342
2055579220014562121180
Ces36967930014570127174
Urol38957930014578115180208
2024;41287930014562121178235258
28(3):44117930014562121154212241263
205–21347007930014561120180241296350403
PŘEHLEDOVÉ3674200016974156235334409485586692777855
ČLÁNKY4576200016981154252352436525
Potenciální7651070028912825232844357467973184489710261079
markery189510700289200312387497612688806
karcinomu2752107002891132283034074595887189161044
prostaty384710700289136213341432511625700817
v76513700289115
moči93113700289200330436488
Potential7651790015769137179242313354383444473
markers126617900157108169211271333375426
of17201790015771108
prostate18551790015774116186236279341382445
cancer23281790015758120191249311353
in27081790015731101
urine28371790015771113142213277
Tereza6242530014763116159220273335
Zdobinská,9842530014768137204273303371420480542570
Štěpán15792530014762101161231292360
Veselý19642530014772129178240270330
Urologická6242830014375108169194257322345398446501
klinika115228300143507699162185234289
2.1467283001435877
LF15712830014353107
UK17052830014375133
a18642830014354
FN19452830014355128
Motol,21002830014393156191252276295
Praha2421283001436093147210262
Došlo:6243140013171130170192250267
22.9153140013154107125
10.10643140013153100118
202412063140013154106155203
Přijato:624329001315586108130178210266284
15.932329001315398115
11.1071329001315494107
202412023290013154105155203
Střet624359001355794133189228
zájmů:8753590013549106135228290315
Žádný.12123590013159109169227273286
Kontaktní6243890013564124187224281336378440468
adresa:11143890013556120159215261318342
MUDr.6244040013186153223255269
Tereza917404001315197129180225276
Zdobinská12174040013159116175235257315354399450
Urologická6244190013169100156179237298319368413464
klinika111241900131467192150171217267
2.1403419001315472
LF1499419001314999
UK16224190013169123
a17694190013150
FN18434190013151118
Motol19854190013186144177233256
V6244340013156
Úvalu7044340013169118168190247
84,9754340013154109126
1501125434001315499150
0612994340013154109
Praha1432434001315585135193242
e-mail:624449001315388178227249271288
tereza.zdobinska@fnmotol.cz9364490013134851171682132632823293874455065285866256707218008298899781036106811241148116612141261
Podpora:6244790013561122186250313352407432
Zpracování10784790013159119151200249305353403461483
tohoto1585479001313490148206239295
článku1904479001314971119177223281
nebylo22094790013159112171219242300
podpořeno6244940013161120180240299331382440498
žádnou1146494001314595155212271329
společností.14994940013141100159182235284342400440475497515
SOUHRN6255230014762148230313383467
Zdobinská7745390013159117175235258315354399450
T,1248539001315263
Veselý13355390013156106146199222270
Š.1629539001315167
Potenciální17215390013155111143194252300322370393450472
markery22175390013190139170216268299351
kar‑2592539001314798129158
cinomu624554001314971128187276333
prostaty981554001316193150190224274306357
v13625540013150
moči.14365540013190149198219238
Karcinom7745690013155108141190213273333425
prostaty1234569001316295154196232284317371
je1640569001312378
jedním1753569001312478141201224315
z21035690013145
nejčastějších21835690013159115138188240281317370394434457507567
onkologických6245840013159118165223247306367390439486539587646
onemocnění12965840013159118172262322373432486544567
mužů18895840013190149194252
ve21685840013149102
světě.2296584001314193146179231249
Dia‑2571584001317295145179
gnostika6245990013160119178219255278324376
a10345990013150
stratifikace1119599001314176109160193216244270316368418470
pacientů16235990013161112162184238297330389
jsou2046599001312363123182
klíčové226259900131477295143200250303
pro2599599001316094151
zajištění624614001314599123147189225279340364
včasné10236140013151101154196256312
a13716140013151
adekvátní14586140013151114170218274326361422446
terapie.1940614001313589123175238263318337
Současné23136140013153114175226278321381437
standardy624629001314177127186247297329388437
se1084629001314196
opírají12036290013158120143175226250272
převážně1498629001316194146196247293352406
o19276290013159
PSA,20096290013155106169191
jehož2223629001312377136196239
nádo‑24856290013159109170229265
rová624644001313392142194
specificita8546440013141103159211234262289340363399450
