602
102197226014562116174
Ces8507936014570127174
Urol10497936014578115180208
2023;12827936014562121178238260
27(2):15677936014562119147205235257
101-10818507936014561116172203256311372
PŮVODNÍ852207016974172259362464566608
PRÁCE1507207016974156253339415
dárců850898013160109140187244
s1119898013141
prokázanou118589801316092149195246290341399457515
arteriální172589801315081118169201223272294351373
hypertenzí2123898013159105166220251288339397441464
na2612898013159107
502744898013154105
%.2874898013181102
438501048013154103
dárců9841048013160108140186244
(771259104801312981134
%)14241048013181106
bylo15611048013161108131189
před1781104801316193144204
operací20171048013158118172204254302324
nekuřáky23721048013159112158216247297342394
a27971048013150
132878104801315498
dárců8501198013159106137182238
(231107119801312979130
%)12561198013180104
kouřilo.13791198013146101158188209230287304
V17021198013155
našem17761198013158105144195282
souboru2077119801314197154212270301358
se2454119801314092
souvislost2565119801314097153201223261282339378411
s8501348013141
kuřáckou9111348013147105136185234279336393
anamnézou13251348013150107156245303355400456514
a18601348013149
následnou19301348013159107147169221282339397455
funkcí2406134801312887145190237259
nativní26851348013159108140162211270291
ledviny850149801312376136186209266312
neprokázala11851498013159112171203260306357402452475523
(medián17311498013129115168228250298356
kreatininu2110149801314680131179211234291313370427
v25601498013150
526321498013154
letech2708149801312477110161210268
od8501648013159119
dárcovství9901648013160109140187243291331366418441
u14521648013159
nekuřáků15321648013159112158216247296342400
94,519531648013154108125178
umol/l,21531648013158147205228267291308
u24821648013159
kuřáků25621648013146104136185231289
8228721648013153104
umol/l).8501798013158146204226264288316330
Ve12001798013155104
sledovaném1324179801314162114174231279328385437525
období18691798013158118177235294316
bylo22051798013160107129187
potvrzeno24111798013161119151203235280331388446
182877179801315399
selhání850194801314194117174222280302
štěpu,1172194801314175126186244261
přičemž1454194801316192115163213302346
medián18211948013190143203225273331
délky21721948013160113135180231
funkce2424194801312987145190237288
štěpu2733194801314175126185243
byl8502098013161107130
6510012098013153104
měsíců11252098013190142182203251308
a14532098013150
medián15232098013190142202224272329
hladiny1873209801315880129188209267312
5letého2206209801315373126159209267325
kreatininu2551209801314780131179211233290311368425
u8502248013158
příjemců927224801316090112135186273321377
byl13232248013160106128
1211470224801315396142
umol/l.16312248013158145202225262285303
V19532248013155
sedmi2027224801314192151238259
případech2306224801315990112170219277328377433
(132758224801312975119
%28962248013180
příjemců)850239801316192115138191280329386411
zemřel1288239801314596185216267290
recipient1605239801313384134155215237290348380
s20122398013141
funkčním2080239801312887145191237295317406
štěpem2513239801314175126185239328
na28692398013158107
jinou850254801312445103161219
závažnou1093254801314495143193237296354412
komorbiditu.15292548013146103193251283344366425447480538557
Závěr:10002693013561116168221259284
Transplantace1303269801315074122178216273295342398428476523572
ledviny1894269801312273132179201257301
od22142698013157116
žijícího234826980131446585106152173231287
dárce26542698013159106136181230
je2902269801312374
vysoce8502848013149101141198247297
efektivní1167284801315280131176213234283341362
metoda15492848013189142174229289337
léčby1906284801312375123182228
ledvinného2154284801312375135183206263320372429487
selhání,2660284801314193115172220277298316
která850299801314683134165215
má10852998013190138
ve12442998013149101
srovnání1365299801314172128176235283341362
s17482998013141
transplantací1809299801313465115173212271294342400431481529551
od23802998013158118
zemřelého2519299801314495184215266288341399457
dárce8503148013160109140187237
lepší1116314801312376136176197
úspěšnost.1342314801315898157211250308366406441460
Potenciální18313148013155111143194252300322371393450472
žijící233231480131446688110158179
dárce25403148013160109140187238
led‑2806314801312476137170
viny850329801315073130176
musí10483298013190147187208
být12783298013161108145
pečlivě14453298013161115164186207257308
vyšetřen17753298013150102142195228260311369
a21663298013150
zároveň2238329801314495127183231283341
musí26013298013190147186208
být28313298013160107145
podrobně8503448013160117176206261320377428
poučen12973448013160118174221270327
o16433448013157
možných17193448013189146187244289335391
rizicích212934480131325396118165185232288
vyplývajících2436344801314999159181228279328349370416437484540
z8503598013144
dárcovství9183598013160109140187243291332366419441
ledviny.1383359801312477137186209267313326
KLÍČOVÁ8523884014770132164236320392464
SLOVA13433884014762123207279351
Dlouhodobé850404801317195153211268327387445505559
