593
30223226014562121
Ces8507936014570127174
Urol10497936014578115180208
2023;12827936014562121178238260
27(1):15677936014562119147202226248
29–3518407936014562121184242300
ORIGINÁLNÍ852207016996181224324367468561635735777
PRÁCE1667207016983165262348424
kantní850898013147100159192252275
rozdíl115089801314199143203225251
(p1426898013138100
=1551898013175
0,995)165189801316482133188242270
mezi19468980131100155201224
BMI2195898013165152175
a2395898013160
agresivitou2480898013159120153206247269320344378436496
karcinomu850104801314797129175197255313403460
prostaty.1334104801316092148188223273305356369
Při1728104801315484107
hodnocení18591048013158117177235293343393451473
pooperačního23561048013160119178239293324374422480502562620
stagingu850119801314278130191214274335394
byl12701198013170119144
častější14391198013159110152188240263304326
klinicky1791119801315681104164187237284337
pokročilý21531198013171133181215274325348371421
KP25991198013165123
(pT3)27471198013138101146203229
stadium850134801314176125185206263352
u12261348013159
pacientů13091348013161110159181233291323381
s17141348013141
BMI17791348013155140162
nad19651348013159108168
3021571348013153106
(p2287134801312989
=24001348013166
0,100).2490134801315471117164219246261
Závěr:10001493013562119173228268294
Ačkoliv13191498013173120165222245267316
v16591498013158
České17421498013170122162207259
rebublice2025149801314192152211270293315364415
je2464149801313184
procento25721498013169101158208259317349405
obézních8501648013158116169212269290337393
pacientů12661648013156104151172223280311367
nemalé,16561648013154105192240261312328
nepotvrdili20071648013154106164222253304335392413434454
jsme2484164801311957144195
jasnou2703164801311865104160217273
souvislost850179801314199157207229268290348388423
mezi12971798013196149193216
agresivním15371798013156115146198238259309368389478
karcinomem20391798013152103134181203260319408462551
prostaty2614179801316698155195229279311362
a8501948013150
obezitou.9241948013159119173217240273329387406
KLÍČOVÁ8522234014770132164236320392464
SLOVA13422234014763124208280352
Obezita,8502398013176139196242266301353373
nadváha,12482398013170121183234287347398418
agresivní16912398013160122155209251274325387410
karcinom21262398013157110143192215275336429
prostaty,25802398013172105164206243294328382396
radikální850254801313282142164209260282339361
prostatektomie.1235254801316193149189224274306357402439495585607659676
SUMMARY8522834014762143243345423493561
Hartmann10002998013169118149186276325383440
I,1464299801312442
Král1530299801315588138161
M,17152998013185105
Kudláčková18442998013155111171193241290335392440490
Š.2358299801315168
Obesity24502998013174134188229250283335
and28092998013150108167
risk85031480131325594139
of1013314801315987
prostate1124314801316193149189224274306357
cancer.1505314801314999156205256287301
Aim:10003293013572101197223
Obesity,12563298013176139195237259294348362
as16433298013160102
one17703298013169129185
of1980329801316999
the21043298013144104159
most228832980131102162204240
common25543298013159117209301362423
diseases850344801315980118169216255306345
of1219344801315380
civilization,1323344801314464112134155176218268299320376433451
which17973448013174131152199255
has20753448013154101140
a22383448013145
huge23063448013154109167219
impact25483448013118105163212259294
on28653448013154111
the850359801313492145
overall10193598013155103155186236258280
health13233598013155108156178212269
status1617359801313771121153211250
of1891359801315583
the1998359801313189142
population.21643598013157116176234256305337359416475493
The26813598013148108161
in‑2866359801311977110
creased850374801314878128174213264322
morbidity11953748013184141172230251309329361411
and16293748013145100158
mortality18103748013184141171207255276296328378
of2211374801315380
obese23143748013153111164202254
patienets25913748013155103134155206262313345385
is850389801312360
due9333898013155110161
to1117389801312984
