611
106194226014562116178
Ces8507936014570127174
Urol10497936014578115180208
2024;12827936014562121178235258
28(2):15657936014562121154212242264
105–11218557936014561116176237290338390
ORIGINÁLNÍ852207016996181224324367468561635735777
PRÁCE1676207016974156253339415
v850898013150
OS930898013174123
(p108389801313090
=1203898013166
0,72),129989801315471123175201217
DSS1546898013171120169
(p174589801313090
=1865898013166
0,75),196189801315471123172199215
PFS2206898013155103151
(p238789801313090
=2507898013166
0,76),260389801315471123171197213
ani2846898013150108129
RFS8501048013156106154
(p1035104801312989
=11551048013165
0,85)1251104801315371126178204
při1486104801316192115
srovnání1631104801314172129177236285343364
odpovídajících20261048013158119178237286309368417439460508530578636
skupin2692104801314186144204226284
pacientů.8501198013160109157179230288319376392
Podání12621198013155109169217274295
intravezikální1577119801312379111142191238289333355400450471528549
léčby2146119801312375124182229
vakcínou2394119801315099144190211268326383
BCG27971198013155116179
u8501348013157
pacientů9261348013159108155175226282313368
s13131348013140
nálezem13721348013157104126177220269356
T0,17461348013151100117
Ta1881134801315090
a19901348013149
CIS2057134801316282129
v22051348013149
reTUR2272134801313282123191243
významně2534134801314999144201248335390442
souviselo850149801314198155203226264316338395
s12651498013140
delším13251498013159111133171192280
OS16241498013173122
(p1765149801312989
=18731498013165
0,03)1958149801315369122171195
a21731498013149
PFS22421498013155102149
(p2411149801312888
=25181498013165
0,01).2603149801315370122169189203
Ná‑28261498013169117150
lez850164801312374117
karcinomu986164801314695125171191247304391447
během14521648013159112168219306
první1777164801316091142199220
a20161648013149
druhé2084164801315889145201253
reTUR2356164801313282123191244
zvyšoval2619164801314395145184241287336357
riziko85017980131325599121167223
budoucí10981798013160118178236294342364
recidivy.1486179801313384134156215236286338351
Závěr:10001944013562119173228267293
Provedení1321194801315586142190242303355413435
další17851948013160109131170191
doby20061948013160118178225
transuretrální2260194801313466116174213270301352386417467489547568
re‑2858194801313284119
sekce850209801314092136182231
v11002098013149
případě1168209801316090112170218276327
opakovaného15142098013158117165209264311360416468524581
nálezu21142098013158105126178221277
T124102098013151100
karcinomu2529209801314595125170191247304391447
v8502248013150
reTUR920224801313384127197251
je1192224801312376
možné12882248013190149191250303
považovat16112248013161120168218262319367417449
za2080224801314595
bezpečné.21962248013161115159220274323381434451
Dle2667224801317195147
na‑28352248013159108141
šich850239801314061107163
dat,10322398013158106136154
případné1205239801315990111169217275331382
komplikace16062398013145101188245267288331381428477
plynoucí2102239801315981127185241297344365
z24862398013143
provedení2548239801315990145191242300351407428
další8502548013160109131169191
doby10632548013159117178225
TUR13102548013151120175
či1506254801314971
oddálení15992548013158118178227249302360381
případné2002254801316192115174224284342395
intravezikální2418254801312381113144194242294338361406457479537558
terapie,850269801313383113161219241292308
nezhoršují11762698013158110153210266297337392413433
OS.16282698013173121139
Nález17852698013169117138189232
nádoru20362698013158105163220250307
při2362269801315990111
první2492269801316091142199220
a27312698013149
dru‑2799269801315888145177
hé8502848013158109
reTUR978284801313282123191243
je1240284801312374
u13332848013157
pacientů14092848013159108155175226282313369
s17962848013141
T11855284801315099
karcinomem1973284801314695125170191246303390442528
močového25202848013188145193247293343400456
měchýře8502998013190143192250296329380
rizikem125429980131325599121167218307
pro1585299801316193150
budoucí17592998013160119178236294343364
