Ces Urol 2009, 13(3):199-206 | DOI: 10.48095/cccu2009013
Botulinum toxin: current use in urology
- Krajská nemocnice Liberec, a.s., Urologické oddělení
Botulinum toxin is a presynaptic neuromuscular blocking agent, which induce reversible muscle weakness. From feared poison he changed to intensive researched drug. Many medical disciplines have discovered the indication for treatment. In urology the first experiences is from 1988, when botulinum toxin was used to treat detrusor-sphincter dyssynergia. Nowadays is mostly used to treat neurogenic detrusor overactivity. Effect of treatment can last 6-9 month and continence is restored in about 90% of the patients. Based on actual knowledges is possible to repeat treatment. Influece on decrease of prostatae volume and painful bladder syndrom is still in phase of clinical trials.
Keywords: botulinum toxin, detrusor overactivity, detrusor sphincter dyssynergia, urinary retention, benign prostatic enlargement
Received: February 17, 2009; Accepted: March 10, 2009; Published: June 1, 2009
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