obesity12243898013153111164202223255304
itself155138980131195191142164191
and17653898013145101158
also1946389801314566104160
due21293898013155110161
to2313389801312984
the2420389801312985136
increased2579389801311975122152202248287338397
incidence850404801312379126147205256312360409
of1282404801315481
diseases1386404801315576114166212251303342
that1751404801312986133164
are1938404801314576126
not20874048013154111142
directly2252404801315576106156204239261308
related258340480131277899147178227286
to2892404801313084
obesity,8504198013159119173213234268319332
and12064198013146104164
yet1394419801314597130
their1548419801313088141163194
occurrence17664198013155105151209240272324382430481
is2271419801312059
more23544198013186145177228
frequent2606419801312659110170227280338370
in850434801312382
obese9574348013168129184226280
patients.12624348013170121154176230289322364385
Our16724348013183143175
aim1872434801315981171
was20684348013189140181
to22734348013143100
demonstrate23984348013169123214274333374409442493526578
this850449801313594117157
association10324498013159100141201252274324357380439499
in1556449801313291
obese16724498013168130185227281
patients19784498013170122155178232291324367
with23704498013189113147206
prostate26014498013171104162203239290323375
cancer,8504648013150101161211264296310
which11864648013189150172222282
could14934648013158116176199260
lead1778464801313287136198
tothe20014648013143101134194249
modification227546480131101161223246273300350402435458518578
of2878464801316898
recommendations850479801313385135192282372426484544594626649707766806
regarding1681479801314193154203235293316374434
the21394798013143101155
early23194798013162110142165214
diagnosis2557479801316991140200258317358379419
of850494801315987
prostate961494801316193149189224273306357
cancer.1342494801314998156205256287301
Material10005093013591147185240279307362390
andmethods:14135093013552114178290347386448510574619644
we20825098013176128
evaluated2234509801314998148170226275307358418
a26765098013146
set2746509801313891124
of2894509801315483
2008505248013154105160
patients10345248013157107139161214272304345
who14035248013176135193
underwent16205248013155112172225256338390448480
robotic2124524801312985145205237259307
radical2455524801312979139160209258280
pros‑2760524801315789145185216
tatectomy850539801313482114164213248304392437
for1311539801312581112
prostate1447539801315687143182216265297347
cancer1817539801314594151199249279
between21205398013156109142222274327384
December25275398013167120168218306365418449
20178505548013154105153197
and10715548013152110169
April12645548013167127159182203
2019.14925548013156107155200215
Age,17315548013167125178195
preoperative1950554801316395147206266320351401433456505557
PSA25315548013157107169
(pros‑2724554801313292124181221252
tatic850569801313483115137185
specific1058569801313796150199220246272321
antigen),14025698013146104135157216268325350366
prostate1791569801315789145184219268300350
volume,21655698013146102125182270323339
BMI25285698013152136158
(27105698013125
Body27595698013151109169217
Mass8505848013186135174214
Index1088584801312077137190237
),1349584801312641
positive14145848013157117156178211233282334
family1772584801312576165186208256
history,2052584801315677116151206238290303
postoperative23795848013157116156191247307361392442474496545597
stage850599801314176125185237
according11125998013155104150206238296318376435
to1571599801314096
TNM16915998013157128212
classification,1927599801315577126166206227253279328378410432490548566
and25175998013156114173
risk2714599801313961100145
of2883599801316593
aggressive8506148013150109169200252292332353402454
prostate1328614801316698154194229278311362
cancer17146148013154103161210261292
according20306148013155104150206238296318375435
to2489614801313995
ISUP2608614801312877143197
(In‑2829614801313456113147
ternational850629801313485116174223254276334392440462
Society13366298013147105154176228261312
of1672629801315483