recidivu.2148299801313284133155214236285343362
KLÍČOVÁ8523284014770132164236320392464
SLOVA13433284014762123207279351
Karcinom8503448013155106137184206263321411
močového12853448013190149198254302354412470
měchýře,17793448013190143192250296329380397
reTUR,2200344801313284127197251271
pT1,24953448013161105155167
BCG.26863448013155118181201
SUMMARY8523734014762143243345423493561
Košík10003898013155113153175223
V,1256389801315668
Pešl13563898013156107148170
M,15593898013186106
Šlemendová1697389801315274127217271329389448497547
M,22773898013186105
Kantorová24153898013155107165197254286344392443
A,2890389801316586
Fiala850404801315070117138185
V,1053404801315565
Čapoun11374048013161109167224280336
O,1491404801317287
Soukup15964048013150107163206262320
V.1934404801315567
Prognostic2019404801315483138196252308347380401447
significance2485404801314060117173193218244291339395442491
of850419801315886
multiple9574198013189146168201223282305357
transurethral1335419801313365115172211267298350382440471521543
resection1898419801313283123176225261283340399
in2317419801312380
patients24174198013161110142164216274305347
with27844198013179101135192
T18504348013151102
bladder976434801316184132192251304335
cancer.1336434801314998156205256287301
Aim:1000449401357098190215
The12454498013151111164
aim1439449801315071160
of1629449801315886
this1745449801313492114153
retrospective1927449801313384117149205245305359408444466516567
study2524449801314175133193241
is2794449801312362
to2886449801313490
investigate850464801312381128180220255277336385417468
whether13504648013180138192225283336367
multiple17504648013190147169202225284307360
transurethral2142464801313466116174213270301353386444475525548
resec‑2722464801313284124177227254
tion850479801313354110167
(reTUR)1036479801312856106147215268294
in1349479801312278
patients14464798013160108139160211267297338
with18024798013178100132188
T12009479801315099
urothelial2127479801315787142173230281302323370391
carcinoma2536479801314997127172193249305392440
of850494801315988
the971494801313594148
bladder1152494801316286135196257310343
leads1528494801312377126187227
to1788494801313592
worse19134948013180139171213267
prognosis2213494801316295152214273332373395435
and26814948013151110170
to2884494801313592
evaluate8505098013153102152174231280312363
the1239509801313492145
significance1410509801314163122180201227254302352410458509
of1945509801315987
individual2059509801312380140161211233293350398421
prognostic2506509801316092149209267325365400422470
factors850524801312979128164220252293
in1167524801312381
the1272524801313492145
first144152480131275384125160
and16255248013150108167
second1816524801314194144200258318
reTUR.2158524801313284127196251272
Methods:10005393013592150189253315380427452
A14855398013165
total1583539801313491124174197
of1812539801315988
36319335398013154107159
patients21255398013161112144167220279311353
diagnosed2511539801316183132192251310350404465
with8505548013180103136194
T110775548013151102
urothelial1211554801315991147180239292315336385407
carcinoma1651554801314999130178199257316406455
between21395548013161115148230283337395
200125675548013153105161209
and28085548013150108168
20228505698013155108160214
were10985698013182136168222
included1354569801312383133156215277331394
in1782569801312383
this1899569801313494117158
retrospective2091569801313386121154212254315371422460483534588
study,2713569801314278137199249263
of850584801316090
whom9745848013182143204297
26013055848013155108164
patients15035848013162115148172227287320364
underwent19015848013160120182237270356410470504
at2439584801315185
least2558584801312479129171207
one27995848013160121176
reTUR850599801313386130201256
and11395998013151110171
10313435998013154102153
patients15295998013162113146169222282314357
did1919599801316183143
not20955998013160120153
undergo22815998013159118179233265324383
reTUR.2698599801313285129200256278
By8506148013156104
default,9766148013159112140191248270303322
if1320614801312351