výsledky,14324048013150102143164217278323374387
transplantace1842404801313466116174213272296344402434483532583
ledviny,2448404801312376136186208266312325
žijící279640480131446789110158180
dárci.8504198013160109140187208227
ABSTRACT8524484014776146210275345425494562
Matysková10004648013185133165215255299355403452
Kubišová14714648013155110169191229286334383
M,18734648013185104
Pacovský19974648013154102149205252292336387
J,2403464801313854
Navrátil24774648013170118165196246277299320
P28174648013154
jr.,28914648013123546785
Šafránek8504798013151101129162212269322368
R,1244479801315676
Navrátil13464798013170119166199249281303325
P,1697479801315559
Guňka17824798013169127185230281
I,2089479801312341
Dusilová21564798013171129169190212270318368
Sulková25504798013151108130175232280330
S.2906479801315170
Long-term8504948013151109170232266301354387480
follow-up1364494801313089113136196277312373435
of1833494801316090
living195749480131244698122181243
kidney2234494801314873134194249299
donors25674948013161121182242276319
–29194948013157
a8505098013150
single924509801314162120179201254
center12025098013149100158190241272
expirience.14985098013154101162184215238290348397448465
Aim:1000524301356996187212
The12315248013151109161
main14125248013189137158214
condition16465248013148103160219240273294351408
for2073524801312985116
kidney2209524801314669127183235282
transplants2510524801313465114171209267290337394425466
from850539801312962118208
a10805398013150
living115253980131244594117175234
donor14085398013160118177235267
is1697539801312362
to1781539801313490
ensure18945398013153111150207238289
the2206539801313492145
donor‘s23735398013160118176235267287325
safety2720539801314191119171205256
and8505548013150109169
exclude10525548013154102150172230290344
donation14295548013160119178228260283341400
under18625548013159118178232263
duress.21585548013161118150202243284303
The24945548013152112166
aim2693554801315073162
of2888554801315988
our8505698013159116148
work10205698013179136168214
is1256569801312362
to1340569801313490
try1452569801313465117
to1591569801313490
describe17035698013160113153202233256315369
the2094569801313492145
risks226156980131325594139182
arising2465569801315081104143164222281
from2768569801312962118208
donation8505848013159116174222254275332389
in1259584801312380
the1358584801313491143
context15215848013148103161192242289325
of1866584801315885
the1971584801313491143
current21345848013148105135167218275306
perspective,24595848013161114144185243296345380402450501517
data8505998013160109141190
from1062599801312962118208
large1291599801312472103161214
sets1527599801314194127169
of1717599801315987
donors18255998013160118177235267308
and21545998013150108168
control23435998013149105163195227284307
groups2671599801316091148206265305
and8506148013150108167
describe10416148013160113153202233256315369
our14356148013158116147
own16066148013159137196
results.1826614801313284124181203236278297
Patients10006293013561114151178233295332377
and13966293013555116179
methods:15936293013592148186248308372416441
5620546298013153104
pairs21776298013160109130161201
were23976298013179130160211
enrolled26276298013153110140196218239291350
in850644801312380
the950644801313391143
retrospective1113644801313384116147203243301355404440461510561
study.1694644801314175132191239252
The19666448013150110162
results2148644801313283123179201233275
of2442644801315987
the2549644801313391143
donor27126448013160117175233264
were8506598013179131163214
mainly10856598013190138160218240288
monitored13936598013190148207228262318349401461
–18756598013154
serum1950659801314194125183272
creatinine2243659801314980131179211233291313370423
values,26866598013150100122179232272290
the850674801313491143
occurrence10136748013157106152208239270321378426476
of1508674801315886
arterial1614674801314980116166197219266288
hypertension19216748013159104164217248284334391430451507565
or2505674801315890
diabetes2614674801316081128187240272323362
after850689801314976112162192
donation,10616898013159115172220251272328385402
the1482689801313390141
effect1642689801315381110160209243
of1904689801315885
smoking20086898013140127184229251307365
on23926898013158115
the2526689801313389141
further2686689801312886116152208260290
fate850704801312982115168
of1051704801316090
the1174704801313595150
donor13577048013161121182242275
and16667048013151110171
eventual18717048013154105158218251311361384
cause22897048013150101160201256
of2578704801316090
donor27017048013161121182242275
death.8507198013159111158189246265
In1134719801312380
the1233719801313390142
recipient,1395719801313282131152210232284340371390
serum1804719801314193123180268
creatinine2091719801314979130177208230286307363416
values2526719801314998119175227266
and28127198013149106164
possibly8507348013161120160200221280304352
the1226734801313492145
cause1395734801314999156195248
of1667734801315987
graft1778734801316091141169207
failure.2009734801312979101123180211263280
Results:10007493013564121168231260299347373
