Czech urology, 2009 (vol. 13), issue 2

Vážené kolegyně a kolegové,

Miroslav Hanuš

Ces Urol 2009, 13(2):139  

Development and clinical evaluation of new drugs

David Suchý, Milan Hora, Jindřich Fínek

Ces Urol 2009, 13(2):141-148 | DOI: 10.48095/cccu2009003  

The discovery and development of a drug is a process of many steps. The purpose of drug discovery is to identify chemicals that have a great chance of providing therapeutic benefit. Experiments designed to discover pharmacologic effect in patients have their fundamentals in the experimental data obtained from animals. Clinical experiments in humans classically are divided into at least three phases. Phase I presents first in man administration of study drugs. Phase II shows the response to treatment in patients with target disease state. The keystone to any drug development program and the gold standard of experimentation with drugs in humans is the...

Interdisciplinary communication between urologist and oncologist and its implementation in hormone refractory prostate cancer

Marko Babjuk, Petr Brabec, Ladislav Dušek, Tomáš Pavlík, Jindřich Fínek, Dalibor Pacík, Luboš Petruželka, Michaela Matoušková

Ces Urol 2009, 13(2):149-160 | DOI: 10.48095/cccu2009004  

Professional communication among physicians is currently of growing importance, namely in fields that stand in the centre of interest of two or more medical disciplines. It holds also for cancer diagnoses that are associated with urogenital system. Using advanced stages of prostate cancer as example, we introduce here technological and operational background of newly initiated project UJO (?Urology Joins Oncology?). The project strives to facilitate collaboration between urologists and oncologists using modern ICTs. Non-interventional clinical registry is based on fully parametric database equipped by functional on-line system, centralized data management...

Prognostic value of p53, Ki-67 expression in the urothelial carcinoma tissue and urinary bladder non-tumor mucosa

Viktor Soukup, Marko Babjuk, Jaroslava Dušková, Michael Pešl, Monika Szakácsová, Libor Zámečník, Jan Dvořáček, Ctibor Povýšil

Ces Urol 2009, 13(2):161-167 | DOI: 10.48095/cccu2009005  

Aim: The aim of the prospective study was to assess the prognostic value of p53, Ki-67 expression level in the urothelial carcinoma tissue and in the samples of urinary bladder non-tumor mucosa.Material and methods: Forty eight patients with first history of Ta, T1 urinary bladder carcinoma were enrolled into the study. They were all followed for 31,3 month at average. Primary antibodies (Imunotech/ DAKO) were used to detect p53 and Ki-67 positivity. The expression was evaluated semi quantitatively and expressed as HSCORE, where HSCORE = .pi (i + 1), in which I is one of the four positivity grades, Pi stands for the positive nuclei...

Our early experience with robotic-assisted laparoscopic radical prostatectomy - first 153 cases

Jan Doležel, Jaroslav Tvarůžek, Michal Staník, Radek Zachoval, Igor Šimoník, Milan Korsa, Václav Vagunda

Ces Urol 2009, 13(2):168-177 | DOI: 10.48095/cccu2009006  

Aim: We present our early experience with the robot-assisted laparoscopic radical prostatectomy (RALP) in one of the four centres of robotic surgery in the Czech Republic.Material and methods: In the period from 1. 5. 2007 till 30. 9. 2008 we performed 153 RALP using 3 armed Da Vinci system (Intuitive surgical) in the centre of robotic surgery Vysočina. The operation was indicated mainly in patients with the clinically localized prostate cancer, stage cT1c was identified in 78.1%, in 20% cT2 and we operated only two patients (1.5%) with locally advanced disease. The mean prostate-specifi c antigen (PSA) value was 7.2 ng/ml (2-19 ng/ml)....

Atypical torsion of the testicular appendix

Oldřich Šmakal, Igor Hartmann, Jan Vrána, Michal Grepl, Kamila Michálková

Ces Urol 2009, 13(2):178-181 | DOI: 10.48095/cccu2009007  

Authors present a case of testicular appendix torsion that imitated a tumor of paratesticular tissues by its calm clinical course and extent of affected appendix without inflammation signs.

Zemřel profesor Hvězdoslav Stefan

Ces Urol 2009, 13(2):182-186  

Zpráva z workshopu "Moderní chirurgická léčba prolapsů pánevního dna"

Ces Urol 2009, 13(2):182-186  

České urologické práce v zahraničních periodicích v roce 2008

Ces Urol 2009, 13(2):182-186