Ces Urol 2023, 27(4):236-242 | DOI: 10.48095/cccu2023030

Holmium laser enucleation of the prostate (HoLEP)

Pavel Tolinger, Aleš Petřík
Urologické oddělení, Nemocnice České Budějovice, a. s.

Tolinger P., Petřík A. Holmium laser enucleation of prostate (HoLEP). For nearly a century, methods limited by the size of the prostate have been established as the gold standard of surgery for benign prostatic hyperplasia (BPH). For glands over 80g open prostatectomy (OP) and for smaller ones transurethral prostatectomy (TURP). Despite their indisputable effect, they bring a high rate of morbidity. The technological development of the 90s of the 20th century enabled new surgical procedures of which Holmium laser enucleation of the prostate (HoLEP) is established as a size-independent method. We try to provide an overview of the development of the method, alternative procedures and new technological possibilities. At the same time we bring a comparison of various parameters with standard procedures up to now. More and more literary sources consider HoLEP to be an effective, safe and long-term effective method of surgical treatment of BPH. Based on this, it is gradually replacing TURP and OP as the new method of choice in the guidelines. HoLEP should be considered as the number one option when planning prostate surgery regardless of prostate size. It can also be offered to patients with a higher risk of bleeding, after a biopsy or after previous procedures on the prostate. The development of technologies promises further speed-up and better safety profile of the procedure which is becoming the new gold standard in BHP surgery.

Keywords: HoLEP, lower urinary tract symptoms, benign prostatic hyperplasia, TURP, open prostatectomy.

Received: September 18, 2023; Revised: October 9, 2023; Accepted: October 13, 2023; Prepublished online: October 13, 2023; Published: December 19, 2023 


References

  1. Das AK, Teplitsky S, Humphreys MR. Holmium laser enucleation of the prostate (HoLEP): a review and update. Can J Urol. 2019; 26(4 Suppl. 1): 13-9.
  2. Shvero A, Kloniecke E, Capella C, et al. HoLEP techniques - lessons learned. Can J Urol. 2021; 28(S2): 11-6. Go to original source...
  3. Fraundorfer MR, Gilling PJ. Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol. 1998; 33(1): 69-72. Go to original source... Go to PubMed...
  4. Scoffone CM, Cracco CM. The en-bloc no-touch holmium laser enucleation of the prostate (HoLEP) technique. World J Urol. 2016; 34(8): 1175-81. Go to original source... Go to PubMed...
  5. Shvero A, Calio B, Humphreys MR, et al. HoLEP: the new gold standard for surgical treatment of benign prostatic hyperplasia. Can J Urol. 2021; 28(S2): 6-10.
  6. Gilling PJ, Kennett K, Das AK, et al. Holmium laser enucleation of the prostate (HoLEP) combined with transurethral tissue morcellation: an update on the early clinical experience. J Endourol. 1998; 12(5): 457-459. Go to original source... Go to PubMed...
  7. Franz J Suarez-Ibarrola R, Pütz P, et al. Morcellation after endoscopic enucleation of the prostate: efficiency and safety of currently available devices. Eur Urol Focus. 2021;21:S2405-4569.
  8. Yilmaz S, Kaya E, Gazel E, et al. HoLEP after prostate biopsy: does it have any impact? World J Urol. 2021; 39(7): 2605-11. Go to original source... Go to PubMed...
  9. Elmansy HM, Kotb A, Elhilali MM. Holmium laser enucleation of the prostate: long-term durability of clinical outcomes and complication rates during 10 years of follow up. J Urol. 2011; 186(5): 1972-1976. Go to original source... Go to PubMed...
  10. Rucker F, Lehrich K, Bohme A, et al. A call for HoLEP: en-bloc vs. two-lobe vs. three-lobe. World J Urol. 2021; 39(7): 2337-45. Go to original source... Go to PubMed...
  11. Chen J, Dong W, Gao X, et al. A systematic review and meta-analysis of efficacy and safety comparing holmium laser enucleation of the prostate with transurethral resection of the prostate for patients with prostate volume less than 100 mL or 100 g. Transl Androl Urol. 2022; 11(4): 407-20. Go to original source... Go to PubMed...
  12. Large T, Krambeck AE. Evidence-based outcomes of holmium laser enucleation of the prostate. Curr Opin Urol. 2018; 28(3): 301-8. Go to original source... Go to PubMed...
  13. Nevo A, Faraj KS, Cheney SM, et al. Holmium laser enucleation of the prostate using Moses 2.0 vs. non-Moses: a randomised controlled trial. BJU Int. 2021; 127(5): 553-9. Go to original source... Go to PubMed...
  14. Bozzini G, Maltagliati M, Besana U, et al. Holmium laser enucleation of the prostate with Virtual Basket mode: faster and better control on bleeding. BMC Urol. 2021; 21(1): 28. Go to original source... Go to PubMed...
  15. Hartung FO, Kowalewski KF, von Hardenberg J, et al. Holmium Versus Thulium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur Urol Focus. 2021 Apr 8. Go to original source... Go to PubMed...
  16. Hartung FO, Kowalewski KF, von Hardenberg J, et al. Holmium Versus Thulium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur Urol Focus. 2022; 8(2): 545-54. Go to original source... Go to PubMed...
  17. Petov V, Babaevskaya D, Taratkin M, et al. Thulium Fiber Laser Enucleation of the Prostate: Prospective Study of Mid- and Long-Term Outcomes in 1328 Patients. J Endourol. 2022; 36(9): 123-6. Go to original source... Go to PubMed...
  18. Lee MS, Assmus M, Cooley LF, et al. Ex Vivo Comparison of Efficiency, Safety, and Surgeon Satisfaction in Four Commercial Morcellators. J Endourol. 2022; 36(4): 514-21. Go to original source... Go to PubMed...
  19. Liu K, Xiao C, Hao Y, et al. "Seven-step two-lobe" HoLEP: a modification to gain efficiency of the enucleation applying relatively low-power holmium laser devices. World J Urol. 2021; 39(7): 2627-33. Go to original source... Go to PubMed...
  20. Assmus MA, Ganesh MB, Lee MS, et al. Contemporary Outcomes for Patients Undergoing Concurrent Surgeries at the Time of Holmium Laser Enucleation of the Prostate Before and After Moses 2.0 BPH Mode. J Endourol. 2021; 35(S3): S8-S13. Go to original source... Go to PubMed...
  21. Enikeev D, Misrai V, Rijo E, et al. EAU, AUA and NICE Guidelines on Surgical and Minimally Invasive Treatment of Benign Prostate Hyperplasia: A Critical Appraisal of the Guidelines Using the AGREE-II Tool. Urol Int. 2022; 106(1): 1-10. Go to original source... Go to PubMed...





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