je1340644001312378
limitována.1454644001312347138162197255306358418469490
Tento19796440013152100160194252
přehled2266644001316296149210234289351
se2653644001314197
zaměřuje624659001314494183236266324346399
na10446590013159107
neinvazivní11736590013158111133190237287332355404463485
potenciální16796590013160119152203260309331379402459481
onkomarkery21816590013158116162218307356388434485517569
získané624674001314468108154206265320
z9786740013144
moči10566740013191150201223
včetně1314674001314998149184243297
oxidačního16456740013159106129190240289348371432492
stresu,2171674001314177109162204261280
meta‑24866740013190144178229264
bolomiky6246890013161121145204295318364417
a10736890013150
analýzy11556890013150109159182231279332
nukleových15196890013159117163189243303352405454513
kyselin.2064689001314699141195218241300320
V24166890013156
rámci2504689001313283173223246
některých6247040013159113160198250283336385444
studií1102704001314177136197220243
se1379704001314195
ukazuje,15097040013158105157203262286340358
že1901704001314497
zvýšené2032704001314599152194248307361
hladiny2428704001315982132193216275322
markerů6247190013190141173221273306365
jako1024719001312473120178
F2-isoprostanáza,12377190013151103134158199258320353411452488539598648694746766
sarcosin2037719001314193125173231272295353
a24257190013150
PCA325097190013156119186241
mohou6247340013189147206264322
indikovat968734001312380140162207264312362395
přítomnost1384734001316092115149205294352410450485
a18917340013149
agresivitu19627340013149108140192232254303326360418
karcino‑2401734001314697129176198255314349
mu6247490013190148
prostaty.801749001316194151193228279312365379
Nové12097490013170130179232
kombinované14707490013146104195255279338397446497556610
testy2109749001313486128163216
Prostarix,2353749001315587145186221272304328376397
Mi-Prostate6247640013186109143200232290331366417450502
Score,11527640013151101158191243261
SelectMDX14397640013151105129182233270357428485
nebo19497640013159114174235
ExoDX22097640013151102159231289
nabí‑25237640013159109169193227
zejí2976314001314598122145
potenciál31563140013161122156209269319343393417
pro3608314001316195153
zlepšení3796314001314569124185227282342365
stratifikace4196314001314177111163196220248275321374424477
pacientů47083140013161113164187241301335394
a29763290013150
snížení30603290013141100122167220279302
počtu33963290013161121171208267
negativních36973290013159114175225258281332392415464522
biopsií.4254329001316084143204245268290310
Klinické4598329001315580103162184234280333
vy‑49653290013150103137
užití29763440013159104127162185
těchto3196344001313486136195228285
nových35163440013159118168221270329
markerů38793440013190140173220273306365
je4278344001312478
zatím4390344001314597130153243
omezené.46683440013158149204249302361416434
Vzhledem29763590013156101161184238299353443
k34433590013146
heterogenitě35133590013159113147199232290351405464487521573
tohoto4110359001313491150210243300
onemocnění44343590013159118172262322372432485544567
je5025359001312377
nezbytné29763740013159113159220269307366421
pokračovat34193740013161121169203254304360410461494
ve39363740013149102
výzkumu,40613740013150103151198257347405424
který4508374001314784137169222
usnadní4753374001315898157207267326349
personalizovaný29763890013161116148190250309359382405450508557608667714
přístup3716389001316194117157193252312
v40553890013149
léčbě.4131389001312377127188243261
KLÍČOVÁ29784180014770132164236320392464
SLOVA34694180014762123207279351
Karcinom29764340013156111145194218279341435
prostaty,3458434001316397157200237290325379394
onkomarkery,38994340013161122171231325377411460515549604619
biomarkery,4565434001316388149243295329378433467522537
prostatický2976449001316294152193228279312335384430483
specifický34924490013142102157208230257284333380432
antigen39584490013150109142164225279338
(PSA),4329449001312985135199228244
neinvazivní46064490013160114136195243294340363413474496
diagnostika,2976464001316184133194253313354390413459511530
oxidační35404640013159106129190240290349371
stres,3945464001314277110163204223
metabolomika,42024640013192146180231292353377436528551597649668
ami‑49044640013151141164198
nokyseliny,29764790013160120167220261316339361420467481
