Ces Urol 2016, 20(4):275-284 | DOI: 10.48095/cccu2016040

Dysfunctions of lower urinary tract in diabetic patients

Jan Mokriš1, Roman Zachoval1,2, Miroslav Záleský1, Vladimír Borovička1, Jiří Stejskal1
1 Urologické oddělení, Thomayerova nemocnice, Praha
2 Urologická klinika, 1. a 3. lékařská fakulta, Univerzita Karlova v Praze

Mokriš J, Zachoval R, Záleský M, Borovička V, Stejskal J. Dysfunctions of lower urinary tract in diabetic patients. Major statement: This review article summarizes recent scientific knowledges about dysfunctions of lower urinary tract in diabetic patients. The article includes pathophysiological processes, clinical and urodynamic findings and treatment of patients with these diagnoses. Diabetes mellitus is a chronic metabolic disease whose incidence is increasing worldwide, and that is associated with high morbidity and mortality. A lot of complications appear due to this disease, especially diabetic nefropathy, neuropathy and retinopathy. Among the complications associated with this disease include dysfunction of lower urinary tract , which are presented in 80% of diabetic patients. Clinical manifestations are diverse - from hyperactive urinary bladder to acontractile detrusor. This review article summarizes recent scientific knowledges about dysfunctions of lower urinary tract in diabetic patients. The article includes pathophysiological processes, clinical and urodynamic findings and also treatment of patients with these diagnoses.

Keywords: Cystopatie, diabetes mellitus, inkontinence, neurogenní močový měchýř.

Received: July 17, 2016; Accepted: November 17, 2016; Published: December 21, 2016 


