561
395610226014562119
Ces37957936014570127174
Urol39947936014578115180208
2022;42277936014562121178238261
26(1):45147936014561119152206230252
38–4847927936014561121183248310
ORIGINÁLNÍ3862207016996181224324367468561635735777
PRÁCE4677207016983165262348424
může624898013190147191242
být890898013168115152
ohrožena1066898013166124155212255306364413
účinnost1503898013165113135192250308348383
jedné191089801313083143201254
z2188898013151
posledních2263898013168127167189242302360381429487
skupin624104801314186144204226284
antibiotik.9321048013156114145168227250307340362407428
Antimikrobiální13841048013171129161183271293338372428488511559581639661
rezistence,2069104801313890134157196230281339388439456
kon‑25491048013152109168201
krétně624119801314780131165223276
na9241198013166115
beta‑laktamová10631198013168122156205239262311357393443532590638688
antibiotika,17751198013158116147170229252309342364409460478
byla22771198013169116139188
na24891198013166115
JIP2628119801314668122
signifikantně624134801314265126186209236263310363423456517572
vyšší12211348013160114156197220
ve14661348013160114
srovnání1605134801315183142192253304364387
se20171348013151106
standardními2149134801315086138198260310343403463486578601
odděleními6241498013159119178231253306364386475496
(p1144149801313090
<12581498013166
0,00).1348149801315371124179206221
Závěr:7741644013562118170224262288
Hodnocená10851648013169127186242300348398455502
data16101648013162110141190
prezentují1823164801316394144187238295325382403424
vývoj22701648013152102155211232
AMR.25251648013166151204224
Minimálně6241798013186107163184271319340397448
každý1095179801314292136192239
10.1357179801315096112
pacient14921798013157106153174225282313
léčený1828179801311970119168225270
pro2121179801315687142
infekci2286179801311975102153198244264
mo‑25731798013186143177
čových6241948013149104151202248305
cest9521948013152101141174
(IMC)1149194801313253136197226
v13981948013153
našem14741948013161109147199287
zdravotnickém17841948013147104134183230286317374395442486537625
zařízení2432194801314796126148190241298318
trpí624209801313465124145
rezistentní792209801313182125147185218268325355413433
infekcí.1248209801312278105156200246267284
Výskyt15552098013155103142186237273
nových18512098013158115162213259316
typů2190209801313282142199
antimik‑24122098013149105136157244265309338
robiální624224801313288147168215236292312
rezistence,959224801312878121143180214263320367417432
které1414224801314277127157207
dříve1644224801315585106154205
nebyly18712248013154106165210233279
v21732248013145
našem22412248013154101139191279
zdra‑2543224801313996126174207
votnickém6242398013150106137194214262306356444
zařízení1091239801314089119140183233290311
pozorovány,14252398013156114155210241296343392449493505
je1953239801311971
vážnou2047239801314593136194251308
hrozbou.2378239801315484139180240298355372
KLÍČOVÁ6252684014770132164236320392464
SLOVA11152684014763124208280352
Antibiotická6242848013165124156179239262321354377426472523
mikrobiální11722848013199122168202259320343392415473495
rezistence,1692284801314193139162202237289347397448466
ESBL,21822848013160112166216236
AmpC,24422848013174164225289308
CPE,6242998013163116165184
VRE,8322998013156112163182
MRSA.10382998013185140191254275
SUMMARY6253284014762143243345423493561
Paldus7743448013156105127187245285
V,1083344801316577
Šámal11853448013159110200249272
V,1482344801316476
Fáčková15833448013159104153199256305356
D,1963344801318096
Mečl20833448013195149199221
J.2329344801314664
Antimi‑24183448013173132164186276298332
crobial624359801314980137197220268290
resistance938359801313485126147186220270328376427
development13893598013161114163215237295356445499556588
–20013598013156
prevalence2082359801316193145194243266318376425476
and25823598013151109168
antibiotic6243748013151109142165225248307340363412
resistance1061374801314193135156196231282341390442
patterns15283748013170121154191243275335375
of1928374801316796
bacterial20493748013170121170207259291315364387
strains2460374801315085118169191250290
in624389801312381
urine.729389801315889112169223240
Objective:7744043013580148179239291335364423481508
Antimicrobial13244048013166128162186279303354388448511536587612
resistance19624048013151106149172214251304365416470
(AMR)24584048013148115204262292
has6244198013159108147
become7964198013160115164220310363
a11834198013150
global1257419801316082140200250273
concern.15544198013149105163212263294353372
However19504198013170128206259307359390
there2365419801313492145176228
are2617419801315081133
significant624434801314265126186209236263314365425459
differences1108434801317093124154208241295355405458500
with16344348013190114148209
regard1868434801314295158209241302
to21954348013143102
local2322434801313393144196219
epi‑25674348013163125149183
demiological6244498013160113202224281304362423444493542565
factors1213449801313686135171227259300
