Ces Urol 2015, 19(3):201-209 | DOI: 10.48095/cccu2015030

Urogenital lymphoma

Daniela Kovářová¹, Samuel Vokurka², Olga Dolejšová¹, Milan Hora¹, Jana Kuntscherová³, Boris Kreuzberg⁴, Zdeněk Chudáček⁵

¹ Urologická klinika LF UK a FN Plzeň

² Hematologicko-onkologické oddělení LF UK a FN Plzeň

³ Šiklův ústav patologie LF UK a FN Plzeň

⁴ Klinika zobrazovacích metod LF UK a FN Plzeň

⁵ Radiodiagnostické oddělení LF UK a FN Plzeň

Kovářová D, Vokurka S, Dolejšová O, Hora M, Kuntscherová J, Kreuzberg B, Chudáček Z. Urogenital lymphoma.

Aim: The aim of this report is to describe the issue of lymphomas of urological organs through the analysis of our own patients.

Methods: At the Departement of Urology in Pilsen the diagnosis of malignant lymphoma occured in ten patients in the period 2010 till 2015. We performed a retrospective analysis of the diagnostic process, disease course and outcome. Histology for confirmation of the diagnosis was obtained by surgical operation or targeted biopsy. The patients were thereafter treated by immunochemotherapy R-CHOP (rituximab, cyklophoshamid, vincristine, adriamycin/doxorubicin, prednisone) or R-COP (without doxorubicin).

Results: Most frequent were testicular lymphomas in seven patients, one case of right adrenal lymphoma, one lymphoma of peripelvic tissue of left kidney and one patient with lymphoma of the small pelvis in close contact to the urinary bladder. Six patients with testicular lymphoma and the patient with lymphoma of peripelvic tissue achieved complete remission. In one patient with testicular lymphoma and the patient with lymphoma of the small pelvis the therapy was ongoing and regression of findings were documented at the time of publication. The patient with adrenal lymphoma achieved partial remission.

Conclusion: Primary or secondary urogenital lymphomas are rare urological malignancies. Nevertheless this illness should be contemplated in the differential diagnosis. The role of urologist is to provide surgical treatment and histological verification of the disease, followed by haematooncologal therapy. Early diagnosis and prompt treatment is fundamental for inducing complete remission and for long-term survival of patients with this disease.

Keywords: Malignant lymphoma, urogenital lymphoma, testicular lymphoma, immunochemotherapy.

Received: July 14, 2015; Accepted: September 5, 2015; Prepublished online: September 3, 2015; Published: October 7, 2015