a13936148013150
pT114646148013161104155
tumor1641614801313491180239271
was19336148013179129169
found2123614801312986144202262
in2406614801312381
TUR,25086148013151121175195
reTUR2725614801313284127197251
was8506298013179129169
indicated1046629801312380140161210259292343403
until14766298013158116148170191
histology1694629801315981120154210233291352400
was21216298013179129169
pT0,23176298013160104156173
pTa,25176298013160104145164
CIS,2708629801316284133151
or2885629801315991
a8506448013150
muscle-infiltrating9266448013190147186235257310344368425451477499532564614646668726785
tumor1737644801313492180239271
was20336448013180130169
diagnosed2228644801316082130189247305345398459
(stage2712644801312968102152211264
pT28506598013161104159
or1038659801315991
more).11596598013190148180232257272
We14616598013190140
used1631659801315898151211
the1872659801313492145
Kaplan-Meier20476598013154106165188237295328414468489542573
survival2650659801314198129182205254304326
distribution850674801316082121155187210269327361383440499
function1376674801312988145194230252310369
estimation1772674801315393128150238287320342399458
method22576748013190143176234293353
and26376748013150108167
the2831674801313492145
log-rank850689801312482144177211262320366
test1249689801313586127163
to1444689801313592
compare15686898013150107198258309341393
each19946898013154103152211
group2238689801316092150208269
according25406898013150100147204236295317376436
to850704801313490
the967704801313493146
number11407048013159116205265319350
of1518704801315886
reTURs.1632704801313284127197251293312
The19727048013151111164
effect2163704801315483112164214250
of2441704801315886
individual2555704801312380140162211234293350399421
prognostic850719801316194152213272331372407430479
factors1362719801312981130167224257298
in1693719801312482
multiple18087198013191149172206229289313367
reTUR2208719801313285129200255
was24967198013180131171
tested2700719801313587128163215276
using850734801315898119177236
Cox11107348013163119164
regression1299734801313284144175227267307328386444
model.17677348013190149209262285303
Results:10007493013563119165227255293340365
When13977498013190150203261
comparing16907498013149105195254304335358416475
the2197749801313492146
groups2375749801315991147205265305
of2712749801315987
pa‑28317498013161111145
tients850764801313558112171204247
without11317648013181104138198258318352
reTUR1517764801313386130202258
with18087648013181104139199
the2040764801313594149
groups2222764801316194152211273314
with25697648013181105139199
one28017648013160120175
reTUR,320389801313284127197251271
two3498898013134116173
reTUR,369589801313384128197252272
and3991898013150108167
three418289801313492123175229
or443589801315890
more4549898013190149181232
reTUR,480589801313384127197251272
there510189801313492145176228
was32031048013178127165
no33871048013158115
significant3521104801314161119175196221247295343399430
difference3970104801315980108138189219269326373423
in4412104801312279
overall45101048013157104155185234255276
survival4805104801314196126178200248296317
(OS),5141104801312998146173188
disease-specific3203119801315979117168215253305338377434487535555580606653
survival3875119801314095125176198245294315
(DSS),4208119801312997145192219233
and44601198013149105163
progression-free4642119801315990145203233283322360381437493526553585635687
survival3203134801314197129182205254304326
(PFS)3556134801312983131179207
in3790134801312381
the3898134801313492145
entire40701348013153111143165196248
cohort43451348013149105163222254291
of4663134801315887
36347771348013153106157
patients.49611348013160110143165217275307349368
Recurrence-free32031498013157113166226260294349410461515552583618672729
survival39741498013143102136192216268321345
(RFS)4361149801313188141192222
significantly4625149801314266128189212240268319372432467491542
in‑5209149801312484120
creased3203164801314878129175214265324
with3546164801317899131188
the3753164801313389141
number39131648013158113200258311341
