600
2155585220014562116169
Ces36927930014570127174
Urol38917930014578115180208
2024;41247930014562121178235258
28(3):44077930014562121154212241263
214–22046967930014561116169232287347406
ORIGINÁLNÍ3862200016996181224324367468561635735777
PRÁCE4686200016974156253339415
aplikací624890013150109132154199250299320
v965890013149
letech103589001312376109160209267
20191323890013153105152197
a1541890013150
20201611890013154105155206
bylo1838890013161108131189
dáno2047890013160109167225
výpadkem2292890013150102163213272318369458
dostupnosti6241040013160118158192250310368426466501523
MMC11711040013186170232
a14271040013150
epidemií15011040013154113136195248337359380
COVID-19.19061040013162131186209279315361406421
Závěr:7741190013562119173228267293
Údajů10901190013169128177199256
o13701190013159
reálné1453119001313384132154212265
praxi1742119001316193143191213
jednorázové1980119001312376136194252284334379435484535
insti‑2540119001312380120154176210
lace624134001312372120171
chemoterapeutika8161340013149106159248307339390421471531585642675697742793
po16301340013160119
TURBT17701340013151121175230281
je2071134001312476
málo21681340013190139161219
a24071340013150
svědčí2477134001314192143203252273
spíše624149001314199121162214
pro857149001316092147
její102414900131237596117
nízké1161149001315879122167218
využití.13991490013149100158201223255277294
Dle1713149001317093145
našich18781490013158106145165213270
dat21671490013159107139
je2325149001312375
podaná24201490013160118177225282330
přibližně624164001316091113172195216259317369
u10121640013158
třetiny1090164001313465115148170226272
potenciálně13821640013160118150200258305327374396453505
vhodných19071640013149107165224281327373430
pacientů.23571640013160110158179231288319376393
Interpretaci624179001312381113164195256288339372422471492
výsledků11391790013150102142164217277323381
ztěžuje1542179001314582132177235257309
nedostatek18741790013159112172230270305355387438483
informa‑2380179001312381108166198288336370
cí624194001314971
o7271940013158
důvodech8171940013160117166224284337386444
nepodání12931940013159112172231292340398420
MMC17451940013186170232
při2009194001316193115
retrospektivní2156194001313384117149206246305359405442464513572594
analýze6242090013150108156179227273325
dokumentace.9732090013160118164222311364422454503552603620
KLÍČOVÁ6252380014770132164236320392464
SLOVA11162380014762123207279351
Karcinom6242540013154103134179200256312400
močového10432540013188145193247294344401458
měchýře,15192540013189141188245289321370386
pooperační19242540013160117175233286316365412468489
intrave‑2431254001312379110140189235285319
zikální624269001314467112162184241263
CHT,9072690013163130181193
single1120269001314162119179201253
shot1393269001314198156189
mitomycin16022690013190111144200289335383404461
C,2084269001316280
transuretrální2185269001313465115172211268299350383414464486543565
resekce624284001313284124177223270321
močového9692840013190148198253302354412470
měchýře.14632840013190143192250296329380397
SUMMARY6253130014762143243345423493561
Wasserbauer7743290013193143185227283317380433493548582
R,1397329001315779
Papirek15173290013157108170195228282331
J,1888329001314058
Hudecová19873290013171132194250302361412465
E,2492329001315374
Fe‑26073290013152106143
dorko6243440013160119151198256
M.9123440013186107
Evaluation10523440013151100150173230280312335393452
of1537344001315988
the1657344001313493147
use1836344001315999153
of2021344001315988
postoperative21423440013161121161196253314368400451483506556608
single-shot624359001314162120179201254289329387445477
instillation1124359001312381120155177199220269301323381439
chemotherapy15863590013149107160249308340398451482532592639
after2248359001315078116167198
TURBT24693590013151121175230281
and6243740013150108167
reasons815374001313384132172230289328
for1167374001312986118
not13093740013159117150
administering14833740013150109198220278299338373424455478535595
it.210237400131235675