across15374498013157105137193233273
continents,18344498013156112171203225282335393425467485
countries23434498013156112170228260291314367407
and6244648013151109170
even8194648013162112164223
medical10674648013199154215237287337360
facilities.1452464801313789138161183205239262315356376
Local18534648013158116166217240
assessment2118464801315899140194235275365419478511
of2653464801316897
antimicrobial6244798013149106138159247268316346402462484531553
resistance1200479801312979119140178212261318365416
development16394798013156108156207229286345434486543575
is2237479801311957
one23184798013154112164
of2505479801315482
the2611479801313087139
essential624494801315393133185243274296344366
tools1014494801313086144167206
in1244494801311976
the1344494801313088140
fight1508494801312349108166197
against17294948013146105154175232271306
the2058494801313188141
AMR22234948013160145200
spread.2446494801313896128179227286304
The6245098013150108159
aim806509801314565151
of980509801315380
our10835098013153109139
work12455098013173129159204
is1472509801311855
to1550509801312983
evaluate1656509801314895143164219266297346
the2025509801312885136
occurrence21845098013153100145201231261311367414463
of2670509801315380
resistant624524801313284124145184219269326358
urinary1006524801315889111169218249301
strains,1331524801314074106156178235275293
analyze16485248013149107156178226273324
the1996524801313391144
development21645248013159112161212235293353443496554586
of624539801315987
resistance735539801313890130151190225274332381432
and11915398013156113173
compare13885398013155111200260310341393
AMR18055398013170155210
in2039539801312987
intensive2150539801312886118169227266287337388
care25625398013155105136188
units6245548013158116138171213
(ICU)861554801312951113180208
with10935548013179102135193
standard1310554801314176126183243292323381
department17155548013160113172222253291380433491523
of2262554801315887
urology.2373554801315890146169227287336349
Materials7745694013591147185241280308363391437
and12335694013554117180
methods:14365694013591148187249311376421446
We19065698013188138
analysed20685698013148106155177225265318379
bacte‑24715698013158108157193244279
rial624584801313356105127
antibiotic7765848013158117149172232255313346369418
resistance1218584801314193134156195230281339388440
patterns16825848013170120153190242274333373
of2080584801316796
urinary2200584801316799122180230262314
tract2539584801314274125174211
strains624599801314176108158180238278
in926599801313189
our10405998013166125156
medical12215998013198152212235283333356
facility1601599801313788137159181203236288
between19135998013169124157239292346404
the23415998013143101155
years25205998013157109157189230
2013–2020.6246148013153103150193247293343392442459
We11066148013185134
assessed1263614801314584123174214252304363
the1649614801313086138
susceptibility1810614801313792130177227285317338396418439460492542
of2375614801315481
bacte‑24806148013155104151187236270
rial624629801313253100121
strains768629801313669100148169224262
to1053629801312983
the1159629801312986137
different1319629801315475103132182213262318349
antibiotics16916298013145100131152210231287318339386426
and21406298013144100158
compared2321629801314498185243291321371429
the624644801313492145
resistance793644801314192133154193228277335384435
patterns12526448013169119151187238270329368
in1644644801313189
ICU-s1757644801313193161195235
with20166448013188110144202
our22426448013166124156
depart‑24226448013168121180230262299328
ment6246598013189141198229
of877659801315482
urology.982659801315484140163220279326339
We13456598013185134
assessed1503659801314584123175215254306365
the1892659801312986139
increase2054659801311975123154204252291343
in2420659801311975
num‑25196598013154110198231
ber6246748013160113144
of791674801315482
resistant896674801312879118139177211259316347
strains1267674801313670101150171227266
acting1556674801314694129150207265
via1845674801314567114
enzymatic19836748013148105149199288336368389436
modifi‑24436748013185142201223248274307
cation624689801314997129150207265
of912689801315482
antibiotics10176898013146102133155213235292324345393433
during14746898013155111142164220279
this1776689801313087108146
period.19466898013156109139161218277296
Namely22656898013166114201254276323
the2611689801313087139
Extented6247048013151101137188246278329389
Spectrum10377048013151110164213249281339428
Beta-lactamase14897048013155109142191225249297346382432521570609662
strains2176704801314075106156178236275
(ESBL),2475704801312978130183231259275
Beta-lactamase6247198013157113148200235261312363401453545596638694
AmpC13447198013176169231297
strains,1667719801315389123175199259300320
carbapenemase20137198013161113146209261323380440496589640682737
producing624734801316092148208265313335392451
Enterobacteriaceae10997348013147104136187218274334383432468518549572620668719766819
(CPE),1942734801312584137186215230