of4273164801315784
procedures4376164801316091146194243302357387437476
performed48711648013160112143173229260348399458
(p3203179801312989
=33211798013165
0.02).3415179801315471125174200215
Administration36591798013164122211233291312351386418467500522579638
of4325179801315987
intravesical4441179801312380112144194241293333355403453475
BCG49441798013156118181
vac‑5154179801315099148175
cine3203194801314971128181
was34101948013180129169
the3605194801313492145
only37761948013158117139187
independent3989194801312380139192252306364423476534566
prognostic4581194801316092149209267325365400422470
factor5077194801312979128164220252
in3203209801312380
multivariate33032098013190147169202224273322353376424456506
analysis38302098013149107155177225265287325
in4175209801312381
relation4276209801313283106154186208265324
to4620209801313489
OS47302098013173122
and48722098013150108167
PFS.50592098013155103151169
In5248209801312481
14732032248013154100148
patients33792248013161111143165218276307349
with37562248013179102135193
T139772248013151102
urothelial4107224801315890146179237290312334382404
carcinoma4539224801314999130177199256315404453
treated5020224801313466117165197248309
with32032398013180103137195
intravesical3431239801312381114146196245297338359408458481
BCG39452398013156118183
vaccine,41602398013150101150197219277331348
there4541239801313493146178230
was48042398013180130170
also5007239801315073112171
no52112398013159118
significant3203254801314061118174195220246293342398429
difference3651254801315879107137187218268324371421
in4091254801312278
OS41882548013173121
(p4328254801312887
=44342548013164
0.72),4517254801315370120171196211
DSS47472548013170118165
(p4931254801312987
=50372548013165
0.75),5121254801315269119167193208
PFS32032698013155104151
(p3382269801312990
=35002698013165
0.76),3593269801315472123171198213
or3834269801315890
RFS39522698013156106154
(p4134269801312990
=42512698013166
0.85)4345269801315472126178204
when45772698013180138191249
comparing48542698013149105195254304335358416475
matched32032848013193144178226286342404
groups3642284801316194153214276318
of3994284801316090
patients.41182848013163115149172227287321365385
Administration45382848013166127219242302325366402436488522545605666
of5239284801316090
intravesical3203299801312380111143192239290330351399448470
BCG36932998013155117180
vaccine3893299801314998146192214271323
in4236299801312380
patients43362998013160110141163215273304345
with47012998013179101134192
T0,49132998013150102118
Ta5051299801315192
and51632998013150107166
CIS3203314801316384133
findings3366314801312753111170192250309348
in3745314801312380
reTUR3856314801313284127196251
was41373148013179129169
significantly4336314801314163122179201227254302352410441464512
associated4878314801315090130188237259307339390451
with32033298013178100132189
longer3411329801312379136194246276
OS37063298013173121
(p3846329801312987
=39523298013165
0.03)4036329801315370122170194
and42493298013149105163
PFS44313298013155102148
(p4598329801312988
=47053298013164
0.01).4788329801315370122169188202
Finding5009329801315071127185206262320
cancer3203344801314897154201251282
during35043448013159115146168224282
the3806344801313390142
first396834480131265283123156
and41443448013149106164
second4327344801314193141196254312
reTUR4658344801313283125193247
increased4924344801312379127157208255294346405
the3203359801313492145
risk337235980131335594139
of3535359801315987
future3646359801312988122179211262
recurrence.3932359801313384134191222255306364413463481
Conclusion:33533744013565125188237265327373400462525549
Performing39313748013155106137169226258348370428487
an44463748013150108
additional45823748013149109168190224246303362411433
period50433748013161115146168226287
of3203389801315987
transurethral3316389801313466116173213269300352385443474524546
resection3888389801313384125178227263285343402
in4316389801312380
case4422389801314999139192
of4640389801315887
recurrence4753389801313284133190222254306363412463