Aim774389001357098190
of986389001356297
Study:1105389001355895156220275302
Mitomycin14303890013186108141197287333381402460
C19133890013163
(MMC)19993890013129112196258289
instillation2311389001312381120154176198220269301323381439
after624404001315180119172204
transurethral862404001313568119179220278310364398458490542565
resection1461404001313386128183234271294354414
of1909404001316089
bladder2032404001316286136198259314346
tumour2412404001313594186246306338
(TURBT)624419001312984153208263314347
reduces998419001313384144201250301341
the1367419001313492145
risk153941900131335695140
of1706419001315987
bladder1821419001316083132192251304335
cancer2184419001314999156205256287
recur‑2499419001313284133191222251
rence.624434001313282139186236252
The8954340013150109161
aim1075434001314970157
of1251434001315785
this1355434001313390111149
study1523434001314074130188235
was17774340013179127166
to1962434001313388
evaluate20694340013152100148170225273304354
the2442434001313390142
use2603434001315795147
of624449001315987
single737449001314163120180202254
postoperative10184490013161120160194250311365396446478500549601
chemotherapy16464490013149106159249307339397450482532591638
instillation2311449001312380120154176198220269301323381439
after624464001315078115166198
TURBT8494640013151121175231281
at1158464001315082
our12684640013158116147
institution1443464001312380120154176210267301323381439
and19104640013150107167
the2104464001313492145
reasons2277464001313284132172230288328
for2632464001312986118
not6244790013159117150
administering7984790013150109198220277299338373424455478535594
it.141747900131235675
Patients7744940013561115152179234296333379
and11724940013555117179
Methods:13704940013590147185246307371416440
A18284940013164
retrospective1911494001313383116147202242300353402438459508559
evalu‑24894940013153101150172228260
ation624509001315083105164223
of879509001315988
a9995090013151
cohort10825090013149106165224256294
of1408509001315988
patients15295090013161111144166219278310352
undergoing19135090013159118178231263321380403461521
TURBT24665090013152122177233284
from624524001312962118208
2016–2022.8565240013153105153199257304356406458476
The13565240013151111164
total1544524001313490122172194
number17625240013159116204264318350
of2135524001315987
TURBTs22465240013151121175230281313
and25835240013150108167
the624539001313492145
total796539001313490122172194
number10175390013159116205265319350
of1394539001315987
single-shot1508539001314162120179201254289329387445477
MMC20125390013186170232
instillations2271539001312381120155177199220269301323381440479
(SS-MMC)624554001312977126159246330392422
were10695540013179131163214
evaluated.13065540013153102152174231279312363423442
In1770554001312381
particular,18735540013161111142179201249307329378409422
the2317554001313492145
group2485554001316091147205265
of624569001315987
patients7325690013161110143165217275307349
with11025690013179102135193
no13165690013159117
obvious14545690013158119167190248306345
reason1820569001313284132172230288
for2129569001312986118
not22685690013159117150
admin‑24395690013149109198220277311
istering624584001312465101154187211271333
MMC9925840013188176241
was12675840013182134176
evaluated.14775840013155106158182241292326380442462
Furthermore,19745840013152110143182242298331424485519573591
the2599584001313596151
reasons624599001313282128166223279317
for960599001312884114
not10935990013158114145
administering12575990013149107193214270290328361410440462517575
MMC18515990013184166226
were20965990013178128158208
evaluated.2323599001315299147168223271301351409427
Results:7746140013564124172237267308356383
During11956140013173135168193253315
the1551614001313596152
follow-up1743614001313090115139200281317379442
period,22256140013163119153178238302321
73525876140013155110162
TURBTs6246290013150119172226276307
were9506290013178129160210
performed11806290013160112143174230261350402461
in1660629001312379
53817586290013153102153