In1406749801312483
our15227498013159118151
group1706749801316093150210271
of2010749801315988
donors21317498013161121180240273315
we24797498013181134
register2646749801313386147170210245298330
408507648013154108
females981764801312981170219241294334
(71%)1338764801312982131204229
and15907648013150108167
1617807648013154100
males19037648013190139161214254
(29%).2180764801312981132214239255
The24577648013152111165
median26447648013191144204226274332
creatinine320389801314980131178210232289310367419
level364289801312476124175198
at385989801315082
53961898013153
years403489801314899147178218
after427289801315077114165196
donation4488898013159117175223255276333391
is489989801312362
934980898013154103
umol5103898013158146203226
/l.320310480131396483
None33191048013172131191245
of3598104801315988
the3720104801313494148
living390110480131244697120179240
kidney4174104801314772133192246295
donors45021048013161120180240273315
developed48501048013161115165218241300362417479
terminal3203119801313483114202224280328349
renal3571119801313383140187209
failure379911980131297899121176207257
during40761198013159115145167223281
the4377119801313390142
study4539119801314074130189236
period.47941198013160113144166222281299
Phar‑51131198013154110157188216
macologically32031348013190139188243267325385407455505527549597
compensated38201348013149105195255309366406456488539599
arterial4440134801315081118169201223272294
hypertension47551348013159105166220251288339397436457515574
occurred32031498013158106151207237268318377
in3599149801312278
29%36961498013153103183
of3898149801315785
donors40011498013159116173229260300
prior4320149801315990112168199
to4538149801313388
kidney4645149801314568126182234280
donation49441498013159115172219250271328385
and32031648013150108167
in3398164801312380
the3506164801313492145
monitored36791648013190148207229262318350401462
period41681648013161115147169227287
after4483164801315078115166198
transplanation4709164801313465115173212272295343401450482504562620
the3203179801313492145
number33711798013159116205265319350
of3744179801315987
donors38541798013160118177235267308
with41851798013179102135193
proven4401179801316193150198250308
arterial4732179801315081118169200223271294
hyper‑50491798013159105166220251280
tension3203194801313485143183204262321
increased3556194801312381130161213261301355415
to4003194801313491
50%.41261948013154105187208
4343661948013154103
donors45011948013160118177236268309
(77%)4842194801312982135214240
were51141948013180132164215
non32032098013158116173
–33952098013155
smokers34692098013141128185230281312352
before38402098013160113141197228279
surgery4138209801314196127183235266317
and44742098013150106165
134658209801315397
donors47742098013159116174231262302
(23%)5096209801312979131208233
smoked.32032248013140126183227277335353
In3574224801312379
our36712248013157113143
group,3833224801315888143199256272
the4123224801313390141
association4282224801314987125182229250296327348404460
with4761224801317899131187
smoking49662248013140126183227250306363
history3203239801315981120154210242294
and35212398013150108167
function3713239801312987145194230252310368
of4106239801315887
the4217239801313492145
native43862398013159108140162211263
kidney4674239801314670129187240288
was49862398013179129169
not51792398013159117150
proven3203254801316091146193244301
(median35232548013128113165224245292348
creatinine3890254801314979130176208229285306362414
at4323254801315081
544232548013153
years4495254801314898145176216
after4730254801314976113162193
donation49422548013159116173221252273329387
in3203269801312381
non33052698013159118176
–35032698013155
smokers35802698013141129188234286317358
94.539602698013154108126179
umol/l,41612698013159148206229268291309
in4492269801312380
smokers45942698013141130188234286317358
8249742698013154104
umol51002698013159148206229
/l).320328480131396291106
In3334284801312381
the3440284801313492145
study3611284801314175133192241
period,38772848013161115146169226287305
1842072848013154100
graft4332284801316091141169207
failures4564284801312979101123180211263303
were48922848013180132163215
con‑51322848013149105163197
firmed,320329980131265383171223282299
with35212998013179100133190
a37302998013149
median37982998013189141200221268325
graft4142299801315989138165202
function4363299801312886142190225246303360
duration47422998013159115145194225247303360
of5122299801315785
6552262998013153103
months32033148013190148207239297336
and35663148013150108167
a37603148013150
median38373148013190143204225274332
level4195314801312477125177200
of4422314801315887
545363148013153
–46163148013155
year46983148013149100149180
creatinine4905314801314980132180212234292313371424
in3203329801312381
recipients3309329801313384134155215237290348380421
of3756329801315887
1213869329801315398145
umol/l.40393298013159148206229268292310
In4375329801312380
seven4481329801314194143195253
cases4759329801314999139192232
(13%5017329801312976121200
of5242329801315987
