Ces Urol 1999, 3(1):40-42

Small cell carcinoma of urinary bladder

R. Zachoval¹, P. Palascak², M. Urban¹, A. Khamlu³, A. Monnier⁴, D. Debieuvre⁵

¹ Urologická klinika Fakultní nemocnice Královské Vinohrady, Praha

² Urologické odděleni nemocnice Paul Morel, Vesoul, Francie

³ Centrum patologie, Besancon, Francie

⁴ Onkologické oddělení nemocnice A. Boulloche, Montbeliard, Francie

⁵ Plicní oddělení nemocnice Paul Morel, Vesoul, Francie

Primary small cell carcinoma of the bladder is a rare condition with an incidence of 0,5-1 % and like small cell carcinoma of the lung is a highly malignant desease. All 133 cases reported to date were locally advanced at diagnosis and in 1/3 of cases represented a generalized disease. Regardless of intensive treatment, the majority of patients will die early after the diagnostic biopsy. Survival rate is about 7 months.
Our presentation adds a new case report of a primary small cell bladder carcinoma with muscle invasion for which we indicated radical cystectomy. For serious internal diseases the proposed radical cystectomy was not recommended. The patient underwent TUR followed by adjuvant chemotherapy and radiotherapy. Ten months after the diagnosis, the patient shows no tumor reccurence.
The optimal standard treatment of the primary small cell carcinoma of the bladder has yet to be established. While some authors prefer chemotherapy and radiotherapy, others prefer surgical management based on radical cystectomy or TUR plus neoadju-vant or adjuvant therapy.

Keywords: Small cell carcinoma, Bladder cancer

Published: January 1, 1999