322369417
in3203374801312378
the3303374801313086137
yield3462374801314464115135192
of3676374801315480
biopsies3778374801315777133191229248298336
(Chi-square4136374801312582137157188226283338385414463
test4621374801312978116149
of4792374801315480
independ‑4894374801311974131182239291347404435
ence32033898013153109155204
for3429389801313388118
contingency35683898013153107164193213268326376432478527
tables,4117389801313885143164214252269
P44123896013356
<44893898013170
0.001).4581389801315773124177222240253
We48563898013194142
also5020389801315474110166
as‑5208389801315492121
sessed3203404801314192130168218276
the3501404801313894145
complications36684048013152106193251272291337385415434490546583
of4273404801316289
the4384404801313793144
procedure4550404801316494148196244302357386436
and50074048013154110167
we51964048013183133
found3203419801312985141197255
that3480419801314097144174
18236764198013160105154
patients38524198013167115146166217273303343
underwent42174198013165121179230260340391447477
the4716419801314197148
procedure4887419801316797152199249307363392442
without32034348013181101133190247304336
any35624348013157113158
complications.37424348013156111200258280300347395426446503561599616
As43814348013171112
our45154348013166123152
main46904348013197145165221
outcome49344348013165122154199254343395
measure,32034498013190140186223277306355370
infectious359444980131177298147194228248303358395
complications,4011449801314396183241261280326373403423478534571587
we46204498013173123
recorded4765449801312675122175205260311369
only51554498013153109129174
two32034648013134113169
patients33934648013166114143163214269299339
with37534648013184105136192
dysuria,39674648013164110149203232252298315
but43044648013165121152
without44784648013184104136191247303335
evidence48344648013158105126183233289335384
of5240464801316389
bacterial32034798013161108155189238267287333353
infection.3578479801312176102152199233253308365381
Conclusion:33534943013565125188238266328374401463526551
The39354948013151111165
yield4124494801315679132155214
of4362494801316795
transperineally4481494801314274124182222281335367390447500549571593641
per‑51464948013169123154184
formed3203509801312985117206259319
prostate3545509801315789145184218267299350
biopsy3919509801315678135195235284
in4226509801311976
our43265098013155112143
cohort44935098013145100158216248284
corresponds48015098013145100132164215255313372430489528
to3203524801313592
literature332152480131325489141174226259318351404
data.37505248013169120153204224
We399952480131101153
have41775248013168119168221
noticed44235248013169129162185235288350
a47985248013159
minimum488252480131101124183206297356447
of3203539801315988
complications,33165398013158115206267291313362413445468527586627646
and39875398013158117178
therefore41905398013142101155188240269327360412
we46275398013189142
believe47945398013169124148170223273326
that51455398013142101151184
biopsy3203554801316183141201241291
performed35185548013160114146178235267357410470
this4012554801313492114153
way41895548013180129176
is4389554801312362
a44755548013150
safe4549554801314191119171
alternative.4744554801315072106157188247296328350399451468
KEY32045834014770134206
WORDS343658340147106190261346409
Diagnostic,3203599801317194142201259317357392414462481
fusion3708599801313695134156214272
MRI/US40045998013193148171209278326
prostate43545998013168100157197232281313364
biopsy,4742599801316991149209249299312
trans‑5078599801314173123181220251
perineal32036148013161115146169226279327350
prostate3577614801316092149189224273305356
biopsy,3957614801316184141202242291304
urinary4285614801315890112170219250302
tract4611614801313466116164200
infection.4835614801312381109161210246269326385404
ÚVOD32056558018197183286388
Karcinom32036898013155109143193217278339432
prostaty36626898013171106166208246298333387
je4076689801313490
v41936898013160
západním42806898013155109171224287347372464
světě47716898013151105159195249
druhé50466898013171105166227283
nejčastější32037048013159114138189240282319372396437461
maligní36907048013192144168192253313337
onemocnění40537048013161122177268329380440495555579
u46597048013160
mužů.47467048013192151197257277
U50497048013171
kaž‑51467048013149102149183
dého32037198013159113172232
sedmého3460719801313993154244298357417
až3902719801314893
pátého40217198013158109143195254313
muže43607198013187145190243
je4628719801312275
během47297198013158113172226316
života5070719801314266117175208259
diagnostikován3203734801316085136199259321364401426474534585638698
karcinom39287348013158111146195220280342435
prostaty43897348013172107166209247299334388
(1).4804734801314090113131
V49627348013167
České50567348013173127171218273
republice3203749801313390155218283311336389445
byla36777498013180132159213
v39187498013169
roce40157498013151113167223
201742667498013173130182231
hrubá45257498013178114177242297
incidence48507498013141104158184248306369423479
15032037648013155103158
mužů/100338876480131103164211273315369420478
tis.389476480131325799122
osob40437648013170114176240
(2).4310764801314095125143
Jedinou44807648013149106170195256318380
možností488776480131103165211273335379417442