men19306290013189141198
and21476290013149106164
1972330629001315397146
wom‑24956290013178135223255
en6246440013153111
(mean7636440013129115168216274
age10656440013150109162
7112556440013153102
years,13856440013148100148179220239
median16516440013191144204226274332
7520106440013154103
years)21416440013148100148180221245
and24146440013150108167
21126096440013153101141
SS-MMCs624659001315199132218302363404
(28.7%)1048659001312980130149200279304
were13726590013179130161212
administered.16046590013150109197218275297335369420451502561580
After2204659001316491128179210
exclud‑24346590013153100146168224283316
ing624674001312380139
patients7846740013160110142164216274305347
with11516740013179102135192
macroscopically13646740013190138187218274314362418478500548598620642689
evident20736740013154102125184236294326
residual2419674001313283123145203260309331
tumor624689001313492181239271
and9216890013150108168
palliative11156890013161111133155176224257279328380
endoresection15216890013154112171229261313353406455492514571630
(n2177689001313084
=22886890013165
102)23806890013154101150176
and25836890013150108167
patients6247040013160109140162213270301342
with9857040013179100133190
endoresection11947040013153110168225256307346398447482503560617
for1831704001312884116
reasons1966704001313282129168225283321
other2307704001315789146198229
than2555704001313491138195
bladder624719001316387138200262317350
cancer10087190013151103163214267300
(n1342719001313087
=14647190013167
24),15657190013156106132149
60917487190013156112168
TURBTs19507190013152125182239292326
were23107190013182136169223
per‑25677190013163119152183
formed624734001312987120211265326
when9837340013180140194252
MMCs12687340013187173236278
could15797340013149106165188248
be18597340013162117
instillated.2008734001312482122157180202225274307359420439
In2480734001312382
this2595734001313493115155
group,624749001316091148206265282
the934749001313492145
representation1108749001313284143175227267320378410459492514571630
of1766749001315987
SS-MMC1882749001315199133219304366
was22767490013179129169
34.7%.24737490013154108125177257277
The6247640013150108159
most8017640013189145183216
common10357640013148102189276332389
identified1442764001312279130186217238262288339397
reason1857764001313282128166223279
for2154764001312884114
not22867640013158114145
admin‑24497640013149107193213269301
istering29768900131236296147179201259318
SS-MMC332089001315199133219304366
(n371189001312984
=3820890013166
398)3911890013153103157183
was4119890013180129169
hematuria4313890013159112201250282340371394442
(n478089001312984
=4889890013166
83,4980890013154105122
20.9%),29761040013154107125177260286302
bladder3311104001316185134195255309341
wall36851040013181131154177
perforation38941040013162117149182240273324357379438498
(n4425104001312985
=45431040013166
66,46421040013155110129
16.6%),48031040013155102122177257283299
and29761190013150108167
allergy316811900131507294147178236285
(n3478119001312984
=35871190013165
4,3678119001315370
1%).37731190013154127152167
In3965119001312481
24540721190013153101150
patients42481190013160110142164217275307348
(61.6%),4621119001313080125137191270295311
the4957119001313492145
reason2976134001313284132172230288
for3289134001312986118
not34321340013159117149
administering36061340013150109198220278299338373424455478535595
could42251340013149105163185245
not44941340013159118150
be46691340013160114
traced.4808134001313466116164215275294
The29761490013152113167
reduction3177149001313285147205255292315374433
in3644149001312382
the3759149001313494148
number39401490013160118209270325357
of4330149001316089
applications44521490013151112173197219269320353375434494534
in5020149001312382
201929761640013154105153198
and32051640013150108167
202034031640013154105155206
was36401640013180129169
due38401640013160117170
to4041164001313490
the4161164001313493146
lack4338164001312371120165
of4534164001315987
availability4652164001315098147169191240299322344365399450