Urological1778629801316596152175233293314362411433
pathology)22356298013157107139196254277335395443469
grade2728629801315687137196248
group850644801316091148206265
were11396448013180132163215
evaluated13786448013153102152174231280312363423
in1825644801312381
these1930644801313492145185238
patients.21926448013161111143165218276307349369
Results:10006593013564121167229257295341366
In1391659801313089
our15036598013167126157
group,1684659801316899156214274291
3419986598013162116
%21386598013190
of2252659801316795
patients23716598013169119151173226284316358
were27536598013188140172223
overweight8506748013159106156187268319340398454485
(BMI1358674801312982166187
25–30)15686748013153105159207258284
and18756748013150106165
5220636748013153102
%21886748013181
of2292674801315986
patients24016748013160109140161213270300341
were27656748013179130161211
obese8506898013159118171210262
(BMI1135689801313084167188
>13466898013167
30).14366898013156107133147
In1606689801312481
patients17106898013162111142163214271302343
with20766898013180102134191
BMI22906898013157141162
over24756898013160107158188
30,26866898013155107123
the2832689801313592144
volume8507048013150106128183271323
of1196704801315481
the1300704801312986138
prostate1461704801315687142181215263294344
was18287048013174123162
statistically2013704801313669118149170207241262309357379399446
significantly2482704801313656114171191216243290339395426447494
greater850719801316090140187218268299
than1172719801313794142199
in1394719801312683
the1500719801313794146
group1669719801316494149206264
with19567198013183105137194
BMI21737198013159143164
<3023607198013169120171
(p=0.034).2554719801313392158214230282331384408422
We8507348013189136
didn´t1008734801315473130185208236
confirm1266734801314396152175202230317
the1605734801312883134
relationship176173480131277596142172192247303340395414471
between22547348013154106137215265316371
BMI26477348013149131151
and2820734801314499156
PSA8507498013155104165
level1037749801311971118169190
(p=0.944).1250749801312483149204221270323378402416
Furthermore,16897498013146100130166223274305393450481531547
we22597498013174125
evaluated2407749801314896144165221269300349408
the2838749801312986138
relationship850764801313383105153184205262320359415436495
between13687648013168121153234286339396
BMI17877648013163147168
and19797648013157114172
cancer21757648013156105162210260290
aggressive‑24887648013158116175205256295334355403454488
ness.3203898013161115156196216
We34438980131100151
didn´t361889801316991152211237267
confirm3909898013158115175200228259351
a4285898013158
statistically436889801314984135168190229264287336386409431480
significant487289801315071131190212238266315366425457
difference3203104801316081109138189220270327374424
(p=0,995)3650104801313594160215231280333383409
between40821048013166119151232283335392
BMI44971048013161145166
and46861048013155112170
aggressive48791048013156114172202253292331351399450
prostate3203119801316294152192227278310362
cancer.35891198013158108167216267299313
When392611980131100160214273
evaluating42231198013162111162184242291324346404465
postoperative47121198013169130170205262323378409460493515565617
staging,3203134801314174123181202258317334
locally3560134801312683132180201222269
advanced38521348013153111159208265312362421
prostate4296134801316495150189223271302352
carcinoma46711348013152101131177197254311400447
(pT35141134801313392134188
stage)3203149801314175124183235260
was34861498013187136175
more36841498013198155187237
common39451498013156111200289347405
in4373149801313087
patients44831498013168117149170222279310351
with48581498013186108141198
a50791498013158
BMI51601498013163147169
over32031648013159106156187
3034131648013152103
(p=0,100).3539164801312888154209225270316370396410
Conclusion:33531793013563122182230257317360387446507531
Although3907179801315879110166223279336392
the4321179801312985136
percentage44801798013154106136181230286316364421472
of4975179801315279