References

  1. Chudobová M. Demografická situace v České republice v roce 2013, Ústav zdravotnických informací a statistiky České republiky, 2014; číslo: 02/14. Dostupné na: http://www.uzis.cz/rychle-informace/demografickasituace-ceske-republice-roce-2013. Poslední přístup: 4. 11. 2016.
  2. Centers for Disease Control and Prevention. National diabetes statistics report: estimates of diabetes and its burden in the United States, Atlanta, 2014, GA: U.S. Department of Health and Human Services; Dostupné na: https://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf. Poslední přístup: 4. 11. 2016.
  3. Xu Y, Wang L, He J, et al. 2010 China noncommunicable disease surveillance group. Prevalence and control of diabetes in Chinese adults, JAMA. 2013; 310: 948-959. Go to original source... Go to PubMed...
  4. Daneshgari F, Moore C. Diabetic uropathy. Semin Nephrol. 2006; 26: 182. Go to original source... Go to PubMed...
  5. Zachoval R, Záleský M, Heráček J, et al. Neurogenní dysfunkce dolních močových cest. Neurol. praxi; 2004(4): 227.
  6. Frimodt-Moller C. Diabetic cystopathy: epidemiology and related disorders. Ann Intern Med 1980; 92: 318. Go to original source... Go to PubMed...
  7. Yoshimura N, Chancellor M, Andersson K, Christ G. Recent advances in understanding the biology of diabetes associated bladder complications and novel therapy. BJU int 2005; 95: 733. Go to original source... Go to PubMed...
  8. Yamaguchi C, Sakakibara R, Uchiyama T, et al. Overactive bladder in diabetes: a peripheral or central mechanism? Neurourol Urodyn. 2007; 26: 807. Go to original source... Go to PubMed...
  9. Hill S, Fayyad A, Jones G. Diabetes mellitus and female lower urinary tract symptoms, a review. Neurourol Urodyn. 2008; 27: 362. Go to original source... Go to PubMed...
  10. Sasaki K, Chancellor M, Phelan M, et al. Diabetic cystopathy correlates with a long term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root ganglia. J Urol 2002; 168: 1259. Go to original source... Go to PubMed...
  11. Sasaki K, Chancellor MB, Goins WF, et al. Gene therapy using replication - defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Diabetes 2004; 53: 2723. Go to original source... Go to PubMed...
  12. Birnbaum H, Leong S, Kabra A. Lifetime medical costs for women: cardiovascular disease, diabetes and stress urinary incontinence. Women Health Issue 2003; 13: 204-213. Go to original source... Go to PubMed...
  13. Manning J, Korda A, Benness C, Solomon M. The association of obstructive defecation, lower urinary tract dysfunction and the benign joint hypermobility syndrome, a case control study. Int. Urogynecology J Pelvic Floor Dysfunction 2003; 14: 128-132. Go to original source... Go to PubMed...
  14. Moore KN, Saltmarche A, Query B. Urinary incontinence. Non surgical management by family physicians. Can. Fam. Physician 2003; 49: 602-610.
  15. Pinna CH, Zanardo R, Puglisi L. Prostaglandin release impairment in the bladder epithelium of the streptozotocin induced diabetic rats. Eur Pharmacol 2000; 388: 267. Go to original source... Go to PubMed...
  16. Geerlings SE, Meiland R, van Lith EC, et al. Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells, more in diabetic women than in control subjects. Diabetes Care 2002; 25: 1405. Go to original source... Go to PubMed...
  17. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes associated bladder complications and novel therapy. BJU Int. 2005; 95: 733-738. Go to original source... Go to PubMed...
  18. Longhurst PA, Belis JA. Abnormalities of rat bladder contractility in streptozotocin induced diabetes mellitus. J Pharmacol Exp Ther. 1986; 238: 773-777.
  19. Luheshi GN, Zar MA.The effect of streptozotocin induced diabetes on cholinergic motor transmission in the rat urinary bladder. Br J Pharmacol. 1991; 103: 1657-1662. Go to original source... Go to PubMed...
  20. Waring JV, Wendt IR. Effects of streptozotocin induced diabetes mellitus on intracellular calcium and contraction of longitudinal smooth muscle from rat urinary bladder. J Urol. 2000; 163: 323-330. Go to original source...
  21. Liu G, Daneshgari F. Temporal diabetes and diuresis remodeling of the urinary bladder in the rat. Am J Physiol Regul INtegr Comp Physiol 2006; 291: R837. Go to original source... Go to PubMed...
  22. Longhurst PA, Wein AJ, Levin RM. In vivo urinary bladder function in rats following prolonged diabetic and non diabetic diuresis. Neurourol Urodyn 1990; 9: 171. Go to original source...
  23. Satriano J. Kidney growth, hypertrophy and the unifying mechanism of diabetic complications. Amino Acids 2007; 33: 331. Go to original source... Go to PubMed...
  24. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes associated bladder complications and novel therapy. BJU Int 2005; 95: 733. Go to original source... Go to PubMed...
  25. Beshay E, Carrier S. Oxidative stress plays role in diabetes induced bladder dysfunction in a rat model. Urology 2004; 64: 1062-1067. Go to original source... Go to PubMed...