of2976179001315987
MMC30871790013186170232
and33431790013150108167
the3535179001313492145
COVID-1937041790013162132186210280315361406
epidemic.41341790013154113136195248337359407426
Conclusion:31261940013566129194245274339386415479544570
Data37281940013173124157209
on39711940013160120
the4125194001313595150
actual43091940013151102140200250274
practice4617194001316295147198235259309362
of5013194001316089
single2976209001314162120179201254
instillation3258209001312380120154176198220268300323380439
of3724209001315987
chemotherapeutic38392090013149106159248307339397450482532591645703736758806
agents46732090013150109162220252294
af‑4994209001315078108
ter2976224001313487119
TURBT31282240013152122178234286
are3447224001315183135
scarce3615224001314292143175222274
and39222240013151110170
suggest41252240013142100160221275316351
that4509224001313594144177
its4719224001312357100
use4852224001315999153
is5038224001312464
rather2976239001313281112170222252
low.3248239001312380157171
According34382390013164111156211242299320377435
to3893239001313388
our40012390013158114145
data,41652390013160107139188205
it4390239001312255
is4464239001312361
administered45452390013149108195216273294332366416447497556
in2976254001312381
approximately30862540013150109169201258304326415464496547569617
one37322540013159117171
third3932254001313492113145202
of4164254001315887
potentially42802540013160120152203261293315363385407455
suitable4764254001314198119153202262285338
patients.29762690013161111143165217275307349368
Interpretation3368269001312381112163195255287339372422454476534592
of3983269001315987
the4094269001313492145
results4262269001313384124181203236278
is4563269001312362
hampered46492690013159107196256310341393453
by29762840013161108
the3112284001313492145
lack3286284001312372120166
of3480284001315987
information3596284001312380108165197287336368390448506
on41312840013158117
the4276284001313492145
reasons4450284001313284132172230288328
for4806284001312986118
not49532840013159117149
administering29762990013150108196218274296334368418449471528587
MMC35822990013185169230
in3832299001312379
retrospective3931299001313283116147203242300354403438460508559
analysis45102990013150107155176224264285323
of4853299001315886
the4958299001313491144
documentation.29763140013160118167225314367425457506538560618677696
KEY29783430014770134206
WORDS321134300147105189260345408
Bladder2976359001315578127186245298329
cancer,3326359001314998156205255287300
postoperative36463590013161120160194250310364395445477499548600
intravesical4266359001312381112144194241293333354403452474
chemo‑47613590013149106159248306341
therapy,2976374001313595150183235297346360
single3370374001314265125186210265
shot36693740013142101162196
mitomycin38993740013192115150209301349399422482
C,4415374001316484
transurethral4533374001313568120180221280312366401461494546569
bladder2976389001316184132192251304336
resection.3336389001313284124177226263285342401420
………297641800147120240360
ÚVOD29784600018197183286388
Nádor29764940013170119179237269
močového32734940013190149198254302354412470
měchýře37724940013190143192250296329380
je4181494001312376
nejčastějším42864940013159112134182231271305356378417438527
nádo‑48424940013159108167225260
rem2976509001313284173
močového31755090013190148197253301353411469
traktu3670509001313466116161198256
a39515090013150
v40275090013149
roce4102509001313289138189
202143175090013153105155202
byl45445090013161108131
8.4701509001315473
nejčas‑47995090013159112134183232272303
tějším2976524001313485107145167256
zhoubným32545240013144103161219278337383473
nádorem37495240013159108167225257309398
v41695240013149
ČR.42405240013163117138
V44005240013156
roce4478524001313289138189
202146895240013154105155202
bylo49135240013160108131189
v29765390013150
ČR30485390013162116
nově31865390013159117165217
diagnostikováno3425539001316081130189247305345380402447504552602660718
celkem41655390013149100122167219308