Vancomycinresistant2196734801315299156205260349395442464521624749801313283122143181215263320351
Enterococci9987498013147104135185215271319374423468489
(VRE)1511749801312582138188216
and17517498013145102160
Methicillin-resistant19357498013180132165222243290311333354375431464496547586607645679727784815
Staphylococcus624764801314877129184240282303357403455501544598633
aureus12777648013155110140184239274
(MRSA).15757648013129112166218280308323
Results:3126892013765123172236266307356384
Overall3530898013174126179211262286308
353863898013152103
8313991898013152104152
positive4168898013159119160183217240290343
bacterial4537898013158109159196248281305354377
cul‑4940898013147105128163
tures2977104801313493125178219
were32211048013186139171224
assessed.3470104801315697138192233274328390410
We39051048013196147
detected40771048013166120154206257294346407
411445101048013159106147195
resistant4730104801313891132155195231281340373
strains2976119801314280114167192253295
altogether3297119801316286122182246302338399456490
(11.53813119801314091135149206
%).40461198013193121138
Among42111198013176169231293356
them45941198013145106163256
ESBL48771198013162117173225
strains2976134801314177110161183242283
were32841348013186139172224
the35341348013141100154
most37131348013197157198233
frequent3972134801313569122183241295354387
(7.8438513480131368997153
%),45631348013188114131
with47191348013186110145204
the49481348013141100154
resistance2976149801313283123145183218267325373423
nearly34241498013154107155186209257
doubled37051498013156114171230253306366
between40951498013156110143224276329386
201345061498013149101148192
and47231498013146103162
201549091498013150101148193
(5.62976164801313083101157
%31601648013192
and32781648013160120182
10.334861648013165114134190
%,37021648013192113
respectively).3841164801314397139201258310348372424478502553581598
The44651648013196158214
adopted47051648013160122183246281334397
preventive2976179801316092144192244302334356406457
measures34581798013186139187227283314366406
have38891798013155104151203
led4116179801312073133
to4274179801313086
reduction4384179801312981141198247283305363421
of4830179801315483
sus‑4937179801313894134165
tained2976194801313383105162215275
growth3275194801315688144222259316
of3616194801315483
resistance,3723194801312980121142181216265323371422439
however41861948013155113191243291343375
the4585194801313088141
odds47501948013155115174213
for4988194801312582114
the2976209801313492146
occurrence31472098013155106153211243276328386436487
of3659209801315584
resistance3768209801313082123145185220270328378429
remain4222209801313082171221243301
higher4548209801315679138197250282
in4855209801312078
the4958209801313190144
following2976224801312986110133191270294352412
years3412224801314698147179221
in3658224801312078
comparison37612248013146102192253303335359398457516
with43022248013176100134192
201345192248013151103151197
(maxOR:47412248013126112162210285341361
1.93,2976239801315366117166184
9531842398013150102
%33102398013178
CI;341223980131598199
1.64-2.27).3535239801315063117173207254272327377406422
The39812398013148108161
increase4166239801312078126158210258298351
in4542239801311977
VRE46432398013153109160
strains4828239801313772104154177234274
during29762548013160118150174233293
the32942548013142101155
last3474254801313181122158
336572548013161
years37432548013156109158191233
and40012548013158116177
in4203254801313189
CPE43182548013170124174
strains4518254801314884117168191249290
in4833254801313189
the49472548013142101155
last2976269801312474116152
year31542698013158112162195
(0.33374269801313992111167
%)35672698013191118
may371126980131100151199
jeopardize3936269801313387148211262295355379424478
the44392698013144104159
efficacy4624269801316392120148199250301354
of5003269801316999
one29762848013158116169
of3169284801315584
the3277284801313088141
last3443284801312068108143
groups3610284801315687144201261301
of3935284801315584
antibiotics.40432848013146104136158217240298330352401442462
Antimicrobial45292848013161119151173261283331363419479502550573
resistance2976299801313285126148188224275333383435
namely34362998013156106196250274322
to3784299801313188
beta-lactam38972998013158113147198232257306356393444534
antibiotics44562998013147106139162222246304338361410453
was49342998013177127168
significantly2976314801314062120177199225251299349406438460508
higher3508314801315577135192245276
in3808314801312077
ICU-s3909314801312081148181222
compared41553148013145100189248297328380439
to4618314801313186
standard4728314801313772121178237286317374
wards29763298013179130163222262
(p3263329801313092
<33803298013167
0.00).3472329801315574128184212228
Conclusion:31263443013566128193244273337384413477542567
Our37263448013176136168
data39203448013169120153205
demonstrate41503448013170124216276336377413446498531584
the47593448013144103158
de‑49423448013170125161