obese50771798013152111163201252
patients32031948013162114148171226286319362
in3591194801313292
the37081948013143104159
Czech38921948013173121175226286
Republic42031948013166121183243305329352402
is4630194801313273
considerable,47281948013159117178219242303358391442504529583601
we32032098013181135
didn´t3363209801317093154213240271
confirm36592098013159116177203231263355
a40392098013160
clear4124209801315982136186218
connection43682098013158116176236291342379402462522
between49152098013171127161245299354414
aggressive32032248013150109169200252292332353402454
prostate3681224801316193149189224273306357
cancer4062224801314998156205256287
and43732248013150108167
obesity.45642248013159119173213235268319333
KEY32042534014770134206
WORDS343625340147106190261346409
Obesity,32032698013174136190231253287338352
overweight,35792698013167116169200283336358418476509528
aggressive41312698013159119179211263304344366415468
prostate46232698013170102159200235285317369
cancer,50172698013157107166215266298312
radical3203284801313282142164212262284
prostatectomy.3511284801316193149189224273306357406442498588634647
………320331340147120240360
ÚVOD32053558018197183286388
Odhaduje32033898013174134191240299356378430
se,3657389801313790106
že3787389801314192
cca3903389801314591140
3040673898013150102
%41933898013177
populace42943898013157116176233255304352403
v47213898013145
USA47903898013165113175
je4989389801311972
obéz‑50853898013154114168212244
ní.320340480131598199
V33264048013159
České34094048013165116156201253
republice3686404801313587147205264287309357408
je4118404801312679
udáváno42214048013161121169217267325383
obézních46284048013161121175220279300348406
kolem50584048013149106129182271
2032034198013154105
%33324198013181
mužů34374198013189146190248
a37094198013149
1837824198013153100
%39064198013180
žen4010419801314495153
(1).418741980131287696111
Obezita43224198013173134188232255288338
je4684419801312375
svázána4783419801314191141185236294343
s51504198013140
řa‑5214419801313282115
dou32034348013159116173
nádorových34004348013154102161218249305352403450507
onemocnění39304348013154112164252309358415467523544
např.44984348013154102161192203
kolorektálního4724434801314298121178209260305341389411468489548605
karcinomu3203449801314697128175197254312401458
nebo36854498013156109168227
nádoru39364498013155104163221253311
prsu4271449801315789130186
žen4481449801314192150
po46554498013157116
menopauze.47954498013186139197255315365422466517534
Vztah32034648013156100137186244
mezi34714648013194148192215
obezitou37104648013162123177221244277333391
a41254648013154
karcinomem42034648013151101133179201259317407460549
prostaty4776464801316597153193228277309361
(KP)5161464801313386142168
je3203479801312476
méně33034798013192145203256
jasný3583479801312573113170216
(2).3824479801313082108123
Ačkoliv39714798013166113158214238259308
mnoho43034798013192150208267325
studií4652479801314377135194216238
potvrdilo,49144798013162121154206238296318340398415
že3203494801314597
zvýšený33244948013153106159200254312359
BMI37074948013164150173
je3904494801313285
spojen40144948013149109169192245304
s43424948013150
vysoce44164948013158111152211261313
rizikovým4753494801314164108131177234283336427
KP,52054948013163120124
jiné3203509801312445103156
toto3383509801313490122178
nepotvrdily35865098013159112171231263315348406427449497
či4107509801315071
poukázaly42025098013161120178224274319370392440
spíše46665098013141100123165218
na49085098013159108
inverz‑5040509801312380128179211257289
ní3203524801316083
vztah.33115248013160108146198258278
Ve36145248013166117
studiích,3756524801315187146208231253303363382
kdy41635248013156116166
byl43555248013170119144
prokázán45245248013171104162210263309362422
inverzní4971524801313291140194227275335358
vztah,3203539801315096133183241259
bylo34865398013161108131189
poukazováno36995398013161120178223274319375423473531589
na43125398013159108
větší44445398013150101134176197
objem46655398013159119142194283