of5242389801315887
T132034048013152105
carcinoma33424048013150101134183205265325418468
at3844404801315185
reTUR3963404801313386131203259
can42564048013150102162
be44514048013163119
considered46034048013151109169210232294348381435497
safe.5134404801314294123177195
According32034198013166115164222255316339399460
to3697419801313593
our38244198013160121153
data,40114198013162113146198218
potential42634198013162123157210271304327377401
complications46984198013150108201263287310360412446469529590631
resulting3203434801313282120175196228249304362
from3583434801312960115202
performing38044348013159112142172228258346366422480
an43024348013149105
additional44264348013149106164185217237293350397418
TUR48634348013150117170
period50524348013159111141163219277
or3203449801315890
delaying33124498013160112134182228251307366
any36984498013150107152
intravesical3870449801312380111142192239290329350398447469
therapy4359449801313391143174224282329
do47084498013159117
not48444498013159117148
worsen50124498013179136167208260317
OS.32034648013173122140
Tumor33634648013150100187245276
finding3659464801312652109167189245304
at3982464801315081
first408346480131265383123157
and42604648013149106165
second4444464801314193142197254313
reTUR4776464801313383126194248
is5043464801312361
a51244648013149
risk519346480131325492137
for3203479801312986118
future3353479801312988121179210262
recurrence3646479801313384134191222255306364413464
in4141479801312381
patients42544798013160110143165217275307349
with46344798013180102136194
T148604798013151101
bladder4993479801316184132192251304336
cancer.3203494801314999157205256287302
KEY32045234014770134206
WORDS343752340147105189260345408
Bladder3203539801315678127186246299330
cancer,3557539801314999157205256288301
reTUR,3882539801313284127197251271
pT1,41775398013161105155167
BCG.43685398013156118181202
………320356840147120240360
ÚVOD32056108018197183286388
Karcinom32036448013155107139187210269328419
močového36516448013190150200257306359418478
měchýře41586448013190144195253301334387
(KMM)4574644801312983172258285
je4888644801312478
v49956448013150
České50746448013163115156202255
republice3203659801313285146205266290312362414
jedním3647659801312377138197220310
z39866598013145
nejčastěji40606598013159114137186236277313365388411
diagnostikovaných4500659801316083132193252311352388411457515565615674721770829
zhoubných32036748013145105166226287348396445505
nádorů37436748013160110172232266326
močového41046748013191151202260310364424485
traktu.4624674801313468119167205265285
V49456748013156
pořadí50366748013162123156208270293
všech3203689801315091145196254
nádorových34866898013159109170229262320369422471530
onemocnění40446898013159119173263322373432486545567
jde4640689801312484138
celosvětově48076898013149101125184225276329363420469522
o32037048013160
sedmé3299704801314298161254310
nejčastěji36457048013160116140191243286323376400424
diagnostikované4105704801316185136199260321364401425473532584636697753
nádorové48947048013160112174235270329380435
onemocnění32037198013159118172262322372432486544567
u38027198013159
mužů38937198013190148193252
a41777198013150
sedmnácté4260719801314195156246305355405442494
u47867198013159
žen4877719801314497156
(1).506571980131297899115
In‑5212719801312482117
cidence3203734801314972132186245295347
onemocnění35857348013158118172262322373432486545567
stoupá4187734801314176134193254305
s45267348013141
věkem46017348013150103149202293
pacienta,49287348013161112162184238297330381401
dvě32037498013160110163
třetiny3397749801313467119153176235282
onemocnění37107498013158118172262322372431485544567
se4308749801314195
vyskytují44347498013149103144190243281340364386
u48517498013158
pacientů49407498013161112162185238297330389
starších3203764801314278130163205228278338
6535767648013155108
let.3719764801312479114134
Do38887648013173134
roku4057764801313391139200
200542927648013154108165219
bylo45467648013161110135196
možné47777648013191151196257312
v51247648013150
ČR52107648013163119