sarcosin,3490479001314294126174231272294353372
exosomy,38954790013154103161202261353400414
microRNA,43424790013192114164196254311382447468
PCA3,48434790013156119186242259
F2-isoprostanáza,2976494001315099128150187244302333387426459507563610653702719
diagnostika,3714494001315879126183239295334367388432481498
stratifikace,4231494001314073103152182203228254297347393443458
agresivita47084940013149106136186225245292314346394
nádoru,29765090013159108167225257316334
biopsie3334509001316083141201241262315
prostaty.3673509001316193149189224273305357370
SUMMARY29785380014762143243345423493561
Zdobinská31265540013159115172231253310348392442
T,3588554001315061
Veselý36695540013155103143195217264
Š.3952554001315167
Potential40385540013155109141191248279300348369
markers44275540013189137167213263294334
of4780554001315886
pros‑4885554001316092147186217
tate2976569001313484116167
cancer3167569001314999156205256287
in3478569001312381
urine.3583569001315890112170223240
Prostate3126584001315687144185220270303354
cancer35135840013150100159208260292
is3837584001312463
one39335840013159118172
of4138584001315988
the4259584001313493147
most44385840013191150191226
common46975840013149106197287346405
oncological29765990013157114161215237293351372418466487
diseases3481599001315979117168214253304342
among38415990013149136192249306
men41655990013189140196
worldwide.43795990013178133164185243319340397449465
Accu‑48625990013163108153208240
rate2976614001313282115166
diagnosis3164614001316082130189247305345367406
and35926140013150108167
patient37826140013161111143165217275307
stratification4112614001314175107157189211237264312362394416474532
are4667614001315081133
crucial4822614001314981139188209258280
for2976629001312986118
ensuring31216290013154112151208239261319378
timely3527629001313456145198220268
and38236290013150108167
appropriate40186290013149109169201258318350373421453504
therapy.4550629001313492145176226286333346
Cur‑49246290013162118149178
rent2976644001313284141173
standards3169644001314176125183242291322380419
primarily3608644001316193115204252283306328376
rely4004644001313284106154
on41786440013159117
PSA,43156440013155105167187
whose45236440013179137195235288
tumor4831644001313492181239271
specificity29766590013141100154204225251278327348382433
is3438659001312362
limited.3529659001312344133155188239300318
This38766590013151111133172
review4077659001313284133155208286
focuses4392659001312986136193233286326
on47476590013158117
noninvasive489365900131591171752976674001312378124172210230278328
potential33226740013159117148197253283304351372
oncological37126740013157114161215237293351372418466487
markers42186740013188135165209259289329
derived45656740013159110140161209259317
from4900674001312860115202
urine,2976689001315788109165217233
including3228689001312279126147202260281337395
oxidative36426890013158102123181228260281329379
stress,4040689001314074104154193232250
metabolomics43096890013188140172220278336358415502523570611
and49396890013149105163
nucleic29767040013159117166188242264313
acid33217040013151100122181
analysis.35357040013150109158180229270291331351
Some39187040013152111201255
studies4205704001314176135195217270311
indicate4548704001312381141164212263295347
that4927704001313493142175
elevated2976719001315376129178227259310371
levels3371719001312376125176199238
of3633719001315887
markers37447190013190139170216268299340
such4108719001314198146204
as4336719001315089
F2-isoprostane,44497190013151102132155194252313345401441476525583636653
sarcosine2976734001314191123170226266287345398
or3406734001315890
PCA335287340013156118183237
may37977340013191140186
signify4015734001314162122179201230282
the4329734001313492146
presence4507734001316092144184237295344395
and49347340013150108167
aggressiveness29767490013150109168199250290329350399451508561601640
of3637749001315886
prostate3743749001316192148188222272303354
cancer.4117749001314998156204255286300
New44377490013170122200
combined46587490013148104193252275332385444
tests2976764001313485125160201
Prostarix,3207764001315585142182216266297320367387
Mi-Prostate36237640013185108141197227284324358408440491
Score,41437640013152100156188240257
SelectMDX44297640013151104127179229265350420477
and49357640013150108167