Ces Urol 2010, 14(3):139-147 | DOI: 10.48095/cccu2010026

Genetic risk of prostate cancer

Milan Král1, Vlasta Vyhnánková1, Vladimír Študent1, Jan Bouchal2
1 Urologická klinika LF UP a FN, Olomouc
2 Laboratoř molekulární patologie LF UP, Olomouc

Prostate cancer is a disease which origin is affected appart from enviromental factors also by genetic factors. Despite extensive research, the ethiopathogenesis of prostate cancer is only slightly explored. According to genetic risk we distinguish between sporadic cancers (mostly prevalent), familial and hereditary cancers. From genetic abnormalities mostly seen in prostate cancer we can name genetic changes in gene for androgen receptor, from other candidate genes there is RNAseL on locus HPC1, genes ELAC2, MSR1, BRCA 1 a 2, fusion genes TMPRSS2+ERG/ETV, KLF6 etc. With the development of molecular biologic methods we have more options to understand causations of prostate cancer origin and we can better influence further course of the disease. The aim of this overview is to present current status of genetic risk for prostate cancer development.

Keywords: genetics, prostate cancer, risk

Received: February 23, 2010; Accepted: May 18, 2010; Published: June 1, 2010 


Podpořeno interním grantem LF UP Olomouc č. 91110261.

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