Czech urology, 2025 (vol. 29), issue 3

Editorial

Marcel Drlík

Ces Urol 2025, 29(3):129-130  

Modeling human kidney in vitro – the potential of renal organoids and tubuloids for urology

Viktória Filipková, Tomáš Pelikán, Roman Zachoval, Petr Heneberg

Ces Urol 2025, 29(3):131-140 | DOI: 10.48095/cccu2025019  

Major statement: This review presents a comprehensive survey of renal organoids, encompassing their characterization, potential applications, limitations, and prospects, with particular emphasis on their relevance to the field of urology.Summary: Renal organoids are advanced tissue cultures that resemble key structural, functional, and developmental aspects of native kidney tissue in vitro. Organoids enable a person- alized approach to disease diagnosis and treatment, with their relevance in urology continuously increasing. Organoids derived from induced pluripotent stem cells allow modeling of embryonic nephron development,...

Penile rehabilitation after radical prostatectomy

Marek Broul, Aneta Hujová

Ces Urol 2025, 29(3):141-145 | DOI: 10.48095/cccu2025020  

Penile rehabilitation after radical prostatectomy is a multimodal approach aimed at supporting the recovery of erectile function through a combination of pharmacotherapy, mechanical devices, and other interventional methods. Available clinical studies suggest that early, structured protocols may help a subset of patients preserve or regain erectile function; however, the quality of evidence is uneven and findings are heterogeneous. The most commonly used modalities include phosphodiesterase type 5 inhibitors and vacuum erection devices. Other approaches - such as low-intensity extracorporeal shock wave therapy or penile vibratory stimulation - have...

Incidental finding of prostate cancer during surgery for benign prostatic hyperplasia – how to proceed?

Peter Polaček, Otakar Čapoun, Martin Malý, Filip Vlček, Alžběta Kantorová, Viktor Soukup

Ces Urol 2025, 29(3):146-151 | DOI: 10.48095/cccu2025021  

The so-called incidental prostate cancer, identified during surgical treatment for benign prostatic hyperplasia, particularly transurethral resection of the prostate, represents a specific clinical scenario with no clearly defined standard of care. This review summarizes current data on the incidence, predictive factors, and options for further diagnosis and treatment of incidental prostate cancer. Special attention is given to the role of postoperative prostate specific antigen levels, multiparametric magnetic resonance imaging, the value of subsequent biopsy, and the prediction of residual cancer presence or absence. The roles of radical prostatectomy...

Positive surgical margins in renal malignancies after nephron-sparing surgery – results of a single-centre retrospective analysis

Rostyslav Luzan, Petr Klézl, Jindřích Šonský, Jakub Hanych, Robert Grill

Ces Urol 2025, 29(3):152-157 | DOI: 10.48095/cccu2025016  

Objective: The aim of this study was to compare the incidence of positive surgical margins (PSM) in nephron-sparing surgeries on the kidneys, postoperative follow-up, and complications in patients at our institution with global trends. Material and methods: The analysis was conducted on a set of procedures performed at the Urology clinic of University Hospital Královské Vinohrady from 2011 to 2021. Results: During the analyzed period, a total of 611 nephron-sparing surgeries were performed at our clinic. Of these, 117 patients underwent laparoscopic partial nephrectomy (LPN) and 494 patients underwent open partial nephrectomy...

Evaluation of oncological outcomes using prognostic models in patients operated on for renal cancer Ş experience from a single center

Marek Kašík, Michal Fedorko

Ces Urol 2025, 29(3):158-163 | DOI: 10.48095/cccu2025017  

Major statement: This paper aims to evaluate the outcomes of patients who underwent surgical treatment of renal cell carcinoma at the Department of Urology of the University Hospital Brno between 2014 and 2022 using the prognostic models.Summary: Objectives of the study: The aim of this study was to evaluate the cohort of patients with surgical treatment of renal cell carcinoma at our institution with regard to prognostic factors using the Leibovich and GRANT prognostic models.Patients and methods: A retrospective evaluation was performed of baseline data of patients who underwent radical or partial nephrectomy...

Histological findings in a completely duplicated kidney and ureter after heminephrectomy

Martina Košudová, Minh Nguyet Tranová, Pavel Navrátil, Miroslav Podhola, Ivo Novák

Ces Urol 2025, 29(3):164-169 | DOI: 10.48095/cccu2025018  

Introduction: Complete duplication of the kidney and ureter is a common congenital anomaly of the urinary tract, often associated with ectopic ureter, ureterocele, or vesicoureteral reflux. In cases of severe hypofunction of the upper moiety, heminephrectomy is indicated. Objective: The aim of this study was to analyze the histopathological findings in resected upper segments of completely duplicated kidneys in pediatric patients undergoing heminephrectomy. Methods: A retrospective analysis was conducted on 26 children operated on between 2000 and 2024 for complete duplication of the upper urinary tract at the University...

Comprehensive news in oncourology – KNOU 2025

Tereza Zdobinská

Ces Urol 2025, 29(3):171-172  

Czech Urology Boot Camp 2025

Kateřina Dušková, Michaela Dvořáková

Ces Urol 2025, 29(3):173-174