recipients),3203344801313386137159220244298357390433458475
the3711344801313594149
recipient3893344801313386137159220244298357390
with43163448013181105139199
a45483448013151
functional4632344801312990149199236259319379429452
graft5117344801316193145173212
died3203359801316082134195
from3422359801312861118208
another36543598013150107166198256309340
serious4019359801314194125148205263303
comorbidity.43463598013149105194253285345368427449482533547
Conclusion:33533743013564125187236264326371399460522547
Kidney3920374801315578137195248295
transplantation4235374801313466115173212271294342400431481513535592650
from4905374801312962118208
a51333748013150
liv‑520337480131234493126
ing3203389801312381140
donor33673898013160118176234266
is3657389801312362
a37433898013150
highly3817389801315981140197220268
effective4108389801315483112164214250272321373
method45053898013190143176235293353
of4882389801315887
treating4993389801313466117165197219277336
renal3203404801313284142191213
failure,3439404801312980101123180212263280
which37424048013180138160208266
has40314048013159108148
a42024048013150
better42754048013161115148184235267
success4565404801314198146193243284323
rate4912404801313282114165
com‑51014048013149105194228
pared32034198013161111142193254
to3486419801313490
transplantation3605419801313466116174213272296344402434483515538595654
from4288419801312962118208
a45254198013150
deceased46054198013160113162213261301354414
donor.50484198013160118177235267281
A32034348013164
potential32954348013160120152203261293315363385
living370843480131234494117174233
kidney3969434801314670129187240288
donor42844348013160118177235267
must45784348013190148187221
be48274348013160114
carefully4969434801314999130181210268291312360
investigated3203449801312379125176215248270328375406456515
and37374498013150106164
given3920449801316081129179236
detailed41754498013159111143191212234285344
information4538449801312379106162193281329360382438495
on50524498013158115
the5187449801313390142
potential32034648013161120152203261293315363386
risks361346480131325594139182
arising3819464801315082104143164222281
from4125464801312861118207
kidney4357464801314670129187240288
donation.46694648013159118176225257279337395414
KEY32044934014770134206
WORDS343749340147105189260345408
Long-term32035098013150108168228262296348380472
results,3708509801313386127184207241284303
kidney4044509801314772132191245294
transplantation,4371509801313467118177217277301351410442493526549608667686
living509050980131244696120178239
donors.32035248013160118176235267308327
………320355340147120240360
ÚVOD32055958018197183286388
Transplantace3203629801315177128187227288312361420453504554606
ledviny3839629801312478139190214272319
od41896298013159120
žijících434062980131446891113163185234293
dárců46646298013160110142190248
jsou4943629801312464123182
jed‑5156629801312477139173
nou32036448013159119179
z34176448013144
metod34966448013191146180238300
léčby3831644801312378129190239
nezvratného41046448013160114161215249301334394449509569
selhání4708644801314196120179229289312
ledvin5055644801312378140191215274
a32036598013149
nabízejí32746598013158107166189233285307329
příjemci3625659801316092114138191279328350
největší39976598013158111134183234268309331
šanci4350659801314090148197219
na45906598013158107
nejdelší47196598013158111133192245268307329
funkci5070659801312887145190237259
transplantovaného3203674801313365114171210268291339396427483530579636689746803
orgánu4027674801315789146194251307
(1).435467480131297696111
Důležitým44856748013170127149201244267300350439
faktorem4944674801312978123160215247297385
je3203689801312477
možnost33066898013190149193252312353389
preemptivního3720689801316194146201291352386409459519542603663
provedení4408689801316194152201254315369428451
transplan‑4884689801313467118177217278302352411445
tace.3203704801313485134186205
V34347048013156
případě3516704801316093117177228289343
preemptivní3885704801316093146201291352386409459519542
transplantace4453704801313467118177217277302351410443494543595
je5074704801312478
pří‑5178704801316093117151
jemce3203719801312479172223277
obvykle35167198013160123174229278304360
v39127198013151
dobrém39987198013162123186220274367
klinickém440171980131477497158182233280335427
stavu,4864719801314279132182243263
bez51637198013162119166
uremických3203734801316094148241265316364419469530
symptomů,3769734801314294189251287346439499519
a43247348013151
není44117348013161117178202
vystaven46497348013151106149186239289344405
riziku5090734801313358105130178239
vzniku32037498013151102165189238301
komplikací35477498013148109204268294319368422475500
doprovázejících40917498013161124188223284336390438494519544596620672734
dialyzační4869749801316287139164216266321373435460
léčbu.3203764801312377128188247267
Zároveň35027648013159110143200250302361
odpadá38957648013159120181232292342
i42697648013123
nutnost43247648013159117151211270311347
založení4703764801314496119178222274333356
dialy‑5091764801316083132155204238