  26. Kanika ND, Chang J, Tong Y, et al. Oxidative stress status accompanying diabetic bladder cystopathy results in the activation of protein degradation pathways. BJU Int 2011; 107: 1676-1684. Go to original source... Go to PubMed...
  27. Changolkar AK, Hypolite JA, Disanto M, et al. Diabetes induced decrease in detrusor smooth muscle force is associated with oxidative stress and overactivity of aldose reductase. J Urol. 2005, 173: 309-313. Go to original source... Go to PubMed...
  28. Tong YC, Cheng JT, Wan WC. Effects of Ba-Wei-Die-Huang-Wan on the cholinergic function and protein expression of M2 muscarinic receptor of the urinary bladder in diabetic rats. Neurosci Lett. 2002, 13; 330(1): 21-24. Go to original source... Go to PubMed...
  29. Sun Y, Chai T. Role of purinergic signaling in voiding dysfunction. Curr Bladder Dysfunction Rep. 2010; 5: 219. Go to original source... Go to PubMed...
  30. Poladia DP, Bauer JA. Early cell specific changes in nitric oxide synthases, reactive nitrogen species formation, and ubiquitination during diabetes related bladder remodeling. Diabetes Metab Res Rev. 2003; 19: 313. Go to original source... Go to PubMed...
  31. Christ GJ1, Bushman W, Fraser MO. Impact of diabetes and obesity on the prostate and urethra: Implications to improve bladder dysfunction understanding and treatment. J. Urol. 2009; 182: S38-44. Go to original source... Go to PubMed...
  32. Liu G, Lin YH, Yamada Y, Daneshgari F. External urethral sphincter activity in diabetic rats. Neurourol Urodyn. 2008; 27: 429-434. Go to original source... Go to PubMed...
  33. Yang Z, Dolber PC, Fraser MO. Diabetic urethropathy compounds the effects of diabetic cystopathy. J Urol. 2007; 178: 2213-2219. Go to original source... Go to PubMed...
  34. Changxiao H, Zhengyong Y, Shibing Y. Clinical and urodynamic evaluation of women referred with diabetes mellitus. Int. Urogynecol. J. 2014; 25: 979-983. Go to original source... Go to PubMed...
  35. Zderic SA, Chacko S, DiSanto M, Wein AJ. Voiding function: relevant anatomy, physiology, pharmacology, and molecular aspects. In: Adult and Pediatric Urology, 4th ed. Edited by J Gillenwater, J Grayhack, S Howards et al. Philadelphia: Lippincott 2002; 1061-1114.
  36. Kaplan SA, Te AE and Blaivas JG. Urodynamic findings in patients with diabetic cystopathy. J Urol 1995; 153: 342. Go to original source... Go to PubMed...
  37. Lee WC, Wu HP, Tai TY, Liu SP, Chen J, Yu HJ. Effects of diabetes on female voiding behavior, J Urol. 2004; 172: 989-992. Go to original source... Go to PubMed...
  38. Nakayama H, Jørgensen HS, Pedersen PM, Raaschou HO, Olsen TS. Prevalence and risk factors of incontinence after stroke. The Copenhagen Stroke Study. Stroke. 1997; 28: 58. Go to original source... Go to PubMed...
  39. Lifford KL, Curhan GC, Hu FB, Barbieri RL, Grodstein F. Type 2 diabetes mellitus and risk of developing urinary incontinence. J Am Geriatr. Soc. 2005; 53: 1851. Go to original source... Go to PubMed...
  40. Brown JS, Vittinghoff E, Lin F, Nyberg LM, Kusek JW, Kanaya AM. Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey 2001-2002. Diabetes Care 2006; 29: 1307. Go to original source... Go to PubMed...
  41. James R, Hijaz A. Lower urinary tract symptoms in women with diabetes mellitus: A Current Review, Curr Urol Rep, 2014; 15: 440. Go to original source... Go to PubMed...
  42. Daneshgari F, Liu G, Imrey PB. Time dependent changes in diabetic cystopathy in rats include compensated and decompensated bladder function. J Urol. 2006; 176: 380-386. Go to original source... Go to PubMed...
  43. Ho CH, Tai HC, Yu HJ. Urodynamic findings in female diabetic patients with and without overactive bladder symptoms. Neurol Urodyn. 2010; 29: 424. Go to original source... Go to PubMed...
  44. Mumtaz FH, Sullivan ME, Thompson CS, et al. Alterations in the nitric oxide synthase binding sites and non-adrenergic, non-cholinergic mediated smooth muscle relaxation in the diabetic rabbit bladder outlet: possible relevance to the pathogenesis of diabetic cystopathy. J Urol. 1999; 162: 558. Go to original source...
  45. Kitami K. Vesicourethral dysfunction of diabetic patients. Nippon Hinyokika Gakkai Zasshi. 1991; 82: 1074. Go to original source... Go to PubMed...
  46. Changxiao H, Zhengyong Y, Shibing Y, et al. Clinical and urodynamic evaluation of women referred with diabetes mellitus. Int Urogynecol J. 2014. Go to original source...
  47. Krhut J et al. Neurourologie. Galén 2005; 87: 95.
  48. Hanuš T, et al. Ureterocystoplastika - ureterální augmentace močového měchýře. Rozhledy v chirurgii. 1998; 77(11): 483-486.
  49. Daniels DH, Powell CR, Braasch MR, Kreder KJ. Sacral neuromodulation in diabetic patients: success and complications in the treatment of voiding dysfunction. Neurourol Urodyn. 2010; 29: 578. Go to original source... Go to PubMed...





Web časopisu Česká urologie je určen pouze pro lékaře a odborníky
z oblasti medicíny nebo farmacie.



Beru na vědomí, že informace zveřejněné na těchto stránkách
nejsou určeny pro laickou veřejnost.



Odejít Vstoupit