Ces Urol 2004, 8(1):21-23 | DOI: 10.48095/cccu2004006

Has significance spontaneous familial screening of prostate cancer?

J. Marenčák, S. Náter, M. Maskalik

Urologické oddelenie NsP Skalica

Introduction and purpose: Hereditary forms account for approximately 10 % of all prostate cancer (PC). The aim of this study was: to evaluate significance of positive familial history as risk factor of PC and efficiency of PC familial screening.

Material and methods: From January 1999 to December 2001 was detected 68 men (average age 65,8 years, range 52 - 81 years) with histologically proved PC. A occurence of PC was ascertained in a families retrospectivelly and prospectivelly. 207 "healthy" relatives men (aged 40 - 75 years) was examined (digital rectal examination, serum level of PSA, eventually prostate biopsy) prospectivelly. So - called familial PC is a detection at least two men with histological proved PC in a one family. Severe criteria of hereditary PC are showed in a table 2. Genetic analysis wasn´t made.
From January 1996 to December 1998 was sreened 196 men (not relatives, average age 61,5 years, range 51 - 74 years), who were admitted in hospital for non urological diseases. A incidence of PC in this group of men was statistically compared to a occurrence of PC in a familial screening.

Results: Familial PC was demonstrated by 12/ 8 (17,7 %) families and hereditary PC was screened by 2/68 (2,9 %) families. PC was detected significantly higher (p< 0, 01) in a family screening (4/207; 1,9 %) then by men without family relationship (2/196; 1 %). Metastatic PC wasn´t detected in a family screening at the time of diagnosis PC.

Conclusions: A screening of PG is still controversial. There are needed a genetic analysis of families with high risk of PC.

Keywords: prostate cancer (PC), family history, screening of relatives, hereditary prostate cancer

Published: January 1, 2004