prostaty4972539801316193149189224274306357
u32035548013158
obézních32855548013155116170214273294342400
mužů37095548013186144188245
a39785548013147
z40495548013140
toho4113554801313187145204
plynoucí4341554801315780128187245303352373
obtížnější47385548013155115148170214273325347386407
dia‑5170554801315678126159
gnostiku32035698013160117175215250272317374
karcinomu3601569801314394125172193251309398455
(3–6).4080569801312576131188214229
Mezi43335698013182135179202
rizikové455956980131285194117162219267318
faktory4901569801312576121158214245297
KP52225698013151107
patří32035848013161110142174196
rodinná3423584801312985145167224282330
anamnéza,37775848013146104152241299352396446465
záněty4266584801314091148201234285
a45755848013146
infekce,4645584801311976104156201248299316
sexuální4984584801313891138196244266323345
aktivita/sexuálně3203599801315095132154203226259309349385438485543592614671724
přenosné3951599801315789140198256296354407
choroby,43825998013145103161193249309357370
kouření,4776599801314299157188239297319337
diet‑5137599801315678130163192
ní3203614801315981
zvyklosti,33086148013153106159206230288329363386404
a37366148013158
s38196148013149
tím3892614801314265154
související40706148013150108167216239279332354376424446
obezita.45416148013167127182227249283333352
Normální49186148013178137169260309331389411
hodnota32036298013159117178235294326376
BMI36036298013160144167
se3794629801314699
pohybuje39176298013165124183229290348370423
od43646298013163123
18,545116298013159105123177
do47126298013164122
25.48586298013159112128
Nad50116298013174123183
2552186298013158111
mluvíme32036448013191114173223247337392
o36196448013168
nadváze37126448013168118179229280326378
a41156448013159
nad41996448013168118179
3044026448013163117
pak45446448013169120167
o47366448013168
obezitě.48286448013168130185230254288340358
Při5210644801316596119
hodnotě32036598013159117178235294326377
3536046598013161111
a37396598013157
víc3821659801315780128
pak39736598013168118163
již416165980131315296
jde4281659801313190143
o44486598013166
obezitu45396598013166126180224247280338
morbidní.49016598013198156188249271330388410428
Jako3203674801313886132189
příčiny3416674801315788111158180237283
obezity37246748013154115169213236269320
jsou4068674801312059117175
uváděny42676748013155104154213266324370
až4661674801314690
v47756748013146
6048456748013150104
%49736748013178
gene‑50756748013156109167220254
tické3203689801313456104150201
dispozice,3428689801316688127186245288310359409426
dále38786898013166115137190
pak40926898013167117162
nepoměr42786898013165118178237327380411
mezi47136898013196149194217
příjmem4954689801316698121144233286375
a32037048013150
výdejem3277704801314799157210232285374
kalorií,3675704801314495117175207229251269
hormonální39687048013156114146236295353402424482503
a44957048013148
metabolické45677048013187140173223283342365386435480532
vlivy.512370480131477091140193206
Výsledky32037198013155103143164215274318369
uváděných35957198013153102150208260316361407464
souvislostí4082719801313693149198220257279335374408429
mezi45347198013185137180202
obezitou47597198013154112165209230263317374
a51567198013145
KP52247198013150105
jsou3203734801312463122180
závislé34087348013153104152175214237290
na37227348013168117
dvou38637348013169119176235
skupinách4122734801315095154214237295344393451
vlivů.4598734801315881103153212229
Za48517348013168119
prvé49947348013169102155207
se52267348013149103
jedná3203749801312375134191238
o34657498013154
vlivy,354274980131456788136187200
které3765749801314278128159209
při3998749801315586108
obezitě41307498013153112165209231263313
ovlivňují44677498013153101123144192250305327348
diagnostiku4838749801315576124182239296335369390434491
tzv.3203764801313481134148
detekční33757648013169122155207253300358380
bias.3779764801316992141181201
Sem40047648013159113202
patří42317648013169119152184206
PSA44627648013163113176
hemodiluce46627648013168121211270330352375432481532
ve52197648013158110