velopment29763598013151104128187249341396456488
of3490359801316897
AMR.36123598013174162218240
At38773598013174107
least4009359801313286136177213
one42473598013168128183
out44553598013168127162
of4642359801316898
ten4765359801314395155
pa‑49453598013170122157
tients2976374801313456108165197238
treated3238374801313061112160192243302
for3564374801312582114
urinary3701374801315586108165213244296
tract4021374801313061111159195
infection4240374801311976103155204240262319377
(UTI)4641374801312592143167194
in4859374801311976
our49593748013155112143
medical29763898013189141200221269317339
facility3338389801312574122143164185217268
suffers3629389801313692120150201231271
fromUTI3924389801312456112200287338361
caused4308389801314594150188240299
by46303898013156103
resistant4756389801312878118138176210259315346
strains.2976404801314176107157179237276295
Occurrence32964048013177126173230261294345403452502
of3823404801316190
new39374048013162115194
types4155404801313789150204244
of4423404801316290
antimicrobial45374048013154111143165254276324355412472495543565
resistance2976419801313284124145184219269326375426
previously3426419801315890141190213271329368390438
not38884198013156114147
observed40594198013155116156209240293345405
in4488419801312078
our45904198013156114145
medical47594198013187140201223271321343
facility2976434801312979128150172193227278
is3278434801312362
a33644348013150
serious3438434801314194126148206264303
threat.3765434801313492123175223255274
KEY29784634014770134206
WORDS321046340147106190261346409
Antimicrobial29764798013166125158181272295345377435497521570593
resistance,3595479801314194136158198234285344394447464
ESBL,40844798013161114168218239
AmpC,43484798013174165227292311
CPE,46844798013173128178197
VRE,49064798013166124176196
MRSA.29764948013186140192254275
………297652340147120240360
ÚVOD29785658018197183286388
Účinná29765998013170119141200260310
terapie3311599801314396128180241264318
infekcí3654599801313291120174221270292
včetně39715998013159108160194254309
infekcí4305599801313291120173221269292
močových462259980131100160211268318372421480
cest29766148013149100140175
se3175614801313993
stává3292614801313974124171221
stále3537614801314074124146199
obtížnější.37606148013157117150172216275328349388410428
Problém4212614801315484141201224277366
antibiotické46026148013149107138161220243300333355403448500
rezistence2976629801313387133157197234286346397450
může345162980131101160206259
dle3735629801317093148
některých39096298013169123171209262295349398458
predikcí43926298013171104158220243290339362
vést47796298013160114156192
až49966298013160106
ke2976644801314799
globální3099644801316991149210260283341363
krizi3486644801315589112156179
s36896448013149
potenciálem37636448013169129161213271320342391413467556
zlikvidovat434464480131527697143196219279337386436469
zdraví48376448013153112143193241265
celosvětové2976659801314898120177216265316348402450500
populace.35006598013156113173229251298346396412
Některé39356598013166117161197247277328
předpovědi4286659801315687137196255312360410469490
dokon‑47996598013155112157213270303
ce29766748013149100
uvádějí,31006748013166115165224277299320338
že34626748013152103
do35896748013168126
roku3739674801313996142200
205039636748013161113164216
se42036748013148101
infekce4329674801313087115167213260311
může46646748013197154198249
stát4937674801314983133165
hlavní2976689801315880127174232253
příčinou3252689801315687109155176233290346
úmrtí36226898013153141171207229
ve3874689801314596
světě.3993689801313786137169219235
Problémem4251689801315180136195217269356408496
nebude47706898013154106165222280332
jen2976704801312476134
léčba3134704801312982131190240
vlastní3398704801315579127167201260281
infekce,3703704801312986114166212259310327
ale4054704801315577130
například42087048013164113173205227275299347407
schopnost4639704801314695153211271330388428463
podstoupit29767198013160118177215249304361419441473
dnes34737198013155111163203
zcela3699719801314086135157205
běžný39277198013156109152209254
operační42057198013154113166196245292349370
výkon,4598719801314596142197255272
který4893719801314278128159209
může29767348013189145187237
být32377348013155101138
v33987348013145
budoucnu34667348013156113171228284332388444
bez39337348013156109152
účinné41097348013153100121177234286
antibiotické44187348013145101132154212233290321343390434484
pro‑4926734801315586142176
fylaxe2976749801312981105153201252
pro3252749801316193149
řadu3425749801313282142199
pacientů36487498013160110159180233291322380
fatální.4052749801312879111161183240262280
Již4357749801313759102
v44837498013150
dnešní45577498013159117170210268289
době48707498013160118178232
byly29767648013161108131179
ve31797648013155107
světě3310764801314696148181231
zaznamenány35667648013149100144203252341394452501558604
zcela4194764801315097148170219
rezistentní4437764801313789133156195229280338370428450
bak‑49117648013166116161191