Ces Urol 2010, 14(2):99-103 | DOI: 10.48095/cccu2010016

Urine survivin in noninvasive diagnosis of transitional cell carcinoma of the urinary bladder

Michael Pešl¹, Marko Babjuk¹, Viktor Soukup¹, Monika Szakácsová¹, Pavel Dundr², Tomáš Hanuš¹

¹ Urologická klinika 1. LF UK a VFN, Praha

² Ústav patologie 1. LF UK a VFN, Praha

Aim:
To assess performance of survivin level in urine for noninvasive detection of urinary bladder cancer.

Materials and methods:
There were 151 patients enrolled in this study (84 patients with urinary bladder tumoru and 67 screenings) from July 2004 to January 2006. Patiens were divided into different groups according to tumour stage, grade, multiplicity, size, new cases and recidives.

Results:
The mean survivin level in patients with tumour was 32.4 pg/ml, and 22.4 pg/ml in the screenings (p = 0.001). The mean survivin level of patients depending tumour stage, grade and size was significant. Cut-off of urine survivin level was estimated at 33.9 pg/ml with specificity 90%, sensitivity 45%, positive and negative predictive value 45%, 86% and 53% respectively. Sensitivity was highest in the group of patients with high grade tumours (68-100%), in large tumours (80%) and in tumours larger than 5 cm (79%).

Conclusions:
Our results demonstrate that high level of survivin in urine corelates with the tumour stage and size as well as with the tumour grade. Survivin level in urine can be used as predictor of high stage and low diferenciation of bladder tumour.

Keywords: urinary bladder, survivin, urotelial carcinoma

Received: October 26, 2009; Accepted: January 28, 2010; Published: March 1, 2010