244955390013153
29445625390013154105160
případů,4744539001316092114174224283340358
tedy2976554001313485145194
21,831975540013154101112168
na33925540013159108
10035275540013154101156
00036965540013154109164
osob.3887554001315999157217235
Výrazně41495540013156106138188233292345
převažuje4521554001316192144192242287345367419
vý‑49685540013149101134
skyt2976569001314185137173
u31695690013158
mužů,32475690013190147190248265
poměr35325690013160119208261291
zastoupení3843569001314495134168224281340394451473
mužů43355690013190147190248
a46025690013150
žen4672569001314495152
v48445690013150
roce4914569001313288137188
202129765840013154105155202
byl32025840013161108131
3,03357584001315471124
:35055840013119
1.3548584001315466
Karcinom36385840013155106138184206264322411
močového40735840013190149198254302354412470
měchýře45675840013190143193250296329380
byl49715840013161108131
10.29765990013155103122
nejčastější31315990013160114137186237278314366388428450
příčinou3615599001316194117166189248307367
úmrtí40155990013160150183221244
na42925990013160110
nádorové44355990013160110171231264322371424
one‑48935990013159119174209
mocnění29766140013189147196253305362383
v33796140013149
roce3448614001313288136187
2021.36546140013153104153200212
V38856140013156
roce3960614001313388137187
202141676140013153104153199
zemřelo4386614001314495183213264286343
na47496140013158106
karci‑4875614001314696127173194227
nom29766290013158116205
močového32006290013190147196251298349407464
měchýře36846290013189141190247292324375
86740786290013154107156
osob,4253629001315898155214231
tj.450462900131335573
8,34597629001315371124
úmrtí47416290013158146176213234
na49956290013159107
10029766440013154101156
00031466440013153108163
osob.3333644001315999157217235
743592644001315499
%37156440013181
pacientů38216440013160110159181233291323380
nově42256440013159118166218
diagnostikova‑4467644001315981130189247305345380402447504552602635
ných29766590013159104151208
v32046590013149
letech3273659001312476108159208265
2017–202135586590013153104151195243289340389436
bylo40146590013160107130187
zachyceno4221659001314494142200245292342400457
v46986590013150
časném4768659001314897137193246334
stadiu2976674001314176125185206263
(klinické326267400131297599121178200248293345
stadium3629674001314176126185207264353
I40046740013123
a40496740013150
II),41226740013123457288
tedy4232674001313485146194
neinvazivní44486740013159112134192239289333356405464486
typ4956674001313485146
nádoru29766890013159108167225257316
močového33236890013191149198254302354412470
měchýře.38256890013190143193250296329380397
V42546890013156
rámci4342689001313382171220242
ČR46166890013162116
má47646890013190139
nej‑49356890013159112134167
nižší2976704001315981124167188
hrubou3192704001315990148208267325
incidenci3545704001312380129151210263321369391
Jihomoravský3964704001313860117176265324356406453494539590
kraj,4582704001314780130152170
naopak47807040013159108166226276322
nejvyšší29767190013159112134183235276315337
hrubá3340719001315990148208258
incidence3625719001312381130151210263321370421
byla40737190013161108131180
patrná42807190013161111143175234283
u45907190013159
mužů46767190013190147191249
pro4953719001316092149
Liberecký2976734001314972131185216268317363414
kraj,3414734001314780130152171
u36097340013158
žen3691734001314596154
pro3869734001316193149
Karlovarský40427340013155106137160218267316348389434485
kraj4551734001314780130152
(1).472773400131307797112
7031267490013153101
%32447490013180
všech3341749001314988138186241
karcinomů3599749001314695125169189245301388442
močového40597490013189145192245292341397453
měchýře45297490013189140187243287318367
tvoří4913749001313484139168189
neinfiltrující29767640013159111132188213239260292323380401421468489
karcinomy,3490764001314696126172192249306395440452
dle3966764001316081133
TNM41247640013151121204
klasifikace4353764001314770117156176201228272321369419
jsou4796764001312462119176